SYRE Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. (SYRE) Institutional Ownership
What the institutions did with SYRE last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 13.0M | 13.6% |
| BlackRock, Inc. | 6.5M | 6.8% |
| PERCEPTIVE ADVISORS LLC | 4.3M | 4.5% |
| RTW INVESTMENTS, LP | 4.3M | 4.4% |
| Paradigm Biocapital Advisors LP | 3.8M | 4.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.4M | 3.6% |
| STATE STREET CORP | 3.1M | 3.2% |
| Venrock Adviser, LLC | 3.0M | 3.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.0M | 3.1% |
| Driehaus Capital Management LLC | 2.8M | 2.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 2.6M | 2.7% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2.3M | 2.4% |
| Capital World Investors | 2.3M | 2.4% |
| Jupiter Topco LLC | 2.2M | 2.3% |
| TCG Crossover Management, LLC | 1.9M | 2.0% |
| TANG CAPITAL MANAGEMENT LLC | 1.9M | 2.0% |
| BANK OF AMERICA CORP /DE/ | 1.8M | 1.9% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.7M | 1.8% |
| WELLINGTON MANAGEMENT GROUP LLP | 1.6M | 1.7% |
| GOLDMAN SACHS GROUP INC | 1.5M | 1.5% |
| FRANKLIN RESOURCES INC | 1.5M | 1.5% |
| Remedium Capital Partners, LLC | 1.5M | 1.5% |
| Affinity Asset Advisors, LLC | 1.3M | 1.3% |
| JPMORGAN CHASE & CO | 1.1M | 1.1% |
| Holocene Advisors, LP | 1.0M | 1.1% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| Fairmount Funds Management LLC | Sold Out | 4.0M | 0 | -4.0M |
| Paradigm Biocapital Advisors LP | Increased | 2.0M | 3.8M | +1.9M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 585.1K | 2.3M | +1.7M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | 0 | 1.7M | +1.7M |
| Capital World Investors | Increased | 666.6K | 2.3M | +1.6M |
| RA CAPITAL MANAGEMENT, L.P. | Sold Out | 1.6M | 0 | -1.6M |
| PRICE T ROWE ASSOCIATES INC /MD/ | Increased | 1.6M | 3.0M | +1.4M |
| FMR LLC | Increased | 11.8M | 13.0M | +1.2M |
| GOLDMAN SACHS GROUP INC | Increased | 269.9K | 1.5M | +1.2M |
| Commodore Capital LP | Reduced | 1.9M | 846.8K | -1.1M |
| Holocene Advisors, LP | New | 0 | 1.0M | +1.0M |
| BAKER BROS. ADVISORS LP | Sold Out | 1.0M | 0 | -1.0M |
| BlackRock, Inc. | Increased | 5.5M | 6.5M | +985.4K |
| Caligan Partners LP | Sold Out | 878.1K | 0 | -878.1K |
| MARSHALL WACE, LLP | Increased | 139.3K | 991.7K | +852.4K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 1.7M | 2.6M | +841.4K |
| Capital International Investors | Reduced | 1.7M | 955.2K | -790.9K |
| Venrock Adviser, LLC | Reduced | 3.7M | 3.0M | -700.0K |
| FRANKLIN RESOURCES INC | Increased | 882.8K | 1.5M | +590.1K |
| BANK OF AMERICA CORP /DE/ | Increased | 1.2M | 1.8M | +549.8K |
| PERCEPTIVE ADVISORS LLC | Increased | 3.8M | 4.3M | +536.3K |
| STATE STREET CORP | Increased | 2.6M | 3.1M | +450.4K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 3.1M | 3.4M | +391.3K |
| VOYA INVESTMENT MANAGEMENT LLC | Increased | 54.0K | 431.7K | +377.7K |
| Integral Health Asset Management, LLC | New | 0 | 325.0K | +325.0K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Increased | 207.3K | 522.1K | +314.8K |
| JENNISON ASSOCIATES LLC | New | 0 | 303.2K | +303.2K |
| VICTORY CAPITAL MANAGEMENT INC | Increased | 292.1K | 554.0K | +261.9K |
| MORGAN STANLEY | Increased | 246.7K | 500.0K | +253.2K |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | 1.8M | 1.6M | -243.3K |
| BNP PARIBAS FINANCIAL MARKETS | Increased | 18.6K | 259.9K | +241.3K |
| Bellevue Group AG | New | 0 | 229.9K | +229.9K |
| STEMPOINT CAPITAL LP | Reduced | 335.2K | 106.9K | -228.3K |
| Cormorant Asset Management, LP | New | 0 | 225.0K | +225.0K |
| EVENTIDE ASSET MANAGEMENT, LLC | New | 0 | 201.6K | +201.6K |
| AMERIPRISE FINANCIAL INC | Increased | 159.2K | 356.1K | +196.9K |
| Polar Capital Holdings Plc | Increased | 792.8K | 988.0K | +195.2K |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | 193.0K | 6.5K | -186.6K |
| ORBIMED ADVISORS LLC | New | 0 | 186.1K | +186.1K |
| FRONTIER CAPITAL MANAGEMENT CO LLC | New | 0 | 182.9K | +182.9K |
| NEUBERGER BERMAN GROUP LLC | New | 0 | 180.9K | +180.9K |
| Blackstone Inc. | Reduced | 292.8K | 120.2K | -172.7K |
| UBS Group AG | Increased | 671.2K | 843.1K | +171.8K |
| FIRST TRUST ADVISORS LP | Reduced | 178.4K | 9.8K | -168.6K |
| Siren, L.L.C. | Increased | 818.6K | 968.6K | +150.0K |
| Soleus Capital Management, L.P. | New | 0 | 147.0K | +147.0K |
| Squarepoint Ops LLC | New | 0 | 139.6K | +139.6K |
| Pictet Asset Management Holding SA | Increased | 491.6K | 628.1K | +136.5K |
| SILVERARC CAPITAL MANAGEMENT, LLC | Reduced | 186.6K | 60.0K | -126.7K |
| SEVEN GRAND MANAGERS, LLC | Increased | 100.0K | 225.0K | +125.0K |
| Russell Investments Group, Ltd. | Increased | 9.9K | 134.8K | +124.8K |
| Rhenman & Partners Asset Management AB | New | 0 | 119.3K | +119.3K |
| JPMORGAN CHASE & CO | Increased | 979.3K | 1.1M | +113.7K |
| Boxer Capital Management, LLC | New | 0 | 100.0K | +100.0K |
| NORTHERN TRUST CORP | Increased | 578.9K | 674.5K | +95.6K |
| Balyasny Asset Management L.P. | Increased | 55.5K | 147.0K | +91.6K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Increased | 562.7K | 653.0K | +90.3K |
| ExodusPoint Capital Management, LP | Sold Out | 87.1K | 0 | -87.1K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 464.7K | 551.4K | +86.7K |
| FEDERATED HERMES, INC. | New | 0 | 86.0K | +86.0K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.