KPTI Karyopharm Therapeutics Inc

NASDAQ
$1.79

Karyopharm Therapeutics Inc (KPTI) Hedge Fund Activity

This view isolates hedge funds from the broader institutional ownership shown on the Institutional tab. A pension fund tracking an index may have no view on a stock; when a hedge fund builds or exits a position, that decision can carry information. This page measures those changes. Positions as of June 30, 2026.

Based on quarterly 13F long-equity filings. Changes compare reported quarter-end positions; filings can be reported up to 45 days later and do not represent a fund's complete exposure.

Hedge fund breadth
+0.00
10 buyers / 10 sellers
MIXED
Funds compared
24
funds with comparable KPTI positions
19 current holders · 17 prior-quarter holders
Net share change
+150.5K
+1.37M added, -1.22M cut
Position activity
7 new 3 increased 5 reduced 5 exited

Most significant moves

Ranked by conviction, not size — how much of the fund's own book the position represents, how far it moved, and what kind of fund made it.

Fund Action Shares changed Change Est. value Portfolio wt. Score
CITADEL ADVISORS LLC Quant New +52.1K — $508.7K 0.0% 58
Ghisallo Capital Management Long/Short New +500.0K — $4.9M 0.1% 57
Balyasny Asset Management L.P. Sold Out -70.7K -100.0% $691.2K 0.0% 57
ADAR1 Capital Management Long/Short Growth Sold Out -136.7K -100.0% $1.3M 0.0% 55
Squarepoint Ops LLC Quant New +63.8K — $623.3K 0.0% 54
Zimmer Partners Long/Short Sold Out -37.5K -100.0% $366.4K 0.0% 54
TWO SIGMA INVESTMENTS, LP Quant Increased +544.0K +359.7% $5.3M 0.0% 53
Quadrature Capital Quant New +10.3K — $100.6K 0.0% 52
ExodusPoint Capital Management Long/Short Quant New +26.6K — $259.7K 0.0% 52
Boothbay Fund Management Sold Out -213.8K -100.0% $2.1M 0.0% 51

Most significant buyers

By move score, not size.

  • CITADEL ADVISORS LLC New · +52.1K
  • Ghisallo Capital Management New · +500.0K
  • Squarepoint Ops LLC New · +63.8K
  • TWO SIGMA INVESTMENTS, LP Increased · +544.0K
  • Quadrature Capital New · +10.3K

Most significant sellers

By move score, not size.

  • Balyasny Asset Management L.P. Sold Out · -70.7K
  • ADAR1 Capital Management Sold Out · -136.7K
  • Zimmer Partners Sold Out · -37.5K
  • Boothbay Fund Management Sold Out · -213.8K
  • Centiva Capital Sold Out · -30.2K

Hedge fund positions

Fund Tier Shares Previous Change Change % Portfolio wt. Action Score
CITADEL ADVISORS LLC 1 52.1K 0 +52.1K — 0.0% New 58
Ghisallo Capital Management 2 500.0K 0 +500.0K — 0.1% New 57
Balyasny Asset Management L.P. 2 0 70.7K -70.7K -100.0% 0.0% Sold Out 57
ADAR1 Capital Management 3 0 136.7K -136.7K -100.0% 0.0% Sold Out 55
Squarepoint Ops LLC 2 63.8K 0 +63.8K — 0.0% New 54
Zimmer Partners 2 0 37.5K -37.5K -100.0% 0.0% Sold Out 54
TWO SIGMA INVESTMENTS, LP 2 695.3K 151.2K +544.0K +359.7% 0.0% Increased 53
Quadrature Capital 3 10.3K 0 +10.3K — 0.0% New 52
ExodusPoint Capital Management 3 26.6K 0 +26.6K — 0.0% New 52
Boothbay Fund Management 4 0 213.8K -213.8K -100.0% 0.0% Sold Out 51
J. Goldman & Co. 3 67.5K 0 +67.5K — 0.0% New 50
Centiva Capital 4 0 30.2K -30.2K -100.0% 0.0% Sold Out 48
Y-Intercept 4 10.4K 0 +10.4K — 0.0% New 48
Affinity Asset Advisors 2 312.5K 500.0K -187.5K -37.5% 0.2% Reduced 36
MILLENNIUM MANAGEMENT LLC 2 305.7K 420.6K -114.9K -27.3% 0.0% Reduced 35
Engineers Gate 4 34.0K 112.4K -78.5K -69.8% 0.0% Reduced 34
ADAGE CAPITAL PARTNERS GP, L.L.C. 2 1.5M 1.8M -285.0K -15.8% 0.0% Reduced 31
Brevan Howard Capital Management 3 309.8K 212.4K +97.5K +45.9% 0.1% Increased 30
RENAISSANCE TECHNOLOGIES LLC 1 108.2K 105.4K +2.8K +2.7% 0.0% Increased 28
Trexquant Investment 3 188.4K 257.9K -69.5K -27.0% 0.0% Reduced 26
RA Capital Management 1 1.9M 1.9M 0 +0.0% 0.2% Unchanged 26
Soleus Capital Management 2 440.0K 440.0K 0 +0.0% 0.1% Unchanged 21
Davidson Kempner Capital Management 2 300.0K 300.0K 0 +0.0% 0.1% Unchanged 20
MARSHALL WACE, LLP 2 128.5K 128.5K 0 +0.0% 0.0% Unchanged 20

Every fund above opens. Subscribers can see any manager's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.

Sign in or subscribe

Hedge funds are identified from their 13F filings, which are due 45 days after quarter end and cover long U.S.-listed equity positions only. A fund's short book never appears, so a reduced position can mean a changed view or a changed hedge — the filing doesn't say which.