SEPN Septerna, Inc.
Septerna, Inc. (SEPN) Hedge Fund Activity
This view isolates hedge funds from the broader institutional ownership shown on the Institutional tab. A pension fund tracking an index may have no view on a stock; when a hedge fund builds or exits a position, that decision can carry information. This page measures those changes. Positions as of June 30, 2026.
Based on quarterly 13F long-equity filings. Changes compare reported quarter-end positions; filings can be reported up to 45 days later and do not represent a fund's complete exposure.
Most significant moves
Ranked by conviction, not size — how much of the fund's own book the position represents, how far it moved, and what kind of fund made it.
| Fund | Action | Shares changed | Change | Est. value | Portfolio wt. | Score |
|---|---|---|---|---|---|---|
| Biotechnology Value Fund Value Healthcare | Sold Out | -1.35M | -100.0% | $45.3M | 0.0% | 67 |
| D. E. Shaw & Co., Inc. Quant | New | +46.5K | — | $1.6M | 0.0% | 60 |
| MARSHALL WACE, LLP Long/Short | Sold Out | -39.8K | -100.0% | $1.3M | 0.0% | 58 |
| CITADEL ADVISORS LLC Quant | New | +6.4K | — | $212.7K | 0.0% | 58 |
| Woodline Partners LP Long/Short | New | +185.5K | — | $6.2M | 0.0% | 56 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold Out | -24.0K | -100.0% | $803.8K | 0.0% | 56 |
| Gotham Asset Management, LLC Quant Value | New | +9.3K | — | $312.2K | 0.0% | 54 |
| Verition Fund Management Event Long/Short | Sold Out | -12.3K | -100.0% | $413.4K | 0.0% | 54 |
| Tudor Investment Corporation Macro | New | +29.0K | — | $970.1K | 0.0% | 54 |
| Voleon Capital Management Quant | New | +44.4K | — | $1.5M | 0.0% | 53 |
Most significant buyers
By move score, not size.
- D. E. Shaw & Co., Inc.
- CITADEL ADVISORS LLC
- Woodline Partners LP
- Gotham Asset Management, LLC
- Tudor Investment Corporation
Most significant sellers
By move score, not size.
- Biotechnology Value Fund
- MARSHALL WACE, LLP
- ADAGE CAPITAL PARTNERS GP, L.L.C.
- Verition Fund Management
- Y-Intercept
Hedge fund positions
| Fund | Tier | Shares | Previous | Change | Change % | Portfolio wt. | Action | Score |
|---|---|---|---|---|---|---|---|---|
| Biotechnology Value Fund | 1 | 0 | 1.4M | -1.35M | -100.0% | 0.0% | Sold Out | 67 |
| D. E. Shaw & Co., Inc. | 1 | 46.5K | 0 | +46.5K | — | 0.0% | New | 60 |
| MARSHALL WACE, LLP | 2 | 0 | 39.8K | -39.8K | -100.0% | 0.0% | Sold Out | 58 |
| CITADEL ADVISORS LLC | 1 | 6.4K | 0 | +6.4K | — | 0.0% | New | 58 |
| Woodline Partners LP | 2 | 185.5K | 0 | +185.5K | — | 0.0% | New | 56 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2 | 0 | 24.0K | -24.0K | -100.0% | 0.0% | Sold Out | 56 |
| Gotham Asset Management, LLC | 2 | 9.3K | 0 | +9.3K | — | 0.0% | New | 54 |
| Verition Fund Management | 2 | 0 | 12.3K | -12.3K | -100.0% | 0.0% | Sold Out | 54 |
| Tudor Investment Corporation | 2 | 29.0K | 0 | +29.0K | — | 0.0% | New | 54 |
| Voleon Capital Management | 3 | 44.4K | 0 | +44.4K | — | 0.0% | New | 53 |
| TWO SIGMA INVESTMENTS, LP | 2 | 220.9K | 75.4K | +145.5K | +193.1% | 0.0% | Increased | 53 |
| Caption Management | 3 | 38.0K | 0 | +38.0K | — | 0.0% | New | 52 |
| Brevan Howard Capital Management | 3 | 29.5K | 0 | +29.5K | — | 0.0% | New | 49 |
| Y-Intercept | 4 | 0 | 25.8K | -25.8K | -100.0% | 0.0% | Sold Out | 48 |
| Aquatic Capital Management | 4 | 17.4K | 0 | +17.4K | — | 0.0% | New | 48 |
| Quantbot Technologies | 4 | 515 | 0 | +515 | — | 0.0% | New | 45 |
| MILLENNIUM MANAGEMENT LLC | 2 | 50.6K | 124.1K | -73.5K | -59.3% | 0.0% | Reduced | 43 |
| Balyasny Asset Management L.P. | 2 | 350.4K | 236.7K | +113.8K | +48.1% | 0.0% | Increased | 40 |
| ADAR1 Capital Management | 3 | 940.7K | 1.1M | -149.1K | -13.7% | 1.6% | Reduced | 36 |
| RENAISSANCE TECHNOLOGIES LLC | 1 | 41.4K | 37.7K | +3.7K | +9.9% | 0.0% | Increased | 30 |
| Squarepoint Ops LLC | 2 | 21.2K | 18.1K | +3.1K | +17.3% | 0.0% | Increased | 28 |
| Trexquant Investment | 3 | 25.6K | 35.3K | -9.7K | -27.4% | 0.0% | Reduced | 27 |
| Winton Group | 4 | 7.2K | 8.8K | -1.7K | -18.8% | 0.0% | Reduced | 22 |
| Man Group | 3 | 11.5K | 11.9K | -389 | -3.3% | 0.0% | Reduced | 22 |
| AQR Capital Management | 3 | 15.4K | 15.4K | +22 | +0.1% | 0.0% | Increased | 20 |
| Engineers Gate | 4 | 17.4K | 16.5K | +822 | +5.0% | 0.0% | Increased | 18 |
| RA Capital Management | 1 | 7.0M | 7.0M | 0 | +0.0% | 2.0% | Unchanged | 35 |
| Avoro Capital Advisors | 1 | 1.3M | 1.3M | 0 | +0.0% | 0.4% | Unchanged | 26 |
| Soleus Capital Management | 2 | 275.0K | 275.0K | 0 | +0.0% | 0.3% | Unchanged | 22 |
| Alyeska Investment Group, L.P. | 2 | 35.0K | 35.0K | 0 | +0.0% | 0.0% | Unchanged | 20 |
| Logos Global Management | 2 | 23.5K | 23.5K | 0 | +0.0% | 0.0% | Unchanged | 20 |
Every fund above opens. Subscribers can see any manager's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
Sign in or subscribeHedge funds are identified from their 13F filings, which are due 45 days after quarter end and cover long U.S.-listed equity positions only. A fund's short book never appears, so a reduced position can mean a changed view or a changed hedge — the filing doesn't say which.