UPB Upstream Bio, Inc.
Upstream Bio, Inc. (UPB) Institutional Ownership
What the institutions did with UPB last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
Sign in or subscribeLargest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 8.2M | 16.1% |
| ORBIMED ADVISORS LLC | 5.7M | 11.3% |
| NORGES BANK | 3.8M | 7.5% |
| BlackRock, Inc. | 3.8M | 7.4% |
| Decheng Capital LLC | 2.7M | 5.4% |
| ENAVATE SCIENCES GP, LLC | 2.5M | 4.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.9M | 3.7% |
| MILLENNIUM MANAGEMENT LLC | 1.1M | 2.3% |
| D. E. Shaw & Co., Inc. | 1.0M | 2.0% |
| JPMORGAN CHASE & CO | 1.0M | 2.0% |
| Qube Research & Technologies Ltd | 978.5K | 1.9% |
| Parkman Healthcare Partners LLC | 935.2K | 1.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 931.3K | 1.8% |
| SEB Asset Management AB | 878.5K | 1.7% |
| Woodline Partners LP | 831.5K | 1.6% |
| STATE STREET CORP | 766.3K | 1.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 712.7K | 1.4% |
| Y-Intercept (Hong Kong) Ltd | 693.6K | 1.4% |
| Bain Capital Life Sciences Investors, LLC | 600.9K | 1.2% |
| AQR CAPITAL MANAGEMENT LLC | 544.9K | 1.1% |
| MORGAN STANLEY | 524.6K | 1.0% |
| BNP PARIBAS FINANCIAL MARKETS | 511.5K | 1.0% |
| Walleye Capital LLC | 498.5K | 1.0% |
| Trexquant Investment LP | 466.4K | 0.9% |
| Point72 Asset Management, L.P. | 453.0K | 0.9% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| FEDERATED HERMES, INC. | Sold Out | 979.8K | 0 | -979.8K |
| Pictet Asset Management Holding SA | Sold Out | 733.4K | 0 | -733.4K |
| HSBC HOLDINGS PLC | Reduced | 640.3K | 10.8K | -629.5K |
| JPMORGAN CHASE & CO | Increased | 463.0K | 1.0M | +549.0K |
| Walleye Capital LLC | New | 0 | 498.5K | +498.5K |
| AQR CAPITAL MANAGEMENT LLC | Increased | 72.2K | 544.9K | +472.7K |
| Nantahala Capital Management, LLC | Sold Out | 400.0K | 0 | -400.0K |
| BNP PARIBAS FINANCIAL MARKETS | Increased | 126.0K | 511.5K | +385.5K |
| BlackRock, Inc. | Increased | 3.4M | 3.8M | +382.7K |
| SAMSARA BIOCAPITAL, LLC | Reduced | 736.0K | 353.7K | -382.3K |
| Qube Research & Technologies Ltd | Increased | 619.3K | 978.5K | +359.2K |
| BANK OF AMERICA CORP /DE/ | Increased | 48.5K | 391.8K | +343.3K |
| Y-Intercept (Hong Kong) Ltd | Reduced | 1.0M | 693.6K | -307.1K |
| DIMENSIONAL FUND ADVISORS LP | Increased | 80.0K | 381.6K | +301.6K |
| Alyeska Investment Group, L.P. | Sold Out | 298.3K | 0 | -298.3K |
| Trexquant Investment LP | Increased | 176.7K | 466.4K | +289.8K |
| Voleon Capital Management LP | New | 0 | 285.2K | +285.2K |
| Point72 Asset Management, L.P. | Increased | 178.2K | 453.0K | +274.8K |
| Bain Capital Life Sciences Investors, LLC | Reduced | 867.2K | 600.9K | -266.3K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | New | 0 | 253.1K | +253.1K |
| Squarepoint Ops LLC | Increased | 44.6K | 290.9K | +246.3K |
| Prosight Management, LP | Sold Out | 241.1K | 0 | -241.1K |
| D. E. Shaw & Co., Inc. | Increased | 820.5K | 1.0M | +215.6K |
| MILLENNIUM MANAGEMENT LLC | Increased | 937.3K | 1.1M | +206.5K |
| TCG Crossover Management, LLC | Sold Out | 181.1K | 0 | -181.1K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.