UPB Upstream Bio, Inc.
Upstream Bio, Inc. (UPB) Institutional Ownership
What the institutions did with UPB last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 8.2M | 16.1% |
| ORBIMED ADVISORS LLC | 5.7M | 11.3% |
| NORGES BANK | 3.8M | 7.5% |
| BlackRock, Inc. | 3.8M | 7.4% |
| Decheng Capital LLC | 2.7M | 5.4% |
| ENAVATE SCIENCES GP, LLC | 2.5M | 4.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.9M | 3.7% |
| MILLENNIUM MANAGEMENT LLC | 1.1M | 2.3% |
| D. E. Shaw & Co., Inc. | 1.0M | 2.0% |
| JPMORGAN CHASE & CO | 1.0M | 2.0% |
| Qube Research & Technologies Ltd | 978.5K | 1.9% |
| Parkman Healthcare Partners LLC | 935.2K | 1.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 931.3K | 1.8% |
| SEB Asset Management AB | 878.5K | 1.7% |
| Woodline Partners LP | 831.5K | 1.6% |
| STATE STREET CORP | 766.3K | 1.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 712.7K | 1.4% |
| Y-Intercept (Hong Kong) Ltd | 693.6K | 1.4% |
| Bain Capital Life Sciences Investors, LLC | 600.9K | 1.2% |
| AQR CAPITAL MANAGEMENT LLC | 544.9K | 1.1% |
| MORGAN STANLEY | 524.6K | 1.0% |
| BNP PARIBAS FINANCIAL MARKETS | 511.5K | 1.0% |
| Walleye Capital LLC | 498.5K | 1.0% |
| Trexquant Investment LP | 466.4K | 0.9% |
| Point72 Asset Management, L.P. | 453.0K | 0.9% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| FEDERATED HERMES, INC. | Sold Out | 979.8K | 0 | -979.8K |
| Pictet Asset Management Holding SA | Sold Out | 733.4K | 0 | -733.4K |
| HSBC HOLDINGS PLC | Reduced | 640.3K | 10.8K | -629.5K |
| JPMORGAN CHASE & CO | Increased | 463.0K | 1.0M | +549.0K |
| Walleye Capital LLC | New | 0 | 498.5K | +498.5K |
| AQR CAPITAL MANAGEMENT LLC | Increased | 72.2K | 544.9K | +472.7K |
| Nantahala Capital Management, LLC | Sold Out | 400.0K | 0 | -400.0K |
| BNP PARIBAS FINANCIAL MARKETS | Increased | 126.0K | 511.5K | +385.5K |
| BlackRock, Inc. | Increased | 3.4M | 3.8M | +382.7K |
| SAMSARA BIOCAPITAL, LLC | Reduced | 736.0K | 353.7K | -382.3K |
| Qube Research & Technologies Ltd | Increased | 619.3K | 978.5K | +359.2K |
| BANK OF AMERICA CORP /DE/ | Increased | 48.5K | 391.8K | +343.3K |
| Y-Intercept (Hong Kong) Ltd | Reduced | 1.0M | 693.6K | -307.1K |
| DIMENSIONAL FUND ADVISORS LP | Increased | 80.0K | 381.6K | +301.6K |
| Alyeska Investment Group, L.P. | Sold Out | 298.3K | 0 | -298.3K |
| Trexquant Investment LP | Increased | 176.7K | 466.4K | +289.8K |
| Voleon Capital Management LP | New | 0 | 285.2K | +285.2K |
| Point72 Asset Management, L.P. | Increased | 178.2K | 453.0K | +274.8K |
| Bain Capital Life Sciences Investors, LLC | Reduced | 867.2K | 600.9K | -266.3K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | New | 0 | 253.1K | +253.1K |
| Squarepoint Ops LLC | Increased | 44.6K | 290.9K | +246.3K |
| Prosight Management, LP | Sold Out | 241.1K | 0 | -241.1K |
| D. E. Shaw & Co., Inc. | Increased | 820.5K | 1.0M | +215.6K |
| MILLENNIUM MANAGEMENT LLC | Increased | 937.3K | 1.1M | +206.5K |
| TCG Crossover Management, LLC | Sold Out | 181.1K | 0 | -181.1K |
| ACADIAN ASSET MANAGEMENT LLC | New | 0 | 175.1K | +175.1K |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Increased | 185.1K | 357.8K | +172.7K |
| HRT FINANCIAL LP | New | 0 | 170.6K | +170.6K |
| Parkman Healthcare Partners LLC | Increased | 786.8K | 935.2K | +148.5K |
| SPHERA FUNDS MANAGEMENT LTD. | Reduced | 358.0K | 219.7K | -138.3K |
| ALGERT GLOBAL LLC | New | 0 | 118.6K | +118.6K |
| Jump Financial, LLC | Reduced | 319.4K | 223.2K | -96.2K |
| GOLDMAN SACHS GROUP INC | Reduced | 316.6K | 246.9K | -69.7K |
| RENAISSANCE TECHNOLOGIES LLC | Increased | 62.1K | 131.3K | +69.2K |
| MARSHALL WACE, LLP | Sold Out | 66.8K | 0 | -66.8K |
| Schonfeld Strategic Advisors LLC | Increased | 161.3K | 225.8K | +64.4K |
| FMR LLC | Increased | 8.1M | 8.2M | +61.3K |
| STATE STREET CORP | Increased | 705.4K | 766.3K | +61.0K |
| DEUTSCHE BANK AG\ | Increased | 180.9K | 241.4K | +60.6K |
| EntryPoint Capital, LLC | Increased | 73.6K | 129.4K | +55.9K |
| Man Group plc | Increased | 21.2K | 73.8K | +52.7K |
| ExodusPoint Capital Management, LP | Reduced | 91.4K | 41.0K | -50.4K |
| Brevan Howard Capital Management LP | New | 0 | 50.4K | +50.4K |
| Russell Investments Group, Ltd. | Increased | 3.6K | 47.5K | +43.9K |
| Virtus Investment Advisers, LLC | Increased | 10.0K | 53.6K | +43.6K |
| Allspring Global Investments Holdings, LLC | New | 0 | 43.2K | +43.2K |
| TWO SIGMA INVESTMENTS, LP | New | 0 | 42.3K | +42.3K |
| NORTHERN TRUST CORP | Increased | 261.0K | 297.3K | +36.4K |
| CITIGROUP INC | Increased | 5.1K | 40.3K | +35.3K |
| ADAR1 Capital Management, LLC | Sold Out | 35.0K | 0 | -35.0K |
| XTX Topco Ltd | Increased | 209.3K | 242.3K | +33.1K |
| Aquatic Capital Management LLC | Sold Out | 31.5K | 0 | -31.5K |
| GSA CAPITAL PARTNERS LLP | Increased | 39.2K | 69.3K | +30.1K |
| Bleakley Financial Group, LLC | Sold Out | 28.9K | 0 | -28.9K |
| MORGAN STANLEY | Reduced | 552.6K | 524.6K | -28.0K |
| Quantbot Technologies LP | Increased | 663 | 28.2K | +27.5K |
| TUDOR INVESTMENT CORP ET AL | Sold Out | 26.4K | 0 | -26.4K |
| MARTINGALE ASSET MANAGEMENT L P | Sold Out | 26.2K | 0 | -26.2K |
| VICTORY CAPITAL MANAGEMENT INC | Sold Out | 25.9K | 0 | -25.9K |
| STATE OF WISCONSIN INVESTMENT BOARD | Reduced | 41.7K | 17.1K | -24.6K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.