SYRE Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. (SYRE) Institutional Ownership
What the institutions did with SYRE last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
Sign in or subscribeLargest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 13.0M | 12.8% |
| BlackRock, Inc. | 6.5M | 6.4% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5.7M | 5.7% |
| PERCEPTIVE ADVISORS LLC | 4.3M | 4.3% |
| RTW INVESTMENTS, LP | 4.3M | 4.2% |
| Paradigm Biocapital Advisors LP | 3.8M | 3.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.4M | 3.4% |
| STATE STREET CORP | 3.1M | 3.0% |
| Venrock Adviser, LLC | 3.0M | 2.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.0M | 2.9% |
| Driehaus Capital Management LLC | 2.8M | 2.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 2.6M | 2.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2.3M | 2.3% |
| Capital World Investors | 2.3M | 2.3% |
| Jupiter Topco LLC | 2.2M | 2.2% |
| TCG Crossover Management, LLC | 1.9M | 1.9% |
| TANG CAPITAL MANAGEMENT LLC | 1.9M | 1.9% |
| BANK OF AMERICA CORP /DE/ | 1.8M | 1.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.7M | 1.7% |
| WELLINGTON MANAGEMENT GROUP LLP | 1.6M | 1.6% |
| GOLDMAN SACHS GROUP INC | 1.5M | 1.5% |
| FRANKLIN RESOURCES INC | 1.5M | 1.5% |
| Remedium Capital Partners, LLC | 1.5M | 1.4% |
| Affinity Asset Advisors, LLC | 1.3M | 1.3% |
| JPMORGAN CHASE & CO | 1.1M | 1.1% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | Increased | 59.2K | 5.7M | +5.7M |
| Fairmount Funds Management LLC | Sold Out | 4.0M | 0 | -4.0M |
| Paradigm Biocapital Advisors LP | Increased | 2.0M | 3.8M | +1.9M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 585.1K | 2.3M | +1.7M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | 0 | 1.7M | +1.7M |
| Capital World Investors | Increased | 666.6K | 2.3M | +1.6M |
| RA CAPITAL MANAGEMENT, L.P. | Sold Out | 1.6M | 0 | -1.6M |
| PRICE T ROWE ASSOCIATES INC /MD/ | Increased | 1.6M | 3.0M | +1.4M |
| FMR LLC | Increased | 11.8M | 13.0M | +1.2M |
| GOLDMAN SACHS GROUP INC | Increased | 269.9K | 1.5M | +1.2M |
| Commodore Capital LP | Reduced | 1.9M | 846.8K | -1.1M |
| Holocene Advisors, LP | New | 0 | 1.0M | +1.0M |
| BAKER BROS. ADVISORS LP | Sold Out | 1.0M | 0 | -1.0M |
| BlackRock, Inc. | Increased | 5.5M | 6.5M | +985.4K |
| Caligan Partners LP | Sold Out | 878.1K | 0 | -878.1K |
| MARSHALL WACE, LLP | Increased | 139.3K | 991.7K | +852.4K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 1.7M | 2.6M | +841.4K |
| Capital International Investors | Reduced | 1.7M | 955.2K | -790.9K |
| Venrock Adviser, LLC | Reduced | 3.7M | 3.0M | -700.0K |
| FRANKLIN RESOURCES INC | Increased | 882.8K | 1.5M | +590.1K |
| BANK OF AMERICA CORP /DE/ | Increased | 1.2M | 1.8M | +549.8K |
| PERCEPTIVE ADVISORS LLC | Increased | 3.8M | 4.3M | +536.3K |
| STATE STREET CORP | Increased | 2.6M | 3.1M | +450.4K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 3.1M | 3.4M | +391.3K |
| VOYA INVESTMENT MANAGEMENT LLC | Increased | 54.0K | 431.7K | +377.7K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.