—
— FRUZAQLA® ex-US sales driving growth – now approved or launched in 41 countries —
— Strong progress in ATTCs, a source of novel drug candidates with broad therapeutic potential —
All amounts are expressed in US dollars unless otherwise stated. A glossary of abbreviations is on page 25.
Global sales growth driven by
- In-market sales from key
China commercial products up over 40% compared to the first half of 2025. ELUNATE® (fruquintinib inChina ) up 41% to$60.8 million as it expanded reimbursement coverage for endometrial cancer and was approved for kidney cancer. SULANDA® up 45% to$18.4 million , boosted by upgraded recommendation inChinese Society of Clinical Oncology guidelines for neuroendocrine tumors. - In-market sales of FRUZAQLA® (fruquintinib ex-
China ) ex-US up ~70% to$68.9 million during first half of 2026, alongside steady US sales, driven by the need for novel non-chemo treatment options in mCRC and ongoing positive experiences of oncologists in third line setting. - Profitability maintained amid higher R&D investment, with net income attributable to
HUTCHMED at$15.9 million (H1-25:$455.0m including$416.3m gain on divestment of 45% ofShanghai Hutchison Pharmaceuticals Limited (SHPL)), which allowed the Company to maintain a strong cash balance of$1.37 billion .
Multiple first-in-class Antibody-Targeted Therapy Conjugate (ATTC) candidates in clinical trials
- Initiated clinical trial of HMPL-A251 (PI3K/PIKK-HER2) in
December 2025 and of HMPL-A580 (PI3K/PIKK-EGFR) inMarch 2026 and presented preclinical data atAmerican Association for Cancer Research Annual Meeting. Both ATTCs are progressing through dose escalation as planned. - HMPL-A830 clinical trial application approved in
July 2026 , based on a different ATTC payload platform.
Regulatory and clinical achievements across late-stage clinical portfolio
- New Drug Application (NDA) approval of ELUNATE® with sintilimab for second-line kidney cancer in
China inMay 2026 , supported by FRUSICA-2 Phase III data showing median progression-free survival (PFS) of 22.2 months vs. 6.9 months in control group. - NDA acceptance of sovleplenib for warm autoimmune hemolytic anemia (wAIHA) in
China inApril 2026 , supported by ESLIM-02 Phase III data presented atEuropean Hematology Association Congress with durable response rate of 66.0%, along with NDA acceptance for immune thrombocytopenia (ITP) inChina inFebruary 2026 ; both wAIHA and ITP indications received priority review status. - Positive SACHI Phase III data of ORPATHYS® in combination with TAGRISSO® (osimertinib) sub-group analysis published in
The Lancet inJanuary 2026 with median overall survival (OS) of 22.9 months vs. 7.9 months with chemotherapy. NDA approval for third-line MET-amplified gastric cancer inChina inJune 2026 , supported by Phase II data presented atAmerican Society of Clinical Oncology Annual Meeting with objective response rate of 32.3%. - Positive pivotal Phase II data of fanregratinib (FGFR inhibitor) in intrahepatic cholangiocarcinoma presented at
European Society for Medical Oncology Gastrointestinal Cancers Congress . - Initiated Phase III trial of HMPL-760 (BTK inhibitor) in combination with rituximab and chemotherapy for second-line diffuse large B-cell lymphoma in
March 2026 .
Dr
Mr
Dr
2026 INTERIM RESULTS & BUSINESS UPDATES
I. COMMERCIAL OPERATIONS
There was a strong rebound in
ELUNATE® in-market sales were up 41% to
SULANDA® in-market sales were up 45% to
FRUZAQLA® in-market sales growth was primarily driven by sales outside the US, which had growth of ~70%, contributed by approvals or launches in 41 countries to date, including securing reimbursement in
Total consolidated revenue for oncology products increased 23% to
Other Oncology/Immunology revenue, consisting of upfront, regulatory milestones, R&D services and licensing revenue was
| ($ in millions) | In-market Sales* | Consolidated Revenue** | ||||||||||||
| H1 2026 | H1 2025 | % Change | (CER) | H1 2026 | H1 2025 | % Change (CER) | ||||||||
| FRUZAQLA® | +14 | % | (+14%) | — | — | |||||||||
| ELUNATE® | +41 | % | (+33%) | +40 | % | (+32%) | ||||||||
| SULANDA® | +45 | % | (+37%) | +45 | % | (+37%) | ||||||||
| ORPATHYS® | +3 | % | (-3%) | +48 | % | (+39%) | ||||||||
| TAZVERIK®*** | — | — | — | — | ||||||||||
| Oncology Products | $279.8 | $234.4 | +19 | % | (+17%) | $121.4 | $99.1 | +23 | % | (+18%) | ||||
| Takeda upfront, regulatory milestones and R&D services | -30 | % | (-30%) | |||||||||||
| Other revenue (R&D services and licensing) | +35 | % | (+35%) | |||||||||||
| Total Oncology/?Immunology | $162.3 | $143.5 | +13 | % | (+10%) | |||||||||
| Other Ventures | -14 | % | (-19%) | |||||||||||
| Total Revenue | $278.3 | $277.7 | — | (-4%) | ||||||||||
* FRUZAQLA®, ELUNATE® and ORPATHYS® mainly represent total sales to third parties as provided by Takeda, Eli Lilly and AstraZeneca, respectively.
** FRUZAQLA® represents manufacturing revenue and royalties paid by Takeda to
*** Ipsen is the Marketing Authorization Holder for TAZVERIK®, for which
II. 2026 REGULATORY UPDATES
- Savolitinib sNDA approved by NMPA in 3L MET-amplified GC in
June 2026 . - Savolitinib MAA approved (temporary authorization) by
Swissmedic in combination with TAGRISSO® for 2L EGFRm NSCLC with MET amplification and/or overexpression inFebruary 2026 . - Fruquintinib sNDA approved by NMPA in combination with sintilimab for 2L RCC in
May 2026 . - Sovleplenib NDA accepted by NMPA for 2L wAIHA in
April 2026 . - Sovleplenib NDA resubmission accepted by NMPA for 2L ITP in
February 2026 . - Tazemetostat voluntary withdrawal by Ipsen in
China inMarch 2026 .
III. 2026 LATE-STAGE CLINICAL DEVELOPMENT ACTIVITIES
Savolitinib (ORPATHYS® in
- Expecting topline results in H2 2026 for SAFFRON and SANOVO, following full enrollment in H2 2025:
- SAFFRON global Phase III study for 2L/3L EGFRm NSCLC patients with MET amplification and/or overexpression could support global filings (NCT05261399).
- SANOVO China Phase III study for 1L EGFRm NSCLC patients with MET overexpression could support
China filing (NCT05009836).
- Published sub-group analysis of SACHI China Phase III study for 2L EGFRm NSCLC patients with MET amplification in
The Lancet inJanuary 2026 , showing mOS of 22.9 months vs 7.9 months with chemotherapy (HR 0.32) when excluding control group patients who received subsequent MET inhibitor. - Presented and published positive China Phase II pivotal study data in 3L MET-amplified GC at ASCO 2026 and in Nature Medicine in
June 2026 , respectively, with IRC-assessed ORR of 32.3%, mPFS of 4.0 months and mOS of 6.9 months (NCT04923932).
Sovleplenib (HMPL-523), an investigative and highly selective oral inhibitor of Syk
- Presented positive ESLIM-02 China Phase III study data in 2L wAIHA at EHA 2026
Congress inJune 2026 , having met its primary endpoint of durable response rate of 66.0%, showing median time to response of 3.1 weeks and median cumulative duration of response of 16.1 weeks.
Fanregratinib (HMPL-453), a novel, highly selective and potent inhibitor targeting FGFR 1, 2 and 3
- Presented positive China Phase II pivotal study data in 2L FGFR2 fusion/rearrangement ICC at
ESMO Gastrointestinal Cancers Congress inJuly 2026 , having met its primary endpoint of IRC-assessed ORR of 42.5%, as well as showing mPFS of 6.9 months and mOS of 16.6 months. An NDA for 2L ICC was accepted by NMPA with priority review status inDecember 2025 (NCT04353375).
HMPL-760, a non-covalent, third generation BTK inhibitor, targeting wild-type and C481S-mutated BTK
- Initiated China Phase III study in combination with R-GemOx (rituximab, gemcitabine and oxaliplatin) in patients with 2L relapsed/refractory DLBCL versus placebo in combination with R-GemOx in
March 2026 (NCT07409428). Primary endpoints are investigator-assessed PFS and OS.
IV. ANTIBODY-DRUG CONJUGATES RESEARCH & DEVELOPMENT
HMPL-A251, a first-in-class PI3K/PIKK-HER2 ATTC comprising of a highly selective and potent PI3K/PIKK inhibitor payload linked to a humanized anti-HER2 IgG1 antibody, via a cleavable linker
- Progressing a dose-escalation and expansion trial for unresectable, advanced or metastatic HER2-expressing solid tumors with first patient dosed in
December 2025 (NCT07228247). - Preclinical data showed anti-tumor activity in DXd-resistant cell line and good efficacy and safety when in combination with chemotherapy via a differentiated mechanism of action.
HMPL-A580, a first-in-class PI3K/PIKK-EGFR ATTC comprising of a highly selective and potent PI3K/PIKK inhibitor payload linked to an anti-EGFR IgG1 antibody, via a cleavable linker
- Progressing a dose-escalation and expansion trial for solid tumors, including NSCLC, CRC, HNSCC and ESCC with first patient dosed in
March 2026 (NCT07396584). - Preclinical data presented at AACR 2026 showing tumor shrinkage in osimertinib-resistant EGFRm NSCLC cell line and good efficacy and safety when used in combination with osimertinib in EGFRm PAM non-altered NSCLC cell line.
HMPL-A830
- Plans for global clinical trial initiation in H2 2026. Preclinical data showed superior potency and safety profiles to antibodies or small molecules with the same target, with data to be presented at a scientific conference.
V. COLLABORATION UPDATES
ImageneBio is developing IMG-007, a non-T cell depleting, antibody-dependent cell-mediated cytotoxicity -silenced OX40 antagonist discovered by
- Phase IIb trial (NCT07037901) in patients with moderate-to-severe atopic dermatitis progressing, with an amended protocol and topline data anticipated in the fourth quarter of 2027.
- Phase II trial initiation in patients with alopecia areata expected in 2026, with initial data expected in 2028.
VI. OTHER VENTURES
- Other Ventures consolidated revenue decreased to
$116.0 million for the six months endedJune 30, 2026 (H1-25:$134.2 million ) which has minimal impact on profitability as the segment is predominantly low-margin prescription drug distribution business inChina andHUTCHMED continues to optimize working capital management. - Consolidated net income attributable to
HUTCHMED fromOther Ventures decreased to$3.8 million (H1-25:$24.0m ), primarily due to lower equity earnings from SHPL following our 45.0% equity interest disposal in 2025.
VII. SUSTAINABILITY
The 2025 Sustainability Report was published in
In 2026, our sustainability initiatives have continued to receive strong recognition. Most recently, our commitment was reflected in an upgraded AA rating by MSCI, recognizing
FINANCIAL HIGHLIGHTS
Revenue for the six months ended
- Oncology/?Immunology consolidated revenue amounted to
$162.3 million (H1-25:$143 .5m):- ELUNATE® revenue was
$47.1 million , up 40% (H1-25:$33.6m ), comprising manufacturing revenue, promotion and marketing services revenue and royalties, supported by ongoing label expansions. - SULANDA® revenue was
$18.4 million , up 45% (H1-25:$12.7m ), driven by marketing strategies focusing on key hospitals and supported by recent oncology clinical guideline upgrades. - ORPATHYS® revenue was
$13.3 million , up 48% (H1-25:$9.0m ), driven by higher manufacturing sales to AstraZeneca in preparation for the 3L MET-amplified GC launch. - FRUZAQLA® revenue was
$43.1 million (H1-25:$43.1m ), reflecting continued growth in royalties, offset by reduced manufacturing revenue compared to the prior period, driven by strong in-market sales growth following approvals/launches in 41 countries to date. - Takeda upfront, regulatory milestones and R&D services revenue were
$20.7 million (H1-25:$29.5m ), due to less R&D and regulatory support services to Takeda. - Other revenue of
$20.2 million (H1-25:$14.9m ), includes an$18.1 million milestone payment from Eli Lilly triggered byChina approval of ELUNATE® in combination with sintilimab for 2L RCC (H1-25:$11.1 million regulatory milestone from AstraZeneca following China NDA approval for SACHI).
- ELUNATE® revenue was
- Other Ventures consolidated revenue of
$116.0 million (H1-25:$134.2m ), primarily due to scaling down low-margin logistics distribution sales after considering working capital.
Net Expenses for the six months ended
- Cost of Revenue was
$152.2 million (H1-25:$167.6m ), predominantly due to a lower cost of sales related to the prescription drug distribution business. Cost of revenue as a percentage of oncology product revenue improved to 33% (H1-25: 39%) driven by enhanced productivity and efficiency. - R&D Expenses were
$78.8 million (H1-25:$72.0m ) as we initiated early-stage global clinical programs for our ATTC assets and we maintain ongoing investment in discovery to deliver sustained innovation. - S&A Expenses were
$46.5 million (H1-25:$41.6m ), driven by strong performance of our Oncology/?Immunology commercial operations and enhanced productivity. - Other Items generated net income of
$15.1 million (H1-25:$42.2m ), which mainly includes interest income and expense, foreign exchange, equity in earnings of SHPL and taxes. The decrease was mainly due to lower equity earnings from SHPL following our 45.0% equity interest disposal in 2025.
Net Income attributable to
$0.02 basic earnings per ordinary share /$0.09 basic earnings per ADS in the first half of 2026 (H1-25:$0.53 basic earnings per ordinary share /$2.65 basic earnings per ADS).
Cash, Cash Equivalents and Short-Term Investments were
Adjusted Group (non-GAAP) net cash inflow excluding financing activities in the first half of 2026 was$10.5 million mainly due to net income of$16.2 million less$5.6 million in capital expenditures (H1-25: net cash inflow of$519.1m mainly due to the$549.0m net proceeds from the partial divestment of SHPL less a$10.0m regulatory approval milestone payment and$9.2m in capital expenditures).- Net cash used in financing activities in the first half of 2026 totaled
$2.9 million mainly due to net repayments of bank borrowings (H1-25: net cash inflow of$9.3m mainly due to proceeds from bank borrowings of$8.2m ).
Foreign exchange impact: The RMB appreciated against the US dollar on average by approximately 5% during the first half of 2026, which has impacted consolidated financial results as highlighted.
Use of Non-GAAP Financial Measures and Reconciliation – References in this announcement to adjusted Group net cash flows excluding financing activities and financial measures reported at CER are based on non-GAAP financial measures. Please see the “Use of Non-GAAP Financial Measures and Reconciliation” for further information relevant to the interpretation of these financial measures and reconciliations of these financial measures to the most comparable GAAP measures, respectively.
FINANCIAL GUIDANCE
- The Company does not provide any guarantee that the statements contained in the financial guidance will materialize or that the financial results contained therein will be achieved or are likely to be achieved; and
- The Company has in the past revised its financial guidance and reference should be made to announcements it publishes regarding any updates to the financial guidance after the publication of this announcement.
FINANCIAL SUMMARY
Condensed Consolidated Balance Sheets Data
| (in $’000) | As of | As of | |
| Assets | (Unaudited) | ||
| Cash and cash equivalents and short-term investments | 1,374,817 | 1,367,275 | |
| Accounts receivable | 117,556 | 126,750 | |
| Other current assets | 61,036 | 73,317 | |
| Property, plant and equipment | 93,788 | 94,623 | |
| Investment in equity investees | 11,020 | 10,865 | |
| Other non-current assets | 78,210 | 80,267 | |
| Total assets | 1,736,427 | 1,753,097 | |
| Liabilities and shareholders’ equity | |||
| Accounts payable | 33,646 | 45,533 | |
| Other payables and accruals | 197,627 | 208,892 | |
| Bank borrowings | 94,508 | 93,160 | |
| Deferred revenue | 27,630 | 51,547 | |
| Other liabilities | 108,048 | 102,703 | |
| Total liabilities | 461,459 | 501,835 | |
| Company’s shareholders’ equity | 1,260,776 | 1,237,926 | |
| Non-controlling interests | 14,192 | 13,336 | |
| Total liabilities and shareholders’ equity | 1,736,427 | 1,753,097 | |
Condensed Consolidated Statements of Operations Data
| (Unaudited, in $’000, except share and per share data) | Six months ended | ||||
| 2026 | 2025 | ||||
| Revenue: | |||||
| Oncology/?Immunology – Marketed Products | 121,434 | 99,039 | |||
| Oncology/?Immunology – R&D | 40,887 | 44,408 | |||
| Oncology/?Immunology Consolidated Revenue | 162,321 | 143,447 | |||
| Other Ventures | 115,966 | 134,230 | |||
| Total revenue | 278,287 | 277,677 | |||
| Operating expenses: | |||||
| Cost of revenue | (152,158 | ) | (167,577 | ) | |
| Research and development expenses | (78,783 | ) | (71,990 | ) | |
| Selling and administrative expenses | (46,477 | ) | (41,624 | ) | |
| Total operating expenses | (277,418 | ) | (281,191 | ) | |
| Gain on divestment of an equity investee | — | 477,456 | |||
| Other income, net | 12,784 | 21,650 | |||
| Income before income taxes and equity in earnings of equity investees | 13,653 | 495,592 | |||
| Income tax expense | (1,209 | ) | (2,029 | ) | |
| Income tax expense – Divestment of an equity investee | — | (61,133 | ) | ||
| Equity in earnings of equity investees, net of tax | 3,798 | 23,125 | |||
| Net income | 16,242 | 455,555 | |||
| Less: Net income attributable to non-controlling interests | (314 | ) | (601 | ) | |
| Net income attributable to | 15,928 | 454,954 | |||
| Earnings per share attributable to | |||||
| – basic | 0.02 | 0.53 | |||
| – diluted | 0.02 | 0.52 | |||
| Number of shares used in per share calculation | |||||
| – basic | 865,770,498 | 857,038,725 | |||
| – diluted | 872,869,494 | 872,564,513 | |||
| Earnings per ADS attributable to | |||||
| – basic | 0.09 | 2.65 | |||
| – diluted | 0.09 | 2.61 | |||
| Number of ADSs used in per ADS calculation | |||||
| – basic | 173,154,100 | 171,407,745 | |||
| – diluted | 174,573,899 | 174,512,903 | |||
About
Contacts
| Investor Enquiries | +852 2121 8200 /ir@hutch-med.com |
| Media Enquiries | |
| FTI Consulting – | +44 20 3727 1030 /HUTCHMED@fticonsulting.com |
| +44 7771 913 902 (Mobile) / +44 7779 436 698 (Mobile) | |
| Brunswick – Zhou Yi | +852 9783 6894 (Mobile) /HUTCHMED@brunswickgroup.com |
| Nominated Advisor and Joint Broker | |
| Atholl Tweedie / Emma Earl / Rupert Dearden | +44 20 7886 2500 |
| Cavendish | Joint Broker |
| Geoff Nash / Nigel Birks | +44 20 7220 0500 |
| Deutsche Numis | Joint Broker |
| Duncan Monteith / Ramin Naji | +44 20 7545 8000 |
References
Unless the context requires otherwise, references in this announcement to the “Group,” the “Company,” “HUTCHMED,” “HUTCHMED Group,” “we,” “us,” and “our,” mean
Past Performance and Forward-Looking Statements
The performance and results of operations of the Group contained within this announcement are historical in nature, and past performance is no guarantee of future results of the Group. This announcement contains forward-looking statements within the meaning of the “safe harbor” provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by words like “will”, “expects”, “anticipates”, “future”, “intends”, “plans”, “believes”, “estimates”, “pipeline”, “could”, “potential”, “first-in-class”, “best-in-class”, “designed to”, “objective”, “guidance”, “pursue”, or similar terms, or by express or implied discussions regarding potential drug candidates, potential indications for drug candidates or by discussions of strategy, plans, expectations or intentions. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that any of our drug candidates will be approved for sale in any market, that any approvals which have been obtained will continue to remain valid and effective in the future, or that the sales of products marketed or otherwise commercialized by
In addition, this announcement contains statistical data and estimates that
Inside Information
This announcement contains inside information for the purposes of Article 7 of Regulation (EU) No 596/2014 (as it forms part of retained EU law as defined in the European Union (Withdrawal) Act 2018).
Medical Information
This announcement contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.
This announcement in its entirety is available at: http://ml.globenewswire.com/Resource/Download/031c06fc-010c-45d1-8c53-ed93a7275b6c
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