DSGN Design Therapeutics, Inc.
Design Therapeutics, Inc. (DSGN) Institutional Ownership
What the institutions did with DSGN last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| SR One Capital Management, LP | 6.5M | 15.1% |
| Logos Global Management LP | 3.0M | 6.9% |
| BAKER BROS. ADVISORS LP | 2.7M | 6.2% |
| Driehaus Capital Management LLC | 2.7M | 6.1% |
| BlackRock, Inc. | 2.7M | 6.1% |
| Point72 Asset Management, L.P. | 2.4M | 5.5% |
| Trails Edge Capital Partners, LP | 2.0M | 4.6% |
| Frazier Life Sciences Management, L.P. | 1.8M | 4.2% |
| Vivo Capital, LLC | 1.6M | 3.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.6M | 3.6% |
| Caption Management, LLC | 1.1M | 2.6% |
| Almitas Capital LLC | 1.0M | 2.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 958.4K | 2.2% |
| Sofinnova Investments, Inc. | 865.1K | 2.0% |
| FMR LLC | 776.5K | 1.8% |
| MORGAN STANLEY | 765.4K | 1.8% |
| STATE STREET CORP | 736.2K | 1.7% |
| Woodline Partners LP | 700.4K | 1.6% |
| DIMENSIONAL FUND ADVISORS LP | 694.7K | 1.6% |
| GOLDMAN SACHS GROUP INC | 656.6K | 1.5% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 565.6K | 1.3% |
| ACADIAN ASSET MANAGEMENT LLC | 537.5K | 1.2% |
| Siren, L.L.C. | 523.2K | 1.2% |
| Qube Research & Technologies Ltd | 437.1K | 1.0% |
| RENAISSANCE TECHNOLOGIES LLC | 387.9K | 0.9% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Sold Out | 3.0M | 0 | -3.0M |
| Frazier Life Sciences Management, L.P. | New | 0 | 1.8M | +1.8M |
| Trails Edge Capital Partners, LP | Increased | 852.0K | 2.0M | +1.1M |
| Logos Global Management LP | Increased | 2.0M | 3.0M | +1.1M |
| Caption Management, LLC | Increased | 86.7K | 1.1M | +1.0M |
| Driehaus Capital Management LLC | Increased | 1.7M | 2.7M | +916.1K |
| Sofinnova Investments, Inc. | New | 0 | 865.1K | +865.1K |
| Kynam Capital Management, LP | Sold Out | 784.6K | 0 | -784.6K |
| BlackRock, Inc. | Increased | 2.1M | 2.7M | +526.3K |
| Siren, L.L.C. | New | 0 | 523.2K | +523.2K |
| Almitas Capital LLC | Reduced | 1.5M | 1.0M | -503.4K |
| Qube Research & Technologies Ltd | Increased | 34.2K | 437.1K | +402.9K |
| Point72 Asset Management, L.P. | Reduced | 2.7M | 2.4M | -356.3K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Increased | 289.4K | 565.6K | +276.2K |
| D. E. Shaw & Co., Inc. | Reduced | 470.3K | 195.6K | -274.6K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 692.5K | 958.4K | +265.9K |
| DIMENSIONAL FUND ADVISORS LP | Increased | 431.8K | 694.7K | +262.9K |
| Woodline Partners LP | Reduced | 961.5K | 700.4K | -261.1K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 1.3M | 1.6M | +221.2K |
| Eversept Partners, LP | New | 0 | 190.0K | +190.0K |
| KVP Capital Advisors, LP | New | 0 | 185.0K | +185.0K |
| PRUDENTIAL FINANCIAL INC | Increased | 45.8K | 224.2K | +178.4K |
| J. Goldman & Co LP | New | 0 | 176.8K | +176.8K |
| GOLDMAN SACHS GROUP INC | Increased | 504.7K | 656.6K | +151.9K |
| MARSHALL WACE, LLP | Sold Out | 151.0K | 0 | -151.0K |
| CITADEL ADVISORS LLC | Reduced | 231.5K | 82.0K | -149.5K |
| ACUTA CAPITAL PARTNERS, LLC | Increased | 145.9K | 282.6K | +136.7K |
| Invesco Ltd. | Reduced | 141.9K | 21.4K | -120.5K |
| Lynx1 Capital Management LP | Sold Out | 119.5K | 0 | -119.5K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 138.6K | 251.4K | +112.9K |
| KENNEDY CAPITAL MANAGEMENT LLC | Increased | 271.6K | 384.0K | +112.5K |
| Balyasny Asset Management L.P. | New | 0 | 111.1K | +111.1K |
| SEI INVESTMENTS CO | Reduced | 133.2K | 22.7K | -110.5K |
| MORGAN STANLEY | Increased | 656.6K | 765.4K | +108.9K |
| JANE STREET GROUP, LLC | Sold Out | 103.9K | 0 | -103.9K |
| DAFNA Capital Management LLC | New | 0 | 102.6K | +102.6K |
| Elmind Capital, LP | Reduced | 207.9K | 107.9K | -100.0K |
| BAKER BROS. ADVISORS LP | Increased | 2.6M | 2.7M | +92.5K |
| ALGERT GLOBAL LLC | Increased | 204.7K | 296.1K | +91.3K |
| Trexquant Investment LP | Reduced | 117.1K | 28.2K | -89.0K |
| SummitTX Capital, L.P. | New | 0 | 80.7K | +80.7K |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | 616.5K | 537.5K | -79.0K |
| Informed Momentum Co LLC | Sold Out | 78.9K | 0 | -78.9K |
| STATE STREET CORP | Increased | 659.6K | 736.2K | +76.6K |
| Squarepoint Ops LLC | Reduced | 86.1K | 29.6K | -56.5K |
| China Universal Asset Management Co., Ltd. | Increased | 35.1K | 89.9K | +54.8K |
| NORTHERN TRUST CORP | Increased | 300.3K | 353.2K | +52.9K |
| AQR CAPITAL MANAGEMENT LLC | Increased | 26.0K | 71.1K | +45.2K |
| Verdad Advisers, LP | Reduced | 92.3K | 47.6K | -44.8K |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | 50.3K | 5.8K | -44.5K |
| BARCLAYS PLC | Reduced | 55.8K | 11.7K | -44.1K |
| Russell Investments Group, Ltd. | Increased | 25.4K | 66.9K | +41.4K |
| ExodusPoint Capital Management, LP | New | 0 | 41.3K | +41.3K |
| MILLENNIUM MANAGEMENT LLC | Increased | 108.9K | 147.7K | +38.8K |
| XTX Topco Ltd | Reduced | 60.9K | 22.4K | -38.6K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 195.7K | 230.2K | +34.5K |
| Susquehanna Portfolio Strategies, LLC | New | 0 | 33.4K | +33.4K |
| AMERIPRISE FINANCIAL INC | Increased | 35.0K | 67.6K | +32.6K |
| OPPENHEIMER & CO INC | New | 0 | 32.1K | +32.1K |
| RAYMOND JAMES FINANCIAL INC | Increased | 108.4K | 138.5K | +30.1K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.