SEPN Septerna, Inc.
Septerna, Inc. (SEPN) Institutional Ownership
What the institutions did with SEPN last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 7.0M | 14.7% |
| TRV GP V, LLC | 6.2M | 13.1% |
| Driehaus Capital Management LLC | 4.4M | 9.3% |
| TRV GP VI, LLC | 4.2M | 8.9% |
| SAMSARA BIOCAPITAL, LLC | 3.1M | 6.6% |
| GOLDMAN SACHS GROUP INC | 3.1M | 6.5% |
| BlackRock, Inc. | 1.9M | 4.1% |
| Siren, L.L.C. | 1.9M | 4.0% |
| Avoro Capital Advisors LLC | 1.3M | 2.8% |
| Jupiter Topco LLC | 1.3M | 2.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | 2.6% |
| PRIMECAP MANAGEMENT CO/CA/ | 1.2M | 2.5% |
| First Light Asset Management, LLC | 963.3K | 2.0% |
| ADAR1 Capital Management, LLC | 940.7K | 2.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 679.2K | 1.4% |
| STATE STREET CORP | 652.6K | 1.4% |
| LOOMIS SAYLES & CO L P | 624.8K | 1.3% |
| Casdin Capital, LLC | 553.3K | 1.2% |
| Catalio Capital Management, LP | 536.2K | 1.1% |
| ALGERT GLOBAL LLC | 397.5K | 0.8% |
| Kalehua Capital Management LLC | 389.1K | 0.8% |
| Balyasny Asset Management L.P. | 350.4K | 0.7% |
| Longaeva Partners L.P. | 298.2K | 0.6% |
| Soleus Capital Management, L.P. | 275.0K | 0.6% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 230.2K | 0.5% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| BVF INC/IL | Sold Out | 1.4M | 0 | -1.4M |
| LOOMIS SAYLES & CO L P | New | 0 | 624.8K | +624.8K |
| Venrock Adviser, LLC | Sold Out | 506.1K | 0 | -506.1K |
| ALGERT GLOBAL LLC | Increased | 21.0K | 397.5K | +376.5K |
| Catalio Capital Management, LP | Increased | 294.4K | 536.2K | +241.8K |
| First Light Asset Management, LLC | Increased | 732.9K | 963.3K | +230.4K |
| Longaeva Partners L.P. | Increased | 74.6K | 298.2K | +223.6K |
| Woodline Partners LP | New | 0 | 185.5K | +185.5K |
| GOLDMAN SACHS GROUP INC | Increased | 2.9M | 3.1M | +156.3K |
| ADAR1 Capital Management, LLC | Reduced | 1.1M | 940.7K | -149.1K |
| TWO SIGMA INVESTMENTS, LP | Increased | 75.4K | 220.9K | +145.5K |
| PRIMECAP MANAGEMENT CO/CA/ | Increased | 1.0M | 1.2M | +118.5K |
| Balyasny Asset Management L.P. | Increased | 236.7K | 350.4K | +113.8K |
| BlackRock, Inc. | Increased | 1.8M | 1.9M | +109.9K |
| Checkpoint Capital L.P. | Sold Out | 100.3K | 0 | -100.3K |
| Siren, L.L.C. | Reduced | 2.0M | 1.9M | -100.0K |
| LAZARD ASSET MANAGEMENT LLC | New | 0 | 75.4K | +75.4K |
| DIMENSIONAL FUND ADVISORS LP | New | 0 | 75.3K | +75.3K |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | 0 | 74.6K | +74.6K |
| MILLENNIUM MANAGEMENT LLC | Reduced | 124.1K | 50.6K | -73.5K |
| Invesco Ltd. | Reduced | 82.9K | 24.1K | -58.8K |
| Elmind Capital, LP | New | 0 | 49.4K | +49.4K |
| D. E. Shaw & Co., Inc. | New | 0 | 46.5K | +46.5K |
| JANE STREET GROUP, LLC | New | 0 | 45.6K | +45.6K |
| Voleon Capital Management LP | New | 0 | 44.4K | +44.4K |
| HRT FINANCIAL LP | New | 0 | 42.0K | +42.0K |
| HUSSMAN STRATEGIC ADVISORS, INC. | Reduced | 105.0K | 63.0K | -42.0K |
| MARSHALL WACE, LLP | Sold Out | 39.8K | 0 | -39.8K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Increased | 28.4K | 68.2K | +39.7K |
| Caption Management, LLC | New | 0 | 38.0K | +38.0K |
| Driehaus Capital Management LLC | Increased | 4.4M | 4.4M | +37.5K |
| NORTHERN TRUST CORP | Increased | 164.5K | 201.1K | +36.6K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 195.0K | 230.2K | +35.1K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 645.1K | 679.2K | +34.0K |
| Jump Financial, LLC | Reduced | 53.0K | 20.2K | -32.8K |
| Rangeley Capital, LLC | Reduced | 39.8K | 7.2K | -32.6K |
| Brevan Howard Capital Management LP | New | 0 | 29.5K | +29.5K |
| HighVista Strategies LLC | New | 0 | 29.3K | +29.3K |
| TUDOR INVESTMENT CORP ET AL | New | 0 | 29.0K | +29.0K |
| Russell Investments Group, Ltd. | Increased | 11.5K | 40.2K | +28.7K |
| BARCLAYS PLC | Increased | 22.7K | 49.8K | +27.1K |
| UBS Group AG | Reduced | 117.0K | 89.9K | -27.1K |
| Y-Intercept (Hong Kong) Ltd | Sold Out | 25.8K | 0 | -25.8K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 1.2M | 1.2M | +24.7K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold Out | 24.0K | 0 | -24.0K |
| MORGAN STANLEY | Increased | 110.5K | 134.4K | +23.8K |
| FOX RUN MANAGEMENT, L.L.C. | New | 0 | 22.0K | +22.0K |
| STATE STREET CORP | Increased | 631.4K | 652.6K | +21.2K |
| FRED ALGER MANAGEMENT, LLC | New | 0 | 21.0K | +21.0K |
| Nuveen, LLC | Increased | 29.2K | 48.2K | +19.1K |
| FRANKLIN RESOURCES INC | New | 0 | 18.6K | +18.6K |
| XTX Topco Ltd | Increased | 36.7K | 54.5K | +17.8K |
| Aquatic Capital Management LLC | New | 0 | 17.4K | +17.4K |
| VARCOV Co. | Sold Out | 16.8K | 0 | -16.8K |
| State of Wyoming | New | 0 | 16.4K | +16.4K |
| Numerai GP LLC | Sold Out | 15.1K | 0 | -15.1K |
| Verdad Advisers, LP | New | 0 | 13.0K | +13.0K |
| EntryPoint Capital, LLC | Sold Out | 12.8K | 0 | -12.8K |
| Verition Fund Management LLC | Sold Out | 12.3K | 0 | -12.3K |
| BNP PARIBAS FINANCIAL MARKETS | Increased | 5.4K | 16.9K | +11.6K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.