UPB Upstream Bio, Inc.
Upstream Bio, Inc. (UPB) Institutional Ownership
What the institutions did with UPB last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended September 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 8.2M | 63.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 972.6K | 7.6% |
| SEB Asset Management AB | 878.5K | 6.9% |
| Y-Intercept (Hong Kong) Ltd | 642.6K | 5.0% |
| DIMENSIONAL FUND ADVISORS LP | 374.8K | 2.9% |
| ACADIAN ASSET MANAGEMENT LLC | 370.4K | 2.9% |
| Squarepoint Ops LLC | 275.7K | 2.2% |
| BARCLAYS PLC | 198.2K | 1.5% |
| UBS Group AG | 158.1K | 1.2% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 132.8K | 1.0% |
| Bank of New York Mellon Corp | 97.1K | 0.8% |
| Nuveen, LLC | 87.0K | 0.7% |
| ALPS ADVISORS INC | 72.0K | 0.6% |
| Simplify Asset Management Inc. | 62.1K | 0.5% |
| Russell Investments Group, Ltd. | 48.1K | 0.4% |
| Allspring Global Investments Holdings, LLC | 44.9K | 0.4% |
| RHUMBLINE ADVISERS | 42.4K | 0.3% |
| CITIGROUP INC | 35.7K | 0.3% |
| STRS OHIO | 30.6K | 0.2% |
| DEUTSCHE BANK AG\ | 28.9K | 0.2% |
| Savant Capital, LLC | 18.2K | 0.1% |
| Creative Planning | 15.5K | 0.1% |
| VOYA INVESTMENT MANAGEMENT LLC | 10.8K | 0.1% |
| China Universal Asset Management Co., Ltd. | 10.0K | 0.1% |
| Police & Firemen's Retirement System of New Jersey | 9.5K | 0.1% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| DEUTSCHE BANK AG\ | Reduced | 241.4K | 28.9K | -212.6K |
| ACADIAN ASSET MANAGEMENT LLC | Increased | 175.1K | 370.4K | +195.3K |
| BARCLAYS PLC | Increased | 29.2K | 198.2K | +169.0K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Increased | 22.4K | 132.8K | +110.4K |
| UBS Group AG | Reduced | 234.7K | 158.1K | -76.6K |
| Y-Intercept (Hong Kong) Ltd | Reduced | 693.6K | 642.6K | -51.0K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 931.3K | 972.6K | +41.3K |
| SEI INVESTMENTS CO | Sold Out | 20.0K | 0 | -20.0K |
| IEQ CAPITAL, LLC | Sold Out | 19.5K | 0 | -19.5K |
| FMR LLC | Increased | 8.2M | 8.2M | +18.7K |
| STRS OHIO | Increased | 12.0K | 30.6K | +18.6K |
| Savant Capital, LLC | New | 0 | 18.2K | +18.2K |
| ALPS ADVISORS INC | Increased | 55.2K | 72.0K | +16.8K |
| Squarepoint Ops LLC | Reduced | 290.9K | 275.7K | -15.2K |
| Creative Planning | Reduced | 28.5K | 15.5K | -13.0K |
| Bank of New York Mellon Corp | Increased | 85.7K | 97.1K | +11.4K |
| VOYA INVESTMENT MANAGEMENT LLC | New | 0 | 10.8K | +10.8K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | Sold Out | 10.0K | 0 | -10.0K |
| DIMENSIONAL FUND ADVISORS LP | Reduced | 381.6K | 374.8K | -6.8K |
| KLP KAPITALFORVALTNING AS | Sold Out | 5.9K | 0 | -5.9K |
| CITIGROUP INC | Reduced | 40.3K | 35.7K | -4.6K |
| SIMPLEX TRADING, LLC | Increased | 20 | 3.1K | +3.1K |
| Parallel Advisors, LLC | New | 0 | 3.1K | +3.1K |
| Nuveen, LLC | Increased | 84.8K | 87.0K | +2.2K |
| Global Retirement Partners, LLC | Sold Out | 1.9K | 0 | -1.9K |
| Allspring Global Investments Holdings, LLC | Increased | 43.2K | 44.9K | +1.8K |
| NISA INVESTMENT ADVISORS, LLC | Reduced | 4.3K | 2.7K | -1.5K |
| PNC Financial Services Group, Inc. | Increased | 387 | 1.9K | +1.5K |
| China Universal Asset Management Co., Ltd. | Increased | 8.7K | 10.0K | +1.3K |
| Caitong International Asset Management Co., Ltd | New | 0 | 1.2K | +1.2K |
| Russell Investments Group, Ltd. | Increased | 47.5K | 48.1K | +587 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | Increased | 965 | 1.5K | +580 |
| GAMMA Investing LLC | Increased | 1.2K | 1.6K | +464 |
| Mirae Asset Global Investments Co., Ltd. | Increased | 2.4K | 2.8K | +365 |
| SJS Investment Consulting Inc. | Increased | 76 | 383 | +307 |
| US BANCORP \DE\ | Sold Out | 264 | 0 | -264 |
| ROTHSCHILD INVESTMENT LLC | Reduced | 287 | 30 | -257 |
| SIGNATUREFD, LLC | New | 0 | 242 | +242 |
| Physician Wealth Advisors, Inc. | Sold Out | 160 | 0 | -160 |
| IFP Advisors, Inc | Reduced | 242 | 90 | -152 |
| GF FUND MANAGEMENT CO. LTD. | Increased | 1.1K | 1.2K | +100 |
| Farther Finance Advisors, LLC | Reduced | 353 | 254 | -99 |
| RHUMBLINE ADVISERS | Increased | 42.4K | 42.4K | +61 |
| Essential Partners LLC | Reduced | 146 | 95 | -51 |
| EverSource Wealth Advisors, LLC | Reduced | 272 | 238 | -34 |
| Sterling Capital Management LLC | Increased | 710 | 740 | +30 |
| Provenance Wealth Advisors, LLC | New | 0 | 30 | +30 |
| Covestor Ltd | Reduced | 39 | 24 | -15 |
| Clearstead Advisors, LLC | Sold Out | 15 | 0 | -15 |
| Capital Advisors, Ltd. LLC | New | 0 | 11 | +11 |
| Silver Grove Financial Group, Inc. | Increased | 28 | 33 | +5 |
| Root Financial Partners, LLC | New | 0 | 3 | +3 |
| True Wealth Design, LLC | New | 0 | 2 | +2 |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.