AMLX Amylyx Pharmaceuticals, Inc.
Amylyx Pharmaceuticals, Inc. (AMLX) Institutional Ownership
What the institutions did with AMLX last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 16.7M | 14.5% |
| BlackRock, Inc. | 8.8M | 7.6% |
| PERCEPTIVE ADVISORS LLC | 8.3M | 7.2% |
| TCG Crossover Management, LLC | 6.2M | 5.4% |
| Commodore Capital LP | 5.7M | 4.9% |
| Jupiter Topco LLC | 5.2M | 4.5% |
| Saturn V Capital Management LP | 4.6M | 4.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4.2M | 3.7% |
| MORGAN STANLEY | 3.1M | 2.7% |
| Driehaus Capital Management LLC | 3.0M | 2.6% |
| First Light Asset Management, LLC | 3.0M | 2.6% |
| FRANKLIN RESOURCES INC | 3.0M | 2.6% |
| GOLDMAN SACHS GROUP INC | 2.9M | 2.5% |
| STATE STREET CORP | 2.6M | 2.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 2.3M | 2.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.9M | 1.6% |
| JPMORGAN CHASE & CO | 1.9M | 1.6% |
| Siren, L.L.C. | 1.5M | 1.3% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.3M | 1.1% |
| 683 Capital Management, LLC | 1.3M | 1.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.1M | 0.9% |
| Alyeska Investment Group, L.P. | 1.1M | 0.9% |
| Almitas Capital LLC | 974.9K | 0.8% |
| Nantahala Capital Management, LLC | 973.4K | 0.8% |
| DIMENSIONAL FUND ADVISORS LP | 902.5K | 0.8% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| JPMORGAN CHASE & CO | Increased | 159.7K | 1.9M | +1.7M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | 3.6M | 1.9M | -1.7M |
| Almitas Capital LLC | Reduced | 2.1M | 974.9K | -1.1M |
| Alyeska Investment Group, L.P. | New | 0 | 1.1M | +1.1M |
| GREAT POINT PARTNERS LLC | Reduced | 1.8M | 700.0K | -1.1M |
| MORGAN STANLEY | Increased | 2.2M | 3.1M | +955.3K |
| STEMPOINT CAPITAL LP | Reduced | 1.3M | 384.3K | -955.1K |
| BARCLAYS PLC | Reduced | 971.9K | 56.3K | -915.6K |
| Aberdeen Group plc | New | 0 | 737.7K | +737.7K |
| DEUTSCHE BANK AG\ | Reduced | 1.3M | 557.9K | -709.8K |
| Jones Hill Capital LP | Reduced | 1.6M | 894.1K | -704.7K |
| FRANKLIN RESOURCES INC | Increased | 2.3M | 3.0M | +688.7K |
| BANK OF AMERICA CORP /DE/ | Reduced | 1.3M | 821.8K | -508.8K |
| ADAR1 Capital Management, LLC | Reduced | 1.0M | 494.4K | -506.2K |
| Nantahala Capital Management, LLC | Increased | 535.7K | 973.4K | +437.7K |
| TWO SIGMA INVESTMENTS, LP | Increased | 161.9K | 593.4K | +431.5K |
| Nearwater Capital Markets, Ltd | New | 0 | 425.0K | +425.0K |
| Balyasny Asset Management L.P. | Reduced | 1.1M | 685.0K | -422.3K |
| Logos Global Management LP | Reduced | 700.0K | 350.0K | -350.0K |
| Trexquant Investment LP | New | 0 | 349.4K | +349.4K |
| JUPITER ASSET MANAGEMENT LTD | Reduced | 592.7K | 274.9K | -317.7K |
| Ensign Peak Advisors, Inc | New | 0 | 305.4K | +305.4K |
| JANE STREET GROUP, LLC | New | 0 | 299.6K | +299.6K |
| Saturn V Capital Management LP | Increased | 4.3M | 4.6M | +274.2K |
| FIRST TRUST ADVISORS LP | New | 0 | 254.6K | +254.6K |
| Siren, L.L.C. | Increased | 1.2M | 1.5M | +250.6K |
| 683 Capital Management, LLC | Reduced | 1.5M | 1.3M | -250.5K |
| STATE STREET CORP | Increased | 2.4M | 2.6M | +240.2K |
| CITADEL ADVISORS LLC | Reduced | 411.5K | 178.7K | -232.8K |
| GOLDMAN SACHS GROUP INC | Increased | 2.6M | 2.9M | +232.2K |
| Parkman Healthcare Partners LLC | Reduced | 621.5K | 398.8K | -222.7K |
| EVENTIDE ASSET MANAGEMENT, LLC | Reduced | 1.5M | 1.3M | -186.4K |
| ORBIMED ADVISORS LLC | New | 0 | 183.4K | +183.4K |
| First Light Asset Management, LLC | Reduced | 3.2M | 3.0M | -167.4K |
| Cormorant Asset Management, LP | Reduced | 350.0K | 200.0K | -150.0K |
| Connor, Clark & Lunn Investment Management Ltd. | Reduced | 868.3K | 721.0K | -147.3K |
| AMERIPRISE FINANCIAL INC | New | 0 | 125.5K | +125.5K |
| Walleye Capital LLC | Increased | 61.7K | 186.6K | +124.9K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 2.2M | 2.3M | +124.4K |
| Lighthouse Investment Partners, LLC | New | 0 | 122.9K | +122.9K |
| Ikarian Capital, LLC | New | 0 | 117.5K | +117.5K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 944.8K | 1.1M | +116.8K |
| Squarepoint Ops LLC | Sold Out | 114.9K | 0 | -114.9K |
| Point72 Asset Management, L.P. | Sold Out | 106.5K | 0 | -106.5K |
| D. E. Shaw & Co., Inc. | Increased | 74.2K | 174.3K | +100.1K |
| Affinity Asset Advisors, LLC | New | 0 | 99.0K | +99.0K |
| FEDERATED HERMES, INC. | Increased | 363.5K | 462.2K | +98.7K |
| FMR LLC | Increased | 16.6M | 16.7M | +97.4K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 4.1M | 4.2M | +82.6K |
| Quantinno Capital Management LP | New | 0 | 80.9K | +80.9K |
| 1492 Capital Management LLC | New | 0 | 79.8K | +79.8K |
| Nuveen, LLC | Increased | 264.9K | 330.5K | +65.6K |
| SEI INVESTMENTS CO | Reduced | 85.3K | 19.8K | -65.5K |
| Corient Private Wealth LP | New | 0 | 59.3K | +59.3K |
| Moody Aldrich Partners LLC | New | 0 | 57.8K | +57.8K |
| SG Americas Securities, LLC | New | 0 | 55.3K | +55.3K |
| Informed Momentum Co LLC | Sold Out | 53.3K | 0 | -53.3K |
| WELLS FARGO & COMPANY/MN | Increased | 75.1K | 128.2K | +53.1K |
| UBS Group AG | Reduced | 324.3K | 271.9K | -52.4K |
| NORTHERN TRUST CORP | Increased | 779.9K | 831.7K | +51.8K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.