Greetings. Welcome to the Milestone Pharma 2Q26 Earnings Conference Call. At this time, all participants are in a listen-only mode. A question and answer session will follow the formal presentation. If anyone should require operator assistance during the conference, please press star zero on your telephone keypad. Please note this conference is being recorded. I will now turn the conference over to Michael Wood from LifeSci Advisors. Thank you, Michael. You may begin.

Thank you and good morning, everyone, and welcome to Milestone Pharmaceuticals' second quarter 2026 financial results and business update conference call. Earlier this morning, the company issued a press release providing an overview of its financial results for the quarter ended June 30th, 2026 and recent corporate highlights. The release can be accessed on the investors' media section of the company's website, milestonepharma.com. Before we begin, I would like to remind you that some of the information presented on this conference call contains forward-looking statements under the securities laws. These forward-looking statements involve substantial risks and uncertainties that could cause actual clinical programs, future results, progress timing, performances, or achievements to differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties associated with milestones, business, and factors that could cause or contribute to such differences are described in details in the company's filings with the SEC, including in the risk factors section of the annual report on Form 10-K for the year ended December 31, 2025, filed with the SEC on March 20, 2026. Speaking on the call today will be Joseph Oliveto, President and Chief Executive Officer, Lorenz Muller, Chief Commercial Officer, Chief Financial Officer and EVP of Corporate Development. In addition, Dr. David Bharucha, the company's Chief Medical Officer, will also be available during the Q&A session. I will now turn the call over to Joseph Oliveto. Please go ahead.

Thank you, Michael. Good morning, everyone, and thank you for joining us today to hear about our progress through the second quarter. Until this year, Patients experiencing sudden attacks of paroxysmal supraventricular tachycardia, or PSVT, had no FDA-approved self-administered treatment available to them. Now, a growing population of patients in the United States have cardamom in their homes, in their workplaces, in their pockets, or wherever it's convenient for them to have on hand to treat their PSVT. Today, we're excited to report on our first full financial quarter since our commercial launch in mid-February. We're seeing growing evidence that physicians, patients, and payers recognize the value of cardamom as a new treatment paradigm for PSVT. I'll start by taking you through total scripts, the number of unique prescribers, and patients filling prescriptions, and we'll report these figures for the quarter compare them to the prior quarter and add them for the first half results. Realize that the first quarter is a partial quarter and first half figures represent approximately four and a half months of promotion between mid-February and the end of June. We'll also provide an update on market access coverage and how it has changed since our last investor call in May. For the second quarter of 2026, ending June 30th, We continue to view the breadth of prescriber experience as one of the more important positive early indicators for the launch. More than 600 unique healthcare professionals wrote prescriptions for Cardamist in the second quarter compared with approximately 200 in the first quarter for a total of greater than 800 unique prescribers across the first half of the year. We recorded more than 1,200 total prescriptions in Q2 Compared with approximately 300 in the first quarter, bringing the total prescriptions for the first half of 2026 to more than 1,500. And more than 1,000 patients received cardamom in the second quarter, compared with nearly 300 in the first quarter, for a total of more than 1,300 patients in the first half of the year. As of today, we have secured formulary coverage representing more than 50% of commercially insured lives. Most of this progress of additional coverage has come very recently, specifically in July and August. During the second quarter, coverage remained relatively unchanged at approximately 25% of commercially insured lives, which we reported on at our May investor call. Our recent crossing of the 50% commercially insured mark is an important achievement, which will enable increased access to Cardamis for patients in those plans, as well as providing us with increased confidence for gaining coverage from additional plans. Lorenz will share further insights about the launch, but before turning the call over to Lorenz, I'll provide an update on the AFib-RVR program. From the start of our development of this novel compound and delivery system, our aim has been to shift appropriate acute care for tachycardias from the current treatment state, which is reactive and healthcare setting intensive, to one that is proactive and patient empowering by enabling patients to treat themselves outside the hospital. We are now at an exciting intersection of both fulfilling that promise for patients with PSVT and having begun the Registrational Phase III stage of evaluating atripomil in the broader population of patients, those who experience atrial fibrillation with rapid ventricular rate or AFib-RVR. We have begun our pivotal Phase III trial evaluating atripomil for treatment of AFib-RVR as announced in our last learnings release. Thanks to the efforts of the Milestone Clinical Team, our lead clinical sites are now active and we expect our first patients to be enrolled shortly. We believe AFib-RVR represents a substantially larger opportunity for Atripamil to help patients than it has for PSVT. Atrial fibrillation is a growing problem in the United States, estimated to impact over 10 million people. From this, we estimate an addressable population with burdensome symptomatic RVR of 3 to 4 million patients. Somewhat like PSVT, patients with AFib RVR experience symptomatic episodes and currently for AFib have limited and suboptimal self-administered treatment options. As a result, many of these episodes are managed in the emergency department using intravenous therapies or even electrical cardioversion. We're looking to leverage the strong and unique foothold that we have established in the cardiovascular space to address these current limitations. The design of our Phase III AFib study, called Rivera 301, follows the same approach that was the basis for our successful Phase III program in PSVT. Patients self-administer study medication, either a triple molar placebo in a double-blended fashion, at home in response to their symptoms using the same 70 milligram dose and repeat dose regimen that is already approved for Cardamis and PSVT. Many of the operational components of the study and many of the clinical sites are the same as those that were performed and performed well in our PSVT program. We believe this continuity between the two programs lowers our executional risk and reflects the experience we, meaning our team, the clinical investigators and our collaboration partners have built across the ATRIPAMIL program. Our regulatory approach in AFib using our phase three study is a single study supplemental new drug application or SMDA. This is an efficient registrational pathway to a potential label expansion and we will provide further updates on this program as it progresses. In addition to our progress toward an indication for AFib-RVR, we are progressing towards regulatory decisions in PSVT in Europe and China. If successful, these will expand access to atrypamil globally. Our marketing application with the European Medicines Agency, or EMA, remains on track for a decision expected in the first half of 2027. The engagement with the Chinese regulators is being carried by our partner, Everest Medicines. I will now turn the call over to Lorenz to cover our commercial progress in more detail.

Thank you, Joe, and good morning, everyone. Building on Joe's remarks, I will highlight what we are seeing six months into the launch and specifically how we are well-positioned to accelerate in the coming months. We're excited about the progress of our work towards securing commercial coverage for which is a critical goal that can define success in the first year of a drug launch. At the end of Q2, we had secured coverage for an estimated 25% of commercial lives, which primarily accounted for the early win we achieved at the end of Q1 with Express Scripts. In the week since the quarter closed, we have seen a meaningful step up in coverage. As of last week, approximately half of commercially insured lives are now covered driven by formulary decisions at United Healthcare and several other prominent commercial insurers that use either Express Scripts or OptumRx as their pharmacy benefit manager. It is important to see our focused and persistent market access work gain traction, and we remain optimistic about securing the last of the major PBMs and associated insurance providers, as well as pulling through additional plans who work with ESI and OptumRx. The receptivity among payers is an important signal. We believe it tells us that they appreciate the clinical value of Cardamist and anticipate that demand will continue to grow. As Joe mentioned at the top of the call, we're also very encouraged by the growing breadth of prescribers we've seen to date, and just as importantly, that electrophysiologists are strongly engaged in prescribing Cardamist for their patients. Recognized as the key opinion leaders in the treatment of tachycardias. These physicians represent many of the early adopters of Cardamist. Early experience among electrophysiologists is important because as awareness of Cardamist continues to grow, use and endorsement by this subspecialty will influence demand generation in general cardiology. In terms of demand generation, in Q2, we have seen steady, consistent growth in prescriptions for Cardamist. In addition to electrophysiologists, Our sales efforts have established a broad and growing receptive base of prescribers that include clinical and interventional cardiologists as well as advanced practice providers such as nurse practitioners within cardiology practices. As we move through the second half of the year, our efforts will continue to grow this base of new prescribers while simultaneously focusing on the early adopters of Cardamist with the goal of driving greater depth of prescribing encouraging the healthcare providers already using Cardamist to prescribe it more consistently across their eligible patients. A second area of our launch strategy that we are initiating is targeted patient activation. With coverage now at approximately 50% of commercially insured lives, we believe we've reached an important tipping point where patients can have greater confidence in accessing Cardamist. We've also learned from market research that when patients ask their healthcare provider about Cardamist, There is a high likelihood that they will receive it. With that foundation in place, we believe that now is the right time to begin building patient awareness through our enhanced Cardamist.com experience and targeted digital advertising. This investment will encourage interested patients to speak with their healthcare providers and download resources that make Cardamist affordable for commercially insured patients. We believe that enhanced promotion to healthcare providers as a result of learnings from the first six months of launch, combined with newly initiated patient activation efforts, will support an acceleration of demand for Cardamist in the quarters ahead. I'll now turn the call over to Amit for a review of our financials.

Thank you, Lorenz. As of June 30th, 2026, we had cash, cash equivalents, and short-term investments of $170.6 million. compared with 106 million at December 31st, 2025. We expect cash, cash equivalents and short-term investments to be sufficient to cover operating expenses and capital expenditure into the second half of 2027. Product revenue for the three months and six months ended June 30th, 2026 was 0.6 million and 0.8 million respectively. There was no product revenue recorded in the three or six month periods ended June 30th, 2025. Research and development expense net of tax credits was $3.5 million for the second quarter of 2026 compared with $3.7 million for the same period in 2025. For the six months ended June 30, 2026, research and development expense was $6.8 million compared with $8.6 million for the same period in 2025. The decrease was a result of a decrease in outside service costs related to drug development and research. Selling, general, and administrative expense was $22.6 million for the second quarter of 2026 compared with $8.9 million for the second quarter of 2025. For the six months ended June 30, 2026, selling, general, and administrative expense was $43.3 million compared with $24.4 million for the same period in 2025. The increase was a result of additional personnel costs, professional costs, and other operational expenses related to the launch of Cardamist. Net loss for the second quarter of 2026 was 28.6 million or 21 cents per share compared with a net loss of 13 million or 20 cents per share for the second quarter of 2025. For the six months ended June 30th, 2026, net loss was 54.7 million or 41 cents per share compared with 33.7 million or 51 cents per share for the same period in 2025. For further details on our financial results, please refer to our quarterly report on Form 10-Q for the quarter ended June 30th, 2026, which was filed with the SEC this morning. I will now turn the call back over to Joe for closing remarks.

Thank you, Lorenz and Amit. Today, we've reported on numbers and metrics that we are following closely and I'm sure we'll discuss further. Let's remember why we're here and the value of our product. I'd like to share some recent anecdotes we've received from the field about PSVT patients and their experience with Cardimus. This includes having received stories from patients with self-described history of quote-unquote multiple trips to the emergency department who successfully converted to normal sinus rhythm on Cardimus and without the trip to the ED. We've heard recently from a medical assistant who after she recounted the specifics of the patient's success story, which I unfortunately can't share the details, finished the note with she, meaning the patient, is excited, the doctor's excited, and I'm excited, and I needed to let you know. And another patient who actually made a special trip back to his provider's office only to share the great success he had with Cardamist. These stories serve as powerful reminders of the transformational impact we're having on patients' experience with PSVT. They lift us up and reinforce our commitment to the cardiology patient community. And we can't help but believe stories like these also lift healthcare providers up because they can offer an innovative option that their patients are excited about. In closing, the first half of the year has given us a solid foundation to build on. We have established a broad and growing receptive base of prescribers, which we believe tells us the clinical value of cardamom is resonating. We have expanded commercial coverage to roughly half of commercially insured lives and fully expect to pull through more commercial coverage. Together with continuously improving refined sales and marketing strategies, our goal is to continue to accelerate growth in the second half of the year. Looking beyond the PSVT launch, we are particularly excited about initiating our Phase III AFib-RVR study and in enrolling the first patient soon. We will share that news as soon as it's available. That concludes our remarks and we will now open the call for questions.

Thank you. We will now be conducting a question and answer session. If you would like to ask a question, please press star 1 on your telephone keypad. A confirmation tone will indicate your line is in the question queue. You may press star 2 if you would like to remove your question from the queue. For participants using speaker equipment, it may be necessary to pick up your handset before pressing the star keys. One moment, please, while we poll for questions. Our first question is from Ritu Baral with TD Cohen and Company. Please proceed with your question.

Hi, guys. This is Athena Chin on for Ritu Baral. Thanks for taking the question. I wanted to get more color on your prescribing trends especially on the 600 new or unique prescribers through Q2. What percentage of them were high volume writers versus one-time prescribers and how are you seeing the breakdown between prescribing trends between cardiologists, electrophysiologists and nurse practitioners kind of shifting throughout this launch? Thank you.

Hey, Athena. Thanks for the question. And just to come back to specific numbers, through Q2, we're at around 800 unique prescribers. That is a strength that leads us as a forward indicator for expected prescription growth going forward. And we did report that 800 unique prescribers prescribed to about 1,300 patients over that first four and a half months through the through June 30th. So just doing the math, you can see a lot of those writers are, if you will, one-time writers. We see this as a strength. As we've gotten out into the field, we've probably reached about half of our targets. Recall that we have about 10,000 high-value targets on our call list. Of those targets, we also have explained that we call on the whole office. and there's about 16,000 what we call affiliate members associated with the offices of those targets. So a call universe of about 26,000 of which we've reached about half, let's say. So of the 10,000 targets, about half have been called on, about 800 have written so far, which we think is a good number for that high value target list. and as I had said, a fair number of them were one-timers. We've also seen promotional response that Lorenz will talk about and I'll also ask him to talk about the diversity of writers but he had mentioned in the call script the value of the electrophysiologist so he'll also comment on that.

Yeah, thanks, Anthony. Regarding the mix, I mean, we're pleasantly surprised that it's a broad, not only is it a significant number of writers, but also it's a healthy mix of clinical cardiologists, interventional cardiologists, nurse practitioners, what we call APPs, but also electrophysiologists, as I alluded to on the prepared remarks. You know, we always expected EPs to treat these patients, but we didn't expect them to write as early and as broadly because, you know, let's face it, their job is to do ablations, right? And so we weren't We always expected some use, but we're seeing, I think, more than we even expected, which I think is an early sign of, you know, a good sign for the market where we've got the thought leaders that are getting experience and then going to be advocating for it. On the promotional response, we also are, obviously measure this, we're now six months in, so we're starting to get, you know, a small number of doctors that are getting, you know, five, six, seven, eight, ten calls, and we are to see real response, meaning as you get more promotion, you do get more prescriptions. And again, that's across the board. It's not isolated to EPs or cardiologists. But I can tell you that EPs have a strong promotional response, meaning when they hear about the drug, it's a calcium channel blocker, they see these patients frequently, and they have a real use case for it. So they are prescribing it relatively early in what we typically see for for cardiology launches.

Yeah. So, Athena, just to put a wrap on it, what that means for us going forward is we would still expect to see continued breadth and growth of breadth of prescribers as seen by prescribers that write after one or two calls. But given the promotional response, now it directs us to go with more frequent calling where it's appropriate and we see that there should be benefits once you get beyond, you know, five or six calls to actually have further writing. So it's a double-pronged approach that'll start going forward where depth will be added to breadth.

Got it, thank you. Our next question is from Ted Tenthoff with Piper Sandler. Please proceed with your question.

Great, thank you and congrats on the study progress and I really appreciated the patient vignettes. Joe, that's really encouraging and cool to hear because I do think these are really important therapies. I wanted to get a sense, may still be a little bit early, but just kind of any commentary you have on pricing and whether or not there's gross to net discounting that you're seeing. And then also, again, still maybe a little bit early, but any early indications on repeat use? And I'm trying to kind of get back to sort of the real world numbers that you used for annual attack rate. So thanks for that, for answering those.

Yeah, so I'll start, I'll ask Amit to add any additional cover on, you know, average selling prices. And, you know, I'll start there though. Foundationally, this is a market that, you know, hasn't had any new development, certainly on the drug side for decades. So we consciously went into this Thank you so much for joining us. Very recent 50% coverage, but through the second quarter, which is what these numbers are on, Ted, really, while we're happy to get express scripts early in the quarter and eventually see that pulled through, the second quarter, we really had relatively low coverage, if you think about it, right? 25% of commercially covered lives, commercials about half of the overall population. So we're talking about a small piece of the overall population. As a result of that, Our strategy was to allow for a fair amount of copay mitigation. And when you don't have a lot of coverage, that means a lot of denial conversion, meaning that, you know, the script is basically given away and we don't make any revenues from it. So that really swamps out your average selling price over that period while coverage is low. With Q3 now starting and we're just getting, I mean, literally in July and even just the other day, we got more coverage. July into mid-August here, that's growing down 50%. As that grows, we think that amount of denial conversion and overall copay mitigation will start to come down over time. It's hard to predict exactly when, but we still believe we got the right strategy. Let's make it easy to get the drug. Let's make it a good experience for doctors and patients when they get it. And not having a good experience means going through a lot of paperwork. We try to limit that until we can get coverage, and that's when we'll start to see increases in average selling price kick up as we get better coverage and less denial conversion.

That makes a lot of sense.

You talked about also repeat use, right? If we look at just the numbers, Q1, very early, 300 scripts, 300 patients. Q2, I guess we had... 1500 scripts over 1300 patients. So good signal that we're starting to see repeat use per patient, which is a great sign. And obviously, as time goes by, we'll see that more and more, right? We've seen it in our clinical trials. We expect that to happen in the real world as well.

Great. Excellent. Thanks for all that additional color. Thanks, Ted.

Our next question is from Mohit Bansal with Wells Fargo. Please proceed with your question.

Great, thank you very much for taking my questions and congrats on all the progress. I just wanted to understand, so a couple of questions there. So number one, I just want to understand the difference between commercial cover life, that is 25%, versus the cover lives here. Is this the step added which is an issue, which is the difference between these two or or there are any other things. And would the cover life be same as commercial cover lives at some point? Would love to get some clarification there. And the second question is, basically, so far for the 25% commercially covered lives, the kind of rebates and all, are they in the ballpark of what you were thinking before or there's some difference there? Thank you.

Great questions and I'll clarify that Mohit. It was really a simple concept. Essentially, SVT is about half of our population is under 65 and about half of our population is over 65. When that breaks down into coverage, it's actually to be very specific, a little bit more like 45% commercial, 45% Medicare, and about 10% other, which is kind of Medicaid and government type programs like that. So that is what I was talking about when I talked about the whole population. And when you think of commercially covered lives, you think about that being about half of the overall population. So when we say we have about 25% of commercially covered lives, we're talking about 25% of just that portion of the population. Medicare and stuff like that comes starting in 27, and we'll get there. And that's why we've always focused Investors, analysts, and even prescribers to really starting with commercial because we expect commercial coverage to come sooner than Medicare coverage would come and that's playing out. With regard to the rebates, the short answer is yes. We think and we've always said that we've priced this product such that with moderate rebates, we would be able to have good coverage and have reasonable out-of-pockets for patients. And at least with the initial coverage we have so far, which is now approaching 50% or now exceeded 50% of commercially covered lives, it's right in the ballpark of what we thought.

Awesome. Thank you very much. Appreciate it. Thanks.

Our next question is from Tiago Faust with Raymond James. Please proceed with your question.

Thanks for taking the question. Just kind of a follow-up on the commercial coverage improvement. So that expanded coverage, I know we're going to see more impact on that in Q4, but I'm trying to understand how can it translate to prescription, both behavior and also net revenue per patient. Is this mostly going to convert some of the prescriptions that are already being written to commercial and you're going to get a higher net revenue per prescript? Or could this actually be a trigger of better access and more beaten prescriptions because physicians can actually get a little easier access on that? And just to follow up on Rivera, because again, you are using the exact same formulation, you have an existing database, it would be an SNDA What is the remaining risks on that AFib trial? Is it going to be like the symptom endpoint, the patient identification, enrollment, trial execution? Can you just talk about some of the levers there? Thank you.

Okay. Thanks, Tiago. Three questions as I captured them there. So I think the first was around with improving coverage, how does that impact Scripts and Revenues, essentially, and it impacts both, I would say. Foundationally, I say it would have the most impact on revenues, on improved average selling prices, because as I said before, we'll just have less denial conversion associated with the products, right, which we're doing quite extensively now. So we should see, with that coverage pulled through in Q3 and impacting Q4, We should start to see eventual improvements in average selling price and better gross to nets. You're very astute, though, to ask about impacts on scripts as well, because let's face it, doctors know that new drugs come with access hurdles. And when I'm out in the field, the typical call closes with, looks like a great idea. How do I get it? And is it covered? And they fundamentally know that that involves paperwork and that involves the work of their office to get it through. And it's a soft variable. See, I can't put an exact number on it, but it's there in their minds. So we believe fully that once we, I don't know if this is exactly the time, but once we get to critical mass of coverage, Then physicians know it's going to go through. Their patients can pick it up at their local pharmacy with a reasonable out-of-pocket, and awareness of our copay card bringing a reasonable out-of-pocket down to $25 is going to go quickly, and it's not going to involve a lot of extra paperwork. So that's in their minds, and we fully believe that'll increase script growth once we start reaching a critical mass of coverage. Now, heading over to Rivera, you're exactly right. We take a lot of confidence, and I'll ask David if I miss anything here. We'll take a lot of confidence in the fact that we learned a lot from the SVT program, and we are really using a lot of those same tactics. So all the things that we really wrapped ourselves around the axel on and went, well, how to identify patients, how to train patients, how to capture data, what monitor to use, All those details that worked very well in that program are going to follow through here. AFib-RVR, though, is different, right? And I would say the main risk that we've identified for investors is that this study has two main differences to the SVT study, the first one being that the secondary endpoint is pivotal to getting the approval, and that is a patient-reported outcome. We have experience with the patient-reported outcomes in SVT, but they weren't as important an endpoint. And here, we have to double down and make sure that that patient-reported outcome performs well, and we capture the data as if it was a primary. So that's a new thing for this program. And the other main difference between, I would say, AFib-RVR program and the SVT program is those patients that misdiagnose their events. In the PSVT program, that was about 20%. 80% of the people got it correct. They thought they were in SVT and they dosed themselves for an SVT event. And about 20% of those events were mischaracterized. They were not actually SVT. They were dosing for something else. That dilution factor will play into The AFib program. So we will have to make sure that we limit that in the AFib program. We're all over it. We believe we'll do a great job there. And we've incorporated that into the powering of the study. And we'll be able to see that as the study goes along in a blinded manner. So we'll be able to adjust our tactics as we go forward. But those are the two primary differences between the AFib program and the PSVT program from a tactical standpoint. Okay, fantastic. Thanks, Joe. Thanks a lot, Tiago. Appreciate it.

So, okay.

Our next question is from Brandon Folks with HC Wainwright. Please proceed with your question.

Hi, thanks for taking my questions, and congrats on the quarter. I just want to kind of continue on the prescribing trends. You know, are you seeing prescribers undertake almost their own kind of mini patient experience trial and that they write a script, are waiting to hear back from the patient to use it more broadly, in which case we hold into the patient having an episode. And then along, carrying on, what is the physician targeting or prescribing strategy in the back half of this year and into 2027? Does it remain on growing the breadth of prescribing and then sort of at what stage of the launch do you envision focusing more on the depth of describing and seeing that as a significant growth trap. Thank you.

Okay. Thanks, Brandon. So with regard to that, I love how you put it, you know, their own patient experience trial, are they doing that in their own heads? A little bit yes and no, I'd say. We've heard two things. We have heard and seen that is not in doctors' heads, that they're willing to prescribed very broadly to a swath of patients. And we see that across both electrophysiology and cardiology. There are early adopters who see the value and are just prescribing it. And the question there is just, do they have it top of mind when they have their patients in front of them? And then is this the right patient, right? So we see that, but you're very astute to ask the question because it is very common in cardiology that they actually will wait for their own experience, see how the drug does for their patient, and then write refills or write additional patients, right? So there is a very natural tendency for that. We do see that. We have heard from some doctors. They said, let me try it on one or two patients, see how it goes, and then I'll write more. So we see that as upside for sure because the drug really has performed quite well in our view, in our experience with doctors. So just It goes to our strategy of getting it in the hands of patients. It is not like a chronic drug where they can get their experience in the next week. They have to wait for an event, so that's a little bit of a dampener for timing, but we fully expect the drug to do well and that experience to shine through. Similar to those vignettes, these things are very powerful. Maybe more than a couple of sales calls, they'll remember when a patient or a nurse walks into them and said, oh, patient so-and-so did well. We think that's going to be a multiplier effect. I'm going to ask Lorenz to expand a little further on our strategy, but the bottom line is we're doing both breadth and depth right now. And again, I'll ask him to expand a little further as to why we're doing that, particularly relative to the promotional response.

Yeah, thanks, Brandon, for the question. So, you know, early in the launch, there's always two goals, right? You want to get doctors to, you want to raise awareness first and foremost, which is a big driver early on, right? Nothing's been new in this area for 30 years, and doctors have gotten very comfortable in how they prescribe. So going in there and initially raising awareness and getting the drug, getting them excited about the drug, which has proven to be relatively straightforward because it's a calcium channel blocker. So that early signal of breadth of prescribing, we've been very pleased with, and the fact that it's been a sustained growth. It hasn't been a bolus early on, and it's flattened out. And that's the natural part of it. But because the drug isn't necessarily top of mind, Now what we're doing is now that we know where our better targets are, our reps have been out there for four to six months, they know and they've talked to their profiled offices, they know which ones are actively treating SVT, they know how many patients roughly they're treating from all their work with those practices, they can now go back and when a person has trialed, they've tried it on one patient, they'll now go back and start to increase frequency on those targets while continuing to identify new targets that are perhaps a little bit later adopting Those early adopters, they're going to be focused like a laser on those to increase their volume of prescribing. You get that repeat use, meaning not refills. That's also a part of the strategy, but making them aware that there are other patients than just the first ones they prescribe for. So it's a kind of a shift from initially doing more prospecting and understanding what the nature of the territories are and where the business is to now shifting at least some of their effort into increasing frequency to drive more use and shifting doctors from awareness to trial to usage.

Great. Thank you very much and congrats on the progress.

Once again, if you would like to ask a question, please press star 1 on your telephone keypad. Our next question is from Dennis Ding with Jefferies. Please proceed with your question.

Hey, this is Georgia Bank on the line for Dennis Ding. Congrats on the quarter and thanks for taking our questions. I had one about what you spoke about in acceleration in the second half. I guess how much of that expectation is driven by the recent improvement in coverage versus the new patient awareness initiatives and maybe can you provide more detail on what those patient activation efforts look like and when would you expect them to begin having a measurable impact on prescription growth and then separately on commercially insured lives in the U.S. now that you have 50% I guess how quickly do you expect commercial coverage to scale from here and what should be watching over the second half this year in terms of any incremental pair wins. Thank you.

Thanks, George. It's a great question, but a difficult one to answer in terms of specificity as to exactly which tactics will drive what impact on Scripps. We obviously have those internally, but we view it a little bit as a gestalt. We're six months into this launch. We've used the first six months here essentially for prospecting the market. and seeing what's working, what's not. We've saved a fair amount of dry powder for these programs and we foundationally have a belief that we will get commercial coverage. We thought we would get it sooner than most products. It seems like we're on target for that so far. Hard to say whether it'll continue to be ahead of coverage and coverage will grow specifically by the end of the year, but we're really bullish given our interactions on coverage that it's going well and what felt good with Express Scripts and United Healthcare is continuing to feel good with the others. So that's the best I could say with regard to our bullishness towards coverage coming, but exactly when it's really in their hands, not our hands. We love the value prop. I will say, and I'll ask Lorenz to expand a little bit more on the patient activation, that was gated by design for coverage. What we did not want to do was start driving patient awareness and ask patients to go into their doctors and ask about Cardamist if coverage wasn't approaching some critical mass, which we feel at least 50% of commercial coverage gives us that chip to be able to go in and start that. And as coverage grows, those patients going in will have a better experience. So maybe I'll just use that as a foundation and ask Lorenz to expand on that. as well as where the improved call targeting will help out as well.

Yeah, thanks, George, for the question. So, as Joe said, we've always focused on, you know, gaining coverage, getting physicians aware of the drug, getting experience with it, and at the right time, we felt there was a real opportunity to get patients also aware so that they go into their office, doctors, and ask for the drug. As Joe mentioned, there's a very high grant rate when a patient, both in general, in cardiology or in other specialties too, but we've actually seen it in our market research where if a patient asks for a cardamom, it's highly likely that the physician will grant that for them. So the scale of the patient activation campaign, let's be clear, what it's not is DTC. We're not going to do TV ads and all that kind of thing. We don't think the market's ready for that yet. We're doing a very targeted digital marketing campaign that involves advertising to patients where they are, whether it's social media or search or even Banner Advertising on things like WebMD and other resources so that we get the patient's attention. The payoff is to go to a website where they can get more information. Cardamist.com, as you can see, has been enhanced with a whole front end as a patient campaign. And that will allow them to be educated. And then there's some things they can do. They're encouraged to opt in to us so we can market to them so we can have a relationship with them. They're encouraged to go see their doctor and ask for Cardamist. There are resources they can download in terms of copay cards and whatnot So the idea is to make them aware and then allow them to take an action and also build a relationship with them so that we can market to them over time with things like refill reminders or reminding them to go see their doctor, etc. So that is going to be a lot of energy this second half of the year to complement everything we're doing on the physician side to continue to drive top line awareness, top of mind awareness of the doc, and continuing to see the broad set of patients in front of them that they can appropriately and write partners for.

Yeah. And lastly, I'll just add on to that, Georgia. There's also, you know, we don't talk about it much. Many investors just ask about the Salesforce. But the Salesforce comes with surround sound as well on the HCP. So HCP awareness is still something we are working towards. And, you know, we expect that to go up over time. And this surround sound, these, you know, advertising on the sites, that physicians are on where they see educational materials, understanding that there's something new for SVT I think is a powerful aspect of our program. And we've seen that putting that next to a sales representative actually improves the opportunity for a physician to write. So we'll continue to see that pull through in the second half as well.

Got it. Thank you so much. This now concludes our question and answer session. Ladies and gentlemen, thank you for your participation. This does conclude today's teleconference. Please disconnect your lines and have a wonderful day.