SPRO Spero Therapeutics, Inc.
Spero Therapeutics, Inc. (SPRO) Institutional Ownership
What the institutions did with SPRO last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| GSK plc | 9.2M | 42.8% |
| Pfizer Inc | 2.4M | 11.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.0M | 9.5% |
| RENAISSANCE TECHNOLOGIES LLC | 947.9K | 4.4% |
| Alphabet Inc. | 890.0K | 4.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 759.3K | 3.5% |
| BlackRock, Inc. | 594.4K | 2.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 566.3K | 2.6% |
| RAYMOND JAMES FINANCIAL INC | 521.7K | 2.4% |
| TWO SIGMA INVESTMENTS, LP | 382.8K | 1.8% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 333.0K | 1.6% |
| VANGUARD FIDUCIARY TRUST CO | 287.6K | 1.3% |
| GSA CAPITAL PARTNERS LLP | 285.9K | 1.3% |
| DIMENSIONAL FUND ADVISORS LP | 274.8K | 1.3% |
| GOLDMAN SACHS GROUP INC | 257.0K | 1.2% |
| STATE STREET CORP | 214.8K | 1.0% |
| JANE STREET GROUP, LLC | 158.1K | 0.7% |
| UBS Group AG | 139.7K | 0.7% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 114.8K | 0.5% |
| NORTHERN TRUST CORP | 108.3K | 0.5% |
| Point72 Asset Management, L.P. | 104.4K | 0.5% |
| Ionic Capital Management LLC | 102.7K | 0.5% |
| Federation des caisses Desjardins du Quebec | 91.9K | 0.4% |
| Shay Capital LLC | 72.4K | 0.3% |
| Invesco Ltd. | 64.2K | 0.3% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| Anson Funds Management LP | Sold Out | 843.9K | 0 | -843.9K |
| RAYMOND JAMES FINANCIAL INC | New | 0 | 521.7K | +521.7K |
| TWO SIGMA INVESTMENTS, LP | Reduced | 885.6K | 382.8K | -502.8K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Increased | 333.1K | 759.3K | +426.2K |
| CITADEL ADVISORS LLC | Sold Out | 376.5K | 0 | -376.5K |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | 0 | 333.0K | +333.0K |
| GOLDMAN SACHS GROUP INC | New | 0 | 257.0K | +257.0K |
| DIMENSIONAL FUND ADVISORS LP | Increased | 29.8K | 274.8K | +245.1K |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | 1.2M | 947.9K | -241.3K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 1.8M | 2.0M | +236.3K |
| Squarepoint Ops LLC | Sold Out | 194.3K | 0 | -194.3K |
| BlackRock, Inc. | Increased | 433.2K | 594.4K | +161.2K |
| MARSHALL WACE, LLP | Sold Out | 157.1K | 0 | -157.1K |
| UBS Group AG | Increased | 3.0K | 139.7K | +136.7K |
| Ionic Capital Management LLC | Reduced | 195.9K | 102.7K | -93.2K |
| Federation des caisses Desjardins du Quebec | New | 0 | 91.9K | +91.9K |
| JANE STREET GROUP, LLC | Increased | 106.3K | 158.1K | +51.8K |
| XTX Topco Ltd | New | 0 | 50.5K | +50.5K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 519.9K | 566.3K | +46.4K |
| Point72 Asset Management, L.P. | Increased | 59.7K | 104.4K | +44.7K |
| Quadrature Capital Ltd | Sold Out | 40.1K | 0 | -40.1K |
| OMERS ADMINISTRATION Corp | Sold Out | 39.4K | 0 | -39.4K |
| AMERICAN CENTURY COMPANIES INC | New | 0 | 36.8K | +36.8K |
| AXXCESS WEALTH MANAGEMENT, LLC | New | 0 | 32.5K | +32.5K |
| DLK Investment Management, LLC | New | 0 | 31.4K | +31.4K |
| SIMPLEX TRADING, LLC | Increased | 30.3K | 61.3K | +31.0K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 264.1K | 287.6K | +23.5K |
| OPPENHEIMER & CO INC | New | 0 | 22.9K | +22.9K |
| Schonfeld Strategic Advisors LLC | Sold Out | 20.3K | 0 | -20.3K |
| MILLENNIUM MANAGEMENT LLC | New | 0 | 19.3K | +19.3K |
| Invesco Ltd. | Increased | 45.4K | 64.2K | +18.9K |
| Assenagon Asset Management S.A. | Increased | 18.6K | 37.3K | +18.6K |
| Verdad Advisers, LP | Increased | 33.5K | 51.3K | +17.9K |
| Susquehanna Portfolio Strategies, LLC | New | 0 | 17.6K | +17.6K |
| Torrey Growth & Income Advisors | Sold Out | 17.0K | 0 | -17.0K |
| OCCUDO QUANTITATIVE STRATEGIES LP | Sold Out | 16.4K | 0 | -16.4K |
| INTREPID FAMILY OFFICE LLC | Sold Out | 16.3K | 0 | -16.3K |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | New | 0 | 16.1K | +16.1K |
| Qube Research & Technologies Ltd | New | 0 | 13.6K | +13.6K |
| NORTHERN TRUST CORP | Reduced | 121.0K | 108.3K | -12.7K |
| SG Americas Securities, LLC | New | 0 | 11.3K | +11.3K |
| GROUP ONE TRADING LLC | New | 0 | 10.9K | +10.9K |
| TWO SIGMA SECURITIES, LLC | New | 0 | 10.6K | +10.6K |
| PRUDENTIAL FINANCIAL INC | New | 0 | 10.4K | +10.4K |
| CITIGROUP INC | Reduced | 19.1K | 9.6K | -9.5K |
| GSA CAPITAL PARTNERS LLP | Increased | 278.3K | 285.9K | +7.6K |
| MORGAN STANLEY | Reduced | 4.6K | 914 | -3.6K |
| FNY Investment Advisers, LLC | Increased | 5.3K | 8.3K | +3.0K |
| Shay Capital LLC | Increased | 70.4K | 72.4K | +2.0K |
| ROYAL BANK OF CANADA | New | 0 | 2.0K | +2.0K |
| FMR LLC | New | 0 | 300 | +300 |
| Rialto Wealth Management, LLC | New | 0 | 172 | +172 |
| BNP PARIBAS FINANCIAL MARKETS | Sold Out | 40 | 0 | -40 |
| SBI Securities Co., Ltd. | Increased | 9 | 13 | +4 |
| Caitong International Asset Management Co., Ltd | Sold Out | 3 | 0 | -3 |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.