DFTX Definium Therapeutics, Inc.
Definium Therapeutics, Inc. (DFTX) Institutional Ownership
What the institutions did with DFTX last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| BlackRock, Inc. | 11.2M | 9.8% |
| Avoro Capital Advisors LLC | 7.2M | 6.3% |
| Driehaus Capital Management LLC | 6.8M | 6.0% |
| Jupiter Topco LLC | 5.6M | 4.9% |
| Capital World Investors | 5.4M | 4.7% |
| FMR LLC | 4.8M | 4.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.7M | 4.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 3.6M | 3.2% |
| STATE STREET CORP | 3.1M | 2.7% |
| Capital International Investors | 3.0M | 2.6% |
| Octagon Capital Advisors LP | 3.0M | 2.6% |
| WELLINGTON MANAGEMENT GROUP LLP | 2.9M | 2.6% |
| Deep Track Capital, LP | 2.8M | 2.4% |
| Commodore Capital LP | 2.0M | 1.7% |
| ALLIANCEBERNSTEIN L.P. | 1.8M | 1.6% |
| GOLDMAN SACHS GROUP INC | 1.8M | 1.6% |
| CITADEL ADVISORS LLC | 1.7M | 1.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.6M | 1.4% |
| RA CAPITAL MANAGEMENT, L.P. | 1.5M | 1.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.5M | 1.3% |
| Siren, L.L.C. | 1.4M | 1.2% |
| MARSHALL WACE, LLP | 1.3M | 1.1% |
| NORTHERN TRUST CORP | 1.2M | 1.0% |
| AMERIPRISE FINANCIAL INC | 1.1M | 1.0% |
| Nuveen, LLC | 1.1M | 1.0% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| Capital World Investors | New | 0 | 5.4M | +5.4M |
| PRICE T ROWE ASSOCIATES INC /MD/ | Increased | 70.0K | 4.7M | +4.6M |
| Capital International Investors | New | 0 | 3.0M | +3.0M |
| FMR LLC | Increased | 1.8M | 4.8M | +2.9M |
| BlackRock, Inc. | Increased | 8.5M | 11.2M | +2.8M |
| Avoro Capital Advisors LLC | Increased | 5.0M | 7.2M | +2.2M |
| Trails Edge Capital Partners, LP | Sold Out | 1.7M | 0 | -1.7M |
| ALLIANCEBERNSTEIN L.P. | Increased | 91.7K | 1.8M | +1.7M |
| WELLINGTON MANAGEMENT GROUP LLP | Increased | 1.3M | 2.9M | +1.6M |
| RA CAPITAL MANAGEMENT, L.P. | New | 0 | 1.5M | +1.5M |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 2.5M | 3.6M | +1.1M |
| ArrowMark Colorado Holdings LLC | Reduced | 1.6M | 564.1K | -1.0M |
| Driehaus Capital Management LLC | Increased | 5.9M | 6.8M | +933.4K |
| Polar Capital Holdings Plc | New | 0 | 777.3K | +777.3K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 872.7K | 1.6M | +775.8K |
| Candriam S.C.A. | Reduced | 1.3M | 614.4K | -679.2K |
| STATE STREET CORP | Increased | 2.5M | 3.1M | +593.5K |
| MILLENNIUM MANAGEMENT LLC | Reduced | 846.9K | 266.1K | -580.8K |
| NEUBERGER BERMAN GROUP LLC | Increased | 133.4K | 687.5K | +554.2K |
| BAMCO INC /NY/ | New | 0 | 520.1K | +520.1K |
| STEMPOINT CAPITAL LP | Reduced | 651.0K | 137.1K | -513.8K |
| Octagon Capital Advisors LP | Increased | 2.4M | 3.0M | +510.0K |
| Siren, L.L.C. | Increased | 919.5K | 1.4M | +500.0K |
| FRANKLIN RESOURCES INC | New | 0 | 486.2K | +486.2K |
| Catalio Capital Management, LP | Reduced | 1.0M | 562.7K | -475.3K |
| ORBIMED ADVISORS LLC | Reduced | 804.0K | 365.4K | -438.6K |
| GREAT POINT PARTNERS LLC | New | 0 | 425.0K | +425.0K |
| Nuveen, LLC | Increased | 698.1K | 1.1M | +407.2K |
| Boxer Capital Management, LLC | Increased | 598.5K | 998.5K | +400.0K |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | 0 | 400.0K | +400.0K |
| Cormorant Asset Management, LP | New | 0 | 400.0K | +400.0K |
| ASSETMARK, INC | New | 0 | 396.5K | +396.5K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 1.1M | 1.5M | +389.5K |
| Balyasny Asset Management L.P. | Reduced | 1.3M | 897.7K | -376.6K |
| NORTHERN TRUST CORP | Increased | 799.0K | 1.2M | +370.3K |
| Duquesne Family Office LLC | New | 0 | 356.6K | +356.6K |
| CITADEL ADVISORS LLC | Increased | 1.3M | 1.7M | +355.1K |
| Patient Square Capital LP | Sold Out | 331.0K | 0 | -331.0K |
| Point72 Asset Management, L.P. | Increased | 175.5K | 484.0K | +308.5K |
| Holocene Advisors, LP | Reduced | 1.1M | 796.6K | -295.4K |
| AWM Investment Company, Inc. | Reduced | 1.1M | 784.8K | -292.1K |
| TWO SIGMA INVESTMENTS, LP | Reduced | 1.2M | 921.8K | -279.8K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Increased | 808.7K | 1.1M | +274.9K |
| DEUTSCHE BANK AG\ | Reduced | 411.8K | 142.9K | -268.9K |
| JANE STREET GROUP, LLC | Sold Out | 260.2K | 0 | -260.2K |
| Qube Research & Technologies Ltd | Increased | 426.1K | 682.9K | +256.8K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 575.9K | 827.7K | +251.8K |
| Woodline Partners LP | Increased | 752.8K | 1.0M | +250.8K |
| Deep Track Capital, LP | Reduced | 3.0M | 2.8M | -250.0K |
| Trexquant Investment LP | New | 0 | 233.2K | +233.2K |
| TD Asset Management Inc | New | 0 | 209.5K | +209.5K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Increased | 2.4K | 211.2K | +208.8K |
| SEB Asset Management AB | New | 0 | 208.3K | +208.3K |
| Tri Locum Partners LP | Reduced | 369.6K | 163.0K | -206.6K |
| AMERIPRISE FINANCIAL INC | Increased | 966.6K | 1.1M | +181.8K |
| EMERALD ADVISERS, LLC | New | 0 | 178.8K | +178.8K |
| Aberdeen Group plc | New | 0 | 175.0K | +175.0K |
| SUPERSTRING CAPITAL MANAGEMENT LP | Reduced | 351.5K | 188.3K | -163.2K |
| LMR Partners LLP | New | 0 | 150.2K | +150.2K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | 1.2M | 1.0M | -150.0K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.