SPRB Spruce Biosciences, Inc.
Spruce Biosciences, Inc. (SPRB) Institutional Ownership
What the institutions did with SPRB last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| AIGH Capital Management LLC | 250.0K | 12.5% |
| ORBIMED ADVISORS LLC | 200.0K | 10.0% |
| BlackRock, Inc. | 187.8K | 9.4% |
| MILLENNIUM MANAGEMENT LLC | 161.0K | 8.0% |
| Ikarian Capital, LLC | 121.4K | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 119.3K | 5.9% |
| Alyeska Investment Group, L.P. | 81.7K | 4.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 70.5K | 3.5% |
| ADAR1 Capital Management, LLC | 67.7K | 3.4% |
| Cable Car Capital, LP | 60.0K | 3.0% |
| CITADEL ADVISORS LLC | 51.9K | 2.6% |
| STATE STREET CORP | 50.5K | 2.5% |
| BOOTHBAY FUND MANAGEMENT, LLC | 42.1K | 2.1% |
| STEMPOINT CAPITAL LP | 41.4K | 2.1% |
| Eversept Partners, LP | 40.0K | 2.0% |
| Carlyle Group Inc. | 38.6K | 1.9% |
| GOLDMAN SACHS GROUP INC | 32.3K | 1.6% |
| Affinity Asset Advisors, LLC | 30.0K | 1.5% |
| DIADEMA PARTNERS LP | 30.0K | 1.5% |
| Stonepine Capital Management, LLC | 28.8K | 1.4% |
| Point72 Asset Management, L.P. | 28.3K | 1.4% |
| Quinn Opportunity Partners LLC | 26.8K | 1.3% |
| UBS Group AG | 23.4K | 1.2% |
| ExodusPoint Capital Management, LP | 22.0K | 1.1% |
| NORTHERN TRUST CORP | 21.1K | 1.1% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| AIGH Capital Management LLC | New | 0 | 250.0K | +250.0K |
| ORBIMED ADVISORS LLC | New | 0 | 200.0K | +200.0K |
| BlackRock, Inc. | Increased | 16.9K | 187.8K | +170.9K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 18.3K | 119.3K | +101.0K |
| Cable Car Capital, LP | New | 0 | 60.0K | +60.0K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 12.9K | 70.5K | +57.7K |
| MILLENNIUM MANAGEMENT LLC | Increased | 111.9K | 161.0K | +49.1K |
| WELLINGTON MANAGEMENT GROUP LLP | Sold Out | 48.8K | 0 | -48.8K |
| STATE STREET CORP | Increased | 5.4K | 50.5K | +45.1K |
| Eversept Partners, LP | New | 0 | 40.0K | +40.0K |
| Affinity Asset Advisors, LLC | New | 0 | 30.0K | +30.0K |
| Alyeska Investment Group, L.P. | Increased | 51.7K | 81.7K | +30.0K |
| Stonepine Capital Management, LLC | New | 0 | 28.8K | +28.8K |
| STEMPOINT CAPITAL LP | Increased | 12.7K | 41.4K | +28.7K |
| Point72 Asset Management, L.P. | New | 0 | 28.3K | +28.3K |
| Balyasny Asset Management L.P. | Reduced | 40.0K | 12.1K | -27.9K |
| GOLDMAN SACHS GROUP INC | Increased | 5.5K | 32.3K | +26.8K |
| NORTHERN TRUST CORP | New | 0 | 21.1K | +21.1K |
| DIADEMA PARTNERS LP | Increased | 10.0K | 30.0K | +20.0K |
| Knott David M Jr | New | 0 | 20.0K | +20.0K |
| Rosalind Advisors, Inc. | New | 0 | 20.0K | +20.0K |
| UBS Group AG | Increased | 3.9K | 23.4K | +19.5K |
| AMERIPRISE FINANCIAL INC | New | 0 | 18.8K | +18.8K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | New | 0 | 18.5K | +18.5K |
| CITADEL ADVISORS LLC | Reduced | 70.0K | 51.9K | -18.1K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 5.5K | 18.4K | +12.8K |
| Squadron Capital Management LLC | Sold Out | 12.2K | 0 | -12.2K |
| ADAR1 Capital Management, LLC | Increased | 58.6K | 67.7K | +9.1K |
| DIMENSIONAL FUND ADVISORS LP | New | 0 | 8.8K | +8.8K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | New | 0 | 7.2K | +7.2K |
| Bank of New York Mellon Corp | New | 0 | 6.8K | +6.8K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | New | 0 | 5.9K | +5.9K |
| Persistent Asset Partners Ltd | Increased | 2.5K | 7.7K | +5.1K |
| RENAISSANCE TECHNOLOGIES LLC | New | 0 | 4.7K | +4.7K |
| Resolute Capital Asset Partners LLC | Sold Out | 4.0K | 0 | -4.0K |
| Pale Fire Capital SE | New | 0 | 3.8K | +3.8K |
| RHUMBLINE ADVISERS | New | 0 | 3.5K | +3.5K |
| SkyView Investment Advisors, LLC | New | 0 | 3.0K | +3.0K |
| MORGAN STANLEY | Increased | 1.4K | 4.4K | +3.0K |
| DEUTSCHE BANK AG\ | New | 0 | 2.7K | +2.7K |
| WELLS FARGO & COMPANY/MN | New | 0 | 2.3K | +2.3K |
| NEW YORK STATE COMMON RETIREMENT FUND | New | 0 | 1.9K | +1.9K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | New | 0 | 1.3K | +1.3K |
| JPMORGAN CHASE & CO | New | 0 | 1.1K | +1.1K |
| Police & Firemen's Retirement System of New Jersey | New | 0 | 864 | +864 |
| BARCLAYS PLC | New | 0 | 674 | +674 |
| BNP PARIBAS FINANCIAL MARKETS | New | 0 | 453 | +453 |
| FMR LLC | New | 0 | 343 | +343 |
| CITIGROUP INC | Increased | 939 | 1.3K | +326 |
| Legal & General Group Plc | New | 0 | 264 | +264 |
| Ameritas Investment Partners, Inc. | New | 0 | 247 | +247 |
| Russell Investments Group, Ltd. | New | 0 | 217 | +217 |
| SBI Securities Co., Ltd. | New | 0 | 201 | +201 |
| Sound Income Strategies, LLC | Sold Out | 200 | 0 | -200 |
| ROYAL BANK OF CANADA | New | 0 | 166 | +166 |
| JONES FINANCIAL COMPANIES LLLP | Reduced | 193 | 30 | -163 |
| Tower Research Capital LLC (TRC) | Increased | 140 | 246 | +106 |
| Sterling Capital Management LLC | New | 0 | 43 | +43 |
| Friedenthal Financial | New | 0 | 7 | +7 |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.