SEPN Septerna, Inc.

NASDAQ
$47.35

Septerna, Inc. (SEPN) Institutional Ownership

What the institutions did with SEPN last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended September 30, 2026.

Managers compared
38
filed both this quarter and last
Managers holding
37
+6 on the quarter
Buyers
24
7 opened new
Sellers
6
1 sold out entirely
Buyer share
80.0%
of managers who traded it
Breadth
+60.0
net buyers, as a share of those trading

Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.

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Ownership map

Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.

Cut Unchanged Added Color saturates at ±50%.

Largest holders

Manager Shares % of reported
DIMENSIONAL FUND ADVISORS LP 107.4K 25.2%
HUSSMAN STRATEGIC ADVISORS, INC. 63.0K 14.8%
Bank of New York Mellon Corp 58.0K 13.6%
BARCLAYS PLC 49.6K 11.6%
PROFUND ADVISORS LLC 38.3K 9.0%
STRS OHIO 27.2K 6.4%
VIRGINIA RETIREMENT SYSTEMS ET Al 16.6K 3.9%
CITIGROUP INC 13.5K 3.2%
China Universal Asset Management Co., Ltd. 12.1K 2.8%
Creative Planning 7.8K 1.8%
Prospera Financial Services Inc 6.2K 1.4%
State of New Jersey Common Pension Fund D 5.5K 1.3%
Chung Wu Investment Group, LLC 4.5K 1.1%
State of Wyoming 4.3K 1.0%
Covestor Ltd 2.5K 0.6%
Mirae Asset Global Investments Co., Ltd. 2.4K 0.6%
NEW YORK STATE TEACHERS RETIREMENT SYSTEM 1.9K 0.5%
GAMMA Investing LLC 1.4K 0.3%
GF FUND MANAGEMENT CO. LTD. 1.0K 0.2%
NISA INVESTMENT ADVISORS, LLC 829 0.2%
Sterling Capital Management LLC 630 0.1%
Pinnacle Wealth Planning Services, Inc. 322 0.1%
Versant Capital Management, Inc 261 0.1%
US BANCORP \DE\ 230 0.1%
Larson Financial Group LLC 205 0.0%

Largest changes

Manager Action Previous Current Change
PROFUND ADVISORS LLC New 0 38.3K +38.3K
DIMENSIONAL FUND ADVISORS LP Increased 75.3K 107.4K +32.1K
State of Wyoming Reduced 16.4K 4.3K -12.1K
STRS OHIO Increased 21.0K 27.2K +6.2K
Prospera Financial Services Inc New 0 6.2K +6.2K
State of New Jersey Common Pension Fund D New 0 5.5K +5.5K
CITIGROUP INC Reduced 17.8K 13.5K -4.3K
VIRGINIA RETIREMENT SYSTEMS ET Al Increased 13.3K 16.6K +3.3K
Bank of New York Mellon Corp Increased 56.2K 58.0K +1.8K
China Universal Asset Management Co., Ltd. Increased 10.8K 12.1K +1.3K
SIGNATUREFD, LLC Reduced 966 141 -825
Sterling Capital Management LLC Increased 200 630 +430
Covestor Ltd Increased 2.1K 2.5K +403
Mirae Asset Global Investments Co., Ltd. Increased 2.0K 2.4K +369
Chung Wu Investment Group, LLC Reduced 4.8K 4.5K -300
GAMMA Investing LLC Increased 1.1K 1.4K +259
BARCLAYS PLC Reduced 49.8K 49.6K -207
Creative Planning Increased 7.6K 7.8K +136
GF FUND MANAGEMENT CO. LTD. Increased 950 1.0K +83
Caitong International Asset Management Co., Ltd Sold Out 77 0 -77
NISA INVESTMENT ADVISORS, LLC Increased 768 829 +61
PNC Financial Services Group, Inc. Increased 45 86 +41
FINANCIAL CONSULATE, INC New 0 22 +22
US BANCORP \DE\ Increased 220 230 +10
Parkside Financial Bank & Trust New 0 10 +10
Larson Financial Group LLC Increased 196 205 +9
Silver Grove Financial Group, Inc. Increased 1 5 +4
Root Financial Partners, LLC New 0 3 +3
Farther Finance Advisors, LLC New 0 2 +2
SJS Investment Consulting Inc. Increased 6 8 +2

13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.