AXSM Axsome Therapeutics, Inc.

NASDAQ
$220.75

Axsome Therapeutics, Inc. (AXSM) Insider Activity

What the officers, directors and large holders did with their own shares. Only open-market purchases and sales count toward the totals — grants, option exercises and shares withheld for tax are compensation mechanics, not decisions, and they're listed separately below.

30D 90D 6M 1Y
Insider signal In line Selling ran in line with AXSM's own trailing one-year pace, with 100% of sale value under a prearranged plan.
Cluster activity 0 buyers in the last 30 days 0 buyers in the last 90 days 2 sellers in the last 90 days
Insiders buying
0
0 transactions
Insiders selling
8
41 transactions
Purchases
$0
0 shares
Sales
$150.2M
892,933 shares
Net activity
-$150.2M
purchases less sales

How much of that selling was preplanned? 100% planned / 0% discretionary

10b5-1 plan sales $150.2M 41 transactions · 892,933 shares
Discretionary sales $0 0 transactions · 0 shares

Largest single sale: $13.5M.

Where they traded

Buy Sell Dot area is proportional to transaction value.

Last open-market purchase: September 8, 2025 — 1.0 years ago, by Coleman Mark .

Recent open-market activity

Date Insider Role Action Shares Price Value Held after
Jacobson Mark L. Chief Operating Officer Sell 10b5-1 10,000 $208.65 $2.1M None left
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 4,660 $213.95 $997.0K 7,229 −39.2% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 45,004 $212.01 $9.5M 7,229 −86.2% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 49,666 $240.25 $11.9M 7,229 −87.3% of holding
JEFFS ROGER Director Sell 10b5-1 286 $249.12 $71.2K 58,367 −0.5% of holding
Coleman Mark Director Sell 10b5-1 643 $249.00 $160.1K 30,389 −2.1% of holding
Mahony Susan Director Sell 10b5-1 300 $246.18 $73.9K 829 −26.6% of holding
JEFFS ROGER Director Sell 10b5-1 286 $246.18 $70.4K 58,653 −0.5% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 49,670 $241.01 $12.0M 7,229 −87.3% of holding
Pizzie Nick Chief Financial Officer Sell 10b5-1 33,000 $240.09 $7.9M 42,867 −43.5% of holding
Mahony Susan Director Sell 10b5-1 300 $237.21 $71.2K 1,129 −21% of holding
Coleman Mark Director Sell 10b5-1 5,537 $223.39 $1.2M 29,603 −15.8% of holding
Coleman Mark Director Sell 10b5-1 6,000 $230.30 $1.4M 35,140 −14.6% of holding
Coleman Mark Director Sell 10b5-1 6,000 $233.46 $1.4M 41,140 −12.7% of holding
Jacobson Mark L. Chief Operating Officer Sell 10b5-1 233 $228.18 $53.2K None left
Jacobson Mark L. Chief Operating Officer Sell 10b5-1 4,517 $227.94 $1.0M None left
Maizel Ari Chief Commercial Officer Sell 10b5-1 7,500 $182.42 $1.4M None left
Jacobson Mark L. Chief Operating Officer Sell 10b5-1 35,378 $161.88 $5.7M None left
Coleman Mark Director Sell 10b5-1 25,000 $161.11 $4.0M 47,140 −34.7% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 32,410 $185.60 $6.0M 7,229 −81.8% of holding
Pizzie Nick Chief Financial Officer Sell 10b5-1 12,000 $187.92 $2.3M 42,588 −22% of holding
Maizel Ari Chief Commercial Officer Sell 10b5-1 7,500 $184.44 $1.4M None left
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 31,261 $170.38 $5.3M 7,229 −81.2% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 29,450 $172.33 $5.1M 7,229 −80.3% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 78,703 $171.28 $13.5M 7,229 −91.6% of holding
Saad Mark E 2 fills Director Sell 10b5-1 37,577 $165.18 $6.2M 10,002 −79% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 10,558 $148.18 $1.6M 7,229 −59.4% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 20,163 $146.94 $3.0M 7,229 −73.6% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 49,252 $144.59 $7.1M 7,229 −87.2% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 21,775 $134.49 $2.9M 7,229 −75.1% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 50,459 $133.79 $6.8M 7,229 −87.5% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 91,705 $132.34 $12.1M 7,229 −92.7% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 12,774 $118.84 $1.5M 7,229 −63.9% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 13,390 $118.77 $1.6M 7,229 −64.9% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 19,220 $120.17 $2.3M 7,229 −72.7% of holding
Jacobson Mark L. Chief Operating Officer Sell 10b5-1 10,000 $115.96 $1.2M None left
Jacobson Mark L. 2 fills Chief Operating Officer Sell 10b5-1 45,783 $114.48 $5.2M None left
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 19,719 $114.19 $2.3M 7,229 −73.2% of holding
TABUTEAU HERRIOT Chief Executive Officer Sell 10b5-1 15,254 $117.37 $1.8M 7,229 −67.8% of holding

Form 4s are due within two business days of a transaction, so this is close to real time — unlike the quarterly 13F data on the Institutional tab. A single large sale often reflects a prearranged 10b5-1 plan rather than a fresh view, so read a pattern of sales rather than any one of them.