Clarifies DOMA’s Inaccuracies and the Reality of Pacira’ Efforts to Strengthen its Market Position
Urges Stockholders to Vote “FOR” the Election of Pacira’s Highly Qualified Nominees on the BLUE Proxy Card Today
The complete text of the letter mailed to stockholders is as follows:
Dear Pacira Stockholders,
As we approach our 2026 Annual Meeting of Stockholders (the “Annual Meeting”) on
As we’ve communicated with you, one of our stockholders,
Pacira today is a markedly different company from a few years ago, and our progress speaks for itself despite DOMA’s attempts to diminish it by deliberately distorting the facts.
In 2024, we strengthened our executive leadership team with the appointment of
Last year was an important, transformational year in the execution of this strategy, which resulted in meaningful progress across our business, renewed momentum and strategic clarity.
We urge you to protect your investment today and support Pacira’s continued positive momentum by voting the BLUE proxy card “FOR” each of Pacira’s three highly qualified board nominees.
PACIRA’S POSITIVE PERFORMANCE
Pacira’s renewed momentum and strategic clarity over the last 16 months is driven by the launch and execution of our 5x30 strategy for stockholder value creation. In fact, we have definitive results that show we are making significant progress to deliver sustainable value:
1) Since the launch of our 5x30 strategy, our stock is up over 31%.2
2) Pacira was profitable in 2025 and delivered strong performance including:
-
- Record total revenues of
$726.4 million ; - GAAP net income of
$7.0 million or$0.16 per basic and diluted share; - Non-GAAP net income of
$122.3 million or$2.74 per basic share and$2.65 per diluted share;3 - Record GAAP Gross Margins of 79.4%; and
- Record Non-GAAP Gross Margins of 81.2%.4
- Record total revenues of
3) Our 5x30 strategy is working:
-
- Our products treated over 2.5 million patients in 2025, reinforcing our trajectory toward helping 3 million patients annually by 2030.
- EXPAREL achieved year-over-year volume growth of 6.2% in 2025, up from 3.6% in 2024, marking progress toward our goal of double-digit compounded annual topline growth. Of note, EXPAREL volume growth achieved a meaningful lift in the second half of 2025 with volume growth of 8% over the prior year period, nearly double that of the first half of the year. Furthermore, starting in the second half of this year, we expect volume growth and sales growth to converge.
- We advanced two promising Phase 2 clinical programs – PCRX-201, our novel locally administered gene therapy for osteoarthritis (OA), and our recently in-licensed asset PCRX-2002, a complementary, long-acting, ropivacaine-based local analgesic for postsurgical pain. These programs place us on course for our goal of five novel programs by 2030, and each has the potential to deliver topline accretion as we move beyond 2030.
- We expanded our commercial reach both inside and outside the
U.S. by signing strategic collaborations with Johnson & Johnson MedTech and LG Chem, advancing us toward our goal of five partnerships by 2030. Through these collaborations we have already tripled ourU.S. commercial reach to physicians with a leading industry partner, and we see a significant addressable market with approximately 15 million people in theU.S. affected by knee OA.
We are focused on realizing value across all our products and bringing new sources of revenue online. We have made meaningful progress diversifying our portfolio beyond the

Figure 15
Beyond our existing commercial base, we continue to invest in our pipeline, to ensure the Company is positioned to drive growth beyond 2030. Based on our disciplined investments in Research and Development, we expect three key data readouts at the end of this year that have the potential for stockholder value creation.

Figure 25
In short, we believe we entered 2026 in the strongest position in our history and we are confident that we are on the right path forward. We believe we have substantial upside potential supported by our strong fundamentals and sustained growth trajectory.
PACIRA REACHED A FARSIGHTED EXPAREL SETTLEMENT, DELIVERING A POSITIVE OUTCOME FOR STOCKHOLDERS AND REINFORCING VALIDITY OF INTELLECTUAL PROPERTY STRATEGY
Pacira reached a favorable EXPAREL settlement in 2025, which we believe was a strategic win for stockholders as it gives Pacira full exclusivity into 2030 and a gradual, capped transition through 2039. That's a clear runway to execute our diversification strategy without the rapid decline and disruption normally seen with generic entry.
But don’t just take our word for it. Commentors have relayed the same sentiment.6
- “The settlement is a win for PCRX and the EXPAREL franchise, bringing needed clarity and 5-yrs of protection to potentially realize the benefits of internal drivers such as GPO contracting and NOPAIN across the surgical segments; importantly, the settlement allows the company to focus squarely on hitting their 5x30 objectives, which we believe could ultimately yield long-term pipeline growth drivers for revenues 2030+.” –
RBC Capital Markets April 7, 2025 - “We think this is clearly a positive development for PCRX, and the terms are between our base and good case scenarios for the company.” – J.P. Morgan
April 7, 2025 - “Pacira announced that settlement with
Fresenius Kabi (FRE:GR;not rated) and the would-be Gx EXPAREL Chinese manufacturer Jiangsu Hengrui (600276:CH; not rated), and the deal looks as favorable for Pacira as anyone could have reasonably hoped for, and in our view representing profound upside to the current valuation.” –H.C. Wainwright & CO.April 8, 2025 - “We think the outcome is largely neutral to slightly favorable to Pacira but ultimately gives investors the certainty they've been looking for.” –
Truist Securities April 7, 2025
Pacira stockholders should understand that the potential for additional generic competition is a common dynamic with successful products like EXPAREL. However, we have been proactive in an attempt to prevent future litigation attempts, including expanding EXPAREL’s patent estate to 21 “Orange-Book” listed patents across two families, which provide exclusivity through the mid-2040s, a significant evolution from the single patent,
DOMA’s claims about our intellectual property strategy demonstrate a fundamental lack of understanding of our business, and we remain steadfast in our belief that the EXPAREL franchise is strong and well protected from multiple directions.
PACIRA’S BOARD IS FIT FOR PURPOSE AND WORKING TO SERVE YOU, OUR VALUED STOCKHOLDERS
We want to be clear - the quality and composition of our board is a top priority.
Pacira’s recently refreshed and highly qualified board has played an essential role in overseeing the execution of our strategic priorities as well as the overall strategic direction of the Company. Furthermore, our directors have a longstanding track record of stockholder engagement.
Following the 2025 Annual Meeting of Stockholders, Pacira’s board took the following actions, further demonstrating our commitment to stockholder engagement7:
- Contacted 41 stockholders, representing 97.4% of shares outstanding; and
- Engaged 11 stockholders, where 8 out of the 11 meetings were led by independent directors, representing 56.7% of shares outstanding.
In addition, our board takes its responsibility to all stockholders incredibly seriously, and has consistently shown its responsiveness to stockholder feedback, for example we:
- Appointed five independent directors since 2023 (and nominated a sixth for election at the Annual Meeting) to bring fresh perspectives and directly address stockholder preferences;
- Separated board Chair and CEO roles in
January 2024 to instill greater accountability; - Encouraged a board member to resign from an outside board to address stockholder concerns regarding overboarding;
- Amended our bylaws to reflect the adoption of a majority voting standard for uncontested director elections, with a plurality voting standard for contested elections; and
- Evolved our executive compensation program, including introducing performance share units for 2026, refining our peer group alignment, enhancing proxy statement disclosure and reinforcing a disciplined approach to one-time awards in the context of executive compensation.
As it relates to DOMA, members of your board and executive leadership team have also met with DOMA 17 times since
Following these nominee interviews and our established vetting processes, Pacira’s board determined that none of DOMA’s nominees possess the knowledge and experience necessary to be value additive to Pacira’s board.
We urge you to support Pacira’s continued positive momentum. Vote the BLUE proxy card today “FOR” each of Pacira’s three highly qualified board nominees -
If you have questions or require assistance with voting your shares, please contact Pacira’s proxy solicitor:
Thank you for your continued support of Pacira. Sincerely,
The Pacira Board of Directors
Advisors
About Pacira
Pacira delivers innovative, non-opioid pain therapies to transform the lives of patients. Pacira has three commercial-stage non-opioid treatments: EXPAREL® (bupivacaine liposome injectable suspension), a long-acting local analgesic currently approved for infiltration, fascial plane block, and as an interscalene brachial plexus nerve block, an adductor canal nerve block, and a sciatic nerve block in the popliteal fossa for postsurgical pain management; ZILRETTA® (triamcinolone acetonide extended-release injectable suspension), an extended-release, intra-articular injection indicated for the management of osteoarthritis knee pain; and iovera®°, a novel, handheld device for delivering immediate, long-acting, drug-free pain control using precise, controlled doses of cold temperature to a targeted nerve. The company is also advancing a pipeline of clinical-stage assets for musculoskeletal pain and adjacencies, its most advanced product candidate, PCRX-201 (enekinragene inzadenovec), a novel locally administered gene therapy, is in Phase 2 clinical development for osteoarthritis of the knee. To learn more about Pacira, visit www.pacira.com.
Forward-Looking Statements
Any statements in this document about Pacira’s future expectations, plans, trends, outlook, projections and prospects, and other statements containing the words “believes,” “anticipates,” “plans,” “estimates,” “expects,” “intends,” “may,” “will,” “would,” “could,” “can” and similar expressions, constitute forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the Private Securities Litigation Reform Act of 1995, including, without limitation, statements related to: the Annual Meeting; Pacira’s board of directors and the contributions of new directors and director nominees; ‘5x30’, our growth and business strategy, our future outlook, the strength and efficacy of our intellectual property protection and patent terms, our future growth potential and future financial and operating results and trends, our plans, objectives, expectations (financial or otherwise) and intentions, including our plans with respect to the repayment of our indebtedness, anticipated product portfolio and product development programs, strategic alliances, plans with respect to the Non-Opioids Prevent Addiction in the Nation (“NOPAIN”) Act and any other statements that are not historical facts. For this purpose, any statement that is not a statement of historical fact should be considered a forward-looking statement. We cannot assure you that our estimates, assumptions and expectations will prove to have been correct. Actual results may differ materially from these indicated by such forward-looking statements as a result of various important factors, including risks relating to, among others: risks associated with acquisitions, such as the risk that the acquired businesses and/or assets will not be integrated successfully, that such integration may be more difficult, time-consuming or costly than expected or that the expected benefits of the transaction will not occur; our manufacturing and supply chain, global and
These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause Pacira’s actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by these statements. These factors include the matters discussed and referenced in the “Risk Factors” of Pacira’s most recent Annual Report on Form 10-K and in other filings that Pacira periodically makes with the
Important Additional Information Regarding Proxy Solicitation
On
Participants in the Solicitation
Pacira, its directors, director nominees, certain of its executive officers, and other employees may be deemed participants in the solicitation of proxies from stockholders in respect of the 2026 Annual Meeting. Information regarding the names of such persons and their respective interests in Pacira by security holdings or otherwise is set forth in the 2026 Proxy Statement. Please refer to the sections captioned “Director Compensation,” “Executive Compensation,” “Stock Ownership Information” and “Appendix D—Supplemental Information Regarding Participants in the Solicitation” in the 2026 Proxy Statement. To the extent holdings of Pacira’s directors, director nominees, and executive officers who may be deemed to be participants in the solicitation in Pacira’s securities have changed since the amounts described in the 2026 Proxy Statement, such changes have been reflected on Initial Statements of Beneficial Ownership of Securities on Form 3 or Statements of Changes in Beneficial Ownership of Securities on Form 4 filed with the
Additional information can also be found in Pacira’s Annual Report on Form 10-K for the year ended
Non-GAAP Financial Information
This document contains financial measures that do not comply with
These measures supplement Pacira’s financial results prepared in accordance with GAAP. Pacira management uses these measures to better analyze its financial results, estimate its future gross margin and to help make managerial decisions. In management’s opinion, these non-GAAP measures are useful to investors and other users of Pacira’s financial statements by providing greater transparency into the ongoing operating performance of Pacira and its future outlook. These measures should not be deemed to be an alternative to GAAP requirements. The non-GAAP measures presented here are also unlikely to be comparable with non-GAAP disclosures released by other companies. See the tables below for a reconciliation of GAAP to non-GAAP measures.
RECONCILIATION OF | |||
| (in Thousands,except percentages) | |||
| (Unaudited) | 2025 | ||
| GAAP Total Revenues | $ | 726,411 | |
| GAAP Gross Margin | $ | 576,662 | |
| GAAP Gross Margin Percentage | 79.4 | % | |
| Adjustments to GAAP Gross Margin: | |||
| Stock-Based Compensation | $ | 6,448 | |
| Decommissioning of Manufacturing Suite(1) | $ | 6,521 | |
| Non-GAAP Gross Margin | $ | 589,631 | |
| Non-GAAP Gross Margin Percentage | 81.2 | % | |
(1) In
| RECONCILIATION OF GAAP NET INCOME PER COMMON SHARE TO NON-GAAP NET INCOME PER COMMON SHARE AND SHARES OUTSTANDING TO NON-GAAP WEIGHTED AVERAGE DILUTED COMMON SHARES OUTSTANDING | |||
| (in Thousands, except per share amounts) | |||
| (Unaudited) | 2025 | ||
| GAAP net income | $ | 7,034 | |
| Non-GAAP adjustments: | |||
| Changes in the fair value of contingent consideration | (2,175 | ) | |
| Restructuring charges (1) | 10,195 | ||
| Acquisition-related expenses and key employee holdback (2) | 6,315 | ||
| Legal settlement (3) | 7,000 | ||
| Legal judgment and interest (4) | (28,348 | ) | |
| Impairment of acquired in-process research & development (IPR&D) (5) | 25,866 | ||
| Amortization of acquired intangible assets | 57,288 | ||
| Stock-based compensation | 57,502 | ||
| Net loss on investments | 6,811 | ||
| Loss on early extinguishment of debt | 983 | ||
| Amortization of debt discount | 157 | ||
| Tax impact of non-GAAP adjustments (6) | (26,329 | ) | |
| Total Non-GAAP adjustments | 115,265 | ||
| Non-GAAP net income | $ | 122,299 | |
| GAAP basic and diluted net income per common share | $ | 0.16 | |
| Non-GAAP basic net income per common share | $ | 2.74 | |
| Non-GAAP diluted net income per common share | $ | 2.65 | |
| Non-GAAP net income | $ | 122,299 | |
| Interest expense on convertible senior notes, net of tax (7) | 1,213 | ||
| Non-GAAP net income used for diluted earnings per share (7) | $ | 123,512 | |
| Weighted average common shares outstanding - basic | 44,566 | ||
| Weighted average common shares outstanding - diluted | 45,042 | ||
| Non-GAAP weighted average common shares outstanding - diluted (7) | 46,696 | ||
(1) In
(2) In
(3) We recognized
(4) We recognized other operating income of
(5) We recognized an impairment of
(6) The tax impact of non-GAAP adjustments is computed by: (i) applying the statutory tax rate to the income or expense adjusted items; (ii) applying a zero-tax rate to adjusted items where a valuation allowance exists; and (iii) excluding discrete tax benefits and expenses, primarily associated with stock-based compensation. For the year ended
(7) For the year ended
1
2 One day prior to announcement on
3 Non-GAAP Net Income and Non-GAAP Net Income Per Common Share are non-GAAP financial measures. See “Non-GAAP Financial Information” for the definitions of Non-GAAP Net Income and Non-GAAP Net Income Per Common Share and reconciliations to the applicable most directly comparable GAAP measure.
4 Non-GAAP Gross Margin is a non-GAAP financial measure. See “Non-GAAP Financial Information” for the definition of Non-GAAP Gross Margin and a reconciliation to the most directly comparable GAAP measure.
5 https://investor.pacira.com/static-files/234c8e60-9815-4c05-971b-199d64b572c4
6Permission to use quotes neither sought nor obtained.
7Share ownership figures based on 13F filings and 44.9 million shares of common stock outstanding as of
Photos accompanying this announcement are available at:
https://www.globenewswire.com/NewsRoom/AttachmentNg/df0aa20f-7cc2-417a-adb8-44534131eb8f
https://www.globenewswire.com/NewsRoom/AttachmentNg/c81ca57c-683f-4f34-85cc-c691f1cbb57b

Investor Contact:Source:Susan Mesco , (973) 451-4030 susan.mesco@pacira.comMedia Contact:Kim Hamilton , (973) 254-4644 kim.hamilton@pacira.com
