KPTI Karyopharm Therapeutics Inc
Karyopharm Therapeutics Inc (KPTI) Institutional Ownership
What the institutions did with KPTI last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1.9M | 8.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5M | 7.0% |
| ACORN CAPITAL ADVISORS, LLC | 1.5M | 7.0% |
| GOLDMAN SACHS GROUP INC | 1.4M | 6.5% |
| BlackRock, Inc. | 1.4M | 6.5% |
| Kalehua Capital Management LLC | 1.4M | 6.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 959.0K | 4.4% |
| Catalio Capital Management, LP | 940.9K | 4.3% |
| Avidity Partners Management LP | 924.5K | 4.2% |
| T. Rowe Price Investment Management, Inc. | 786.3K | 3.6% |
| TWO SIGMA INVESTMENTS, LP | 695.3K | 3.2% |
| NEA Management Company, LLC | 576.8K | 2.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 531.2K | 2.4% |
| Ghisallo Capital Management LLC | 500.0K | 2.3% |
| Soleus Capital Management, L.P. | 440.0K | 2.0% |
| UBS Group AG | 353.5K | 1.6% |
| STATE STREET CORP | 326.0K | 1.5% |
| Affinity Asset Advisors, LLC | 312.5K | 1.4% |
| Brevan Howard Capital Management LP | 309.8K | 1.4% |
| MILLENNIUM MANAGEMENT LLC | 305.7K | 1.4% |
| Boxer Capital Management, LLC | 302.5K | 1.4% |
| Davidson Kempner Capital Management LP | 300.0K | 1.4% |
| ACADIAN ASSET MANAGEMENT LLC | 299.0K | 1.4% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 297.5K | 1.4% |
| Eversept Partners, LP | 276.2K | 1.3% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| Commodore Capital LP | Sold Out | 2.0M | 0 | -2.0M |
| Kalehua Capital Management LLC | New | 0 | 1.4M | +1.4M |
| ACORN CAPITAL ADVISORS, LLC | Increased | 287.8K | 1.5M | +1.2M |
| BlackRock, Inc. | Increased | 244.9K | 1.4M | +1.2M |
| T. Rowe Price Investment Management, Inc. | Reduced | 1.5M | 786.3K | -755.8K |
| Ikarian Capital, LLC | Sold Out | 733.4K | 0 | -733.4K |
| NEA Management Company, LLC | New | 0 | 576.8K | +576.8K |
| TWO SIGMA INVESTMENTS, LP | Increased | 151.2K | 695.3K | +544.0K |
| Ghisallo Capital Management LLC | New | 0 | 500.0K | +500.0K |
| GOLDMAN SACHS GROUP INC | Increased | 947.6K | 1.4M | +477.1K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 206.1K | 531.2K | +325.1K |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | 0 | 297.5K | +297.5K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | 1.8M | 1.5M | -285.0K |
| STATE STREET CORP | Increased | 80.7K | 326.0K | +245.2K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 739.7K | 959.0K | +219.2K |
| BOOTHBAY FUND MANAGEMENT, LLC | Sold Out | 213.8K | 0 | -213.8K |
| JPMORGAN CHASE & CO | Increased | 471 | 207.6K | +207.1K |
| GROUP ONE TRADING LLC | Sold Out | 191.5K | 0 | -191.5K |
| BNP PARIBAS FINANCIAL MARKETS | Increased | 84 | 188.0K | +188.0K |
| Affinity Asset Advisors, LLC | Reduced | 500.0K | 312.5K | -187.5K |
| MORGAN STANLEY | Increased | 18.6K | 202.5K | +183.9K |
| Jump Financial, LLC | Reduced | 262.1K | 94.0K | -168.1K |
| UBS Group AG | Increased | 194.0K | 353.5K | +159.5K |
| BARCLAYS PLC | Increased | 7.4K | 165.9K | +158.5K |
| ADAR1 Capital Management, LLC | Sold Out | 136.7K | 0 | -136.7K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | New | 0 | 134.8K | +134.8K |
| NORTHERN TRUST CORP | Increased | 38.6K | 160.0K | +121.5K |
| MILLENNIUM MANAGEMENT LLC | Reduced | 420.6K | 305.7K | -114.9K |
| XTX Topco Ltd | Reduced | 164.4K | 53.3K | -111.2K |
| Brevan Howard Capital Management LP | Increased | 212.4K | 309.8K | +97.5K |
| Engineers Gate Manager LP | Reduced | 112.4K | 34.0K | -78.5K |
| Invesco Ltd. | Increased | 16.7K | 90.3K | +73.6K |
| JANE STREET GROUP, LLC | Reduced | 105.9K | 33.2K | -72.7K |
| Balyasny Asset Management L.P. | Sold Out | 70.7K | 0 | -70.7K |
| Trexquant Investment LP | Reduced | 257.9K | 188.4K | -69.5K |
| J. Goldman & Co LP | New | 0 | 67.5K | +67.5K |
| Squarepoint Ops LLC | New | 0 | 63.8K | +63.8K |
| Tetragon Partners GP Ltd | Sold Out | 53.0K | 0 | -53.0K |
| CITADEL ADVISORS LLC | New | 0 | 52.1K | +52.1K |
| ACADIAN ASSET MANAGEMENT LLC | Increased | 249.0K | 299.0K | +50.0K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Increased | 13.4K | 61.9K | +48.5K |
| Bank of New York Mellon Corp | Increased | 11.4K | 57.3K | +45.9K |
| DAFNA Capital Management LLC | Sold Out | 45.8K | 0 | -45.8K |
| Catalio Capital Management, LP | Increased | 897.7K | 940.9K | +43.1K |
| Birchview Capital, LP | Reduced | 84.0K | 43.0K | -41.0K |
| Nuveen, LLC | New | 0 | 37.9K | +37.9K |
| Zimmer Partners, LP | Sold Out | 37.5K | 0 | -37.5K |
| SILVERBACK ASSET MANAGEMENT LLC | Reduced | 65.0K | 30.0K | -35.0K |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | New | 0 | 33.3K | +33.3K |
| CITIGROUP INC | Increased | 4.9K | 37.9K | +33.0K |
| TORONTO DOMINION BANK | New | 0 | 30.9K | +30.9K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 114.9K | 145.4K | +30.5K |
| BANK OF AMERICA CORP /DE/ | Increased | 19.5K | 49.9K | +30.5K |
| Centiva Capital, LP | Sold Out | 30.2K | 0 | -30.2K |
| Susquehanna Portfolio Strategies, LLC | Increased | 25.0K | 54.5K | +29.5K |
| ExodusPoint Capital Management, LP | New | 0 | 26.6K | +26.6K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Sold Out | 24.1K | 0 | -24.1K |
| SIMPLEX TRADING, LLC | New | 0 | 24.1K | +24.1K |
| RHUMBLINE ADVISERS | New | 0 | 23.5K | +23.5K |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | New | 0 | 23.3K | +23.3K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.