SYRE Spyre Therapeutics, Inc.

NASDAQ
$90.95

Spyre Therapeutics, Inc. (SYRE) Hedge Fund Activity

This view isolates hedge funds from the broader institutional ownership shown on the Institutional tab. A pension fund tracking an index may have no view on a stock; when a hedge fund builds or exits a position, that decision can carry information. This page measures those changes. Positions as of June 30, 2026.

Based on quarterly 13F long-equity filings. Changes compare reported quarter-end positions; filings can be reported up to 45 days later and do not represent a fund's complete exposure.

Hedge fund breadth
+45.00
29 buyers / 11 sellers
STRONG BUYING
Funds compared
42
funds with comparable SYRE positions
37 current holders · 25 prior-quarter holders
Net share change
+3.58M
+7.49M added, -3.90M cut
Position activity
17 new 12 increased 6 reduced 5 exited

Most significant moves

Ranked by conviction, not size — how much of the fund's own book the position represents, how far it moved, and what kind of fund made it.

Fund Action Shares changed Change Est. value Portfolio wt. Score
Paradigm BioCapital Advisors Growth Healthcare Increased +1.88M +96.2% $167.2M 6.4% 85
Caligan Partners Activist Event Sold Out -878.1K -100.0% $78.0M 0.0% 84
RA Capital Management Growth Healthcare Sold Out -1.62M -100.0% $144.0M 0.0% 73
Baker Bros. Advisors Growth Healthcare Sold Out -1.00M -100.0% $88.8M 0.0% 68
Integral Health Asset Management Growth Healthcare New +325.0K — $28.9M 1.2% 66
ADAGE CAPITAL PARTNERS GP, L.L.C. New +1.72M — $152.9M 0.2% 65
Soleus Capital Management Growth Healthcare New +147.0K — $13.1M 0.5% 63
Holocene Advisors, LP New +1.02M — $90.1M 0.2% 63
OrbiMed Advisors Growth Healthcare New +186.1K — $16.5M 0.3% 63
Perceptive Advisors Growth Healthcare Increased +536.3K +14.2% $47.6M 6.0% 62

Most significant buyers

By move score, not size.

  • Paradigm BioCapital Advisors Increased · +1.88M
  • Integral Health Asset Management New · +325.0K
  • ADAGE CAPITAL PARTNERS GP, L.L.C. New · +1.72M
  • Soleus Capital Management New · +147.0K
  • Holocene Advisors, LP New · +1.02M

Most significant sellers

By move score, not size.

  • Caligan Partners Sold Out · -878.1K
  • RA Capital Management Sold Out · -1.62M
  • Baker Bros. Advisors Sold Out · -1.00M
  • ExodusPoint Capital Management Sold Out · -87.1K
  • Capstone Investment Advisors Sold Out · -7.5K

Hedge fund positions

Fund Tier Shares Previous Change Change % Portfolio wt. Action Score
Paradigm BioCapital Advisors 1 3.8M 2.0M +1.88M +96.2% 6.4% Increased 85
Caligan Partners 2 0 878.1K -878.1K -100.0% 0.0% Sold Out 84
RA Capital Management 1 0 1.6M -1.62M -100.0% 0.0% Sold Out 73
Baker Bros. Advisors 1 0 1.0M -1.00M -100.0% 0.0% Sold Out 68
Integral Health Asset Management 2 325.0K 0 +325.0K — 1.2% New 66
ADAGE CAPITAL PARTNERS GP, L.L.C. 2 1.7M 0 +1.72M — 0.2% New 65
Soleus Capital Management 2 147.0K 0 +147.0K — 0.5% New 63
Holocene Advisors, LP 2 1.0M 0 +1.02M — 0.2% New 63
OrbiMed Advisors 2 186.1K 0 +186.1K — 0.3% New 63
Perceptive Advisors 1 4.3M 3.8M +536.3K +14.2% 6.0% Increased 62
D. E. Shaw & Co., Inc. 1 26.5K 0 +26.5K — 0.0% New 60
TWO SIGMA INVESTMENTS, LP 2 12.8K 0 +12.8K — 0.0% New 59
Squarepoint Ops LLC 2 139.6K 0 +139.6K — 0.0% New 59
Ghisallo Capital Management 2 30.0K 0 +30.0K — 0.1% New 57
MARSHALL WACE, LLP 2 991.7K 139.3K +852.4K +612.1% 0.1% Increased 57
Rock Springs Capital Management 3 42.3K 0 +42.3K — 0.2% New 56
Hudson Bay Capital Management 3 58.4K 0 +58.4K — 0.0% New 55
ExodusPoint Capital Management 3 0 87.1K -87.1K -100.0% 0.0% Sold Out 54
Balyasny Asset Management L.P. 2 147.0K 55.5K +91.6K +165.1% 0.0% Increased 53
Schonfeld Strategic Advisors 3 19.1K 0 +19.1K — 0.0% New 53
Trexquant Investment 3 67.0K 0 +67.0K — 0.0% New 53
Capstone Investment Advisors 3 0 7.5K -7.5K -100.0% 0.0% Sold Out 53
Caption Management 3 36.0K 0 +36.0K — 0.1% New 53
Aquatic Capital Management 4 25.2K 0 +25.2K — 0.1% New 50
Engineers Gate 4 38.5K 0 +38.5K — 0.0% New 50
Brevan Howard Capital Management 3 8.3K 0 +8.3K — 0.0% New 49
RTW Investments 1 4.3M 4.2M +80.0K +1.9% 3.2% Increased 49
Boothbay Fund Management 4 6.5K 193.0K -186.6K -96.7% 0.0% Reduced 47
Braidwell 2 879.5K 932.8K -53.4K -5.7% 3.0% Reduced 44
Cinctive Capital Management 3 49.0K 27.4K +21.5K +78.6% 0.2% Increased 41
Tudor Investment Corporation 2 2.6K 8.4K -5.7K -68.4% 0.0% Reduced 40
Quantbot Technologies 4 8.9K 88 +8.8K +9995.5% 0.0% Increased 39
MILLENNIUM MANAGEMENT LLC 2 196.7K 146.6K +50.1K +34.1% 0.0% Increased 37
ADAR1 Capital Management 3 284.0K 338.3K -54.3K -16.1% 1.3% Reduced 34
Samlyn Capital 2 400.1K 396.7K +3.4K +0.9% 0.6% Increased 30
Woodline Partners LP 2 306.0K 265.9K +40.2K +15.1% 0.1% Increased 29
Armistice Capital 3 137.6K 120.9K +16.7K +13.8% 0.3% Increased 29
CITADEL ADVISORS LLC 1 103.1K 108.1K -5.0K -4.7% 0.0% Reduced 28
Man Group 3 7.7K 9.5K -1.8K -19.2% 0.0% Reduced 26
AQR Capital Management 3 22.9K 20.9K +2.1K +9.9% 0.0% Increased 22
Tang Capital Management 2 1.9M 1.9M 0 +0.0% 7.7% Unchanged 44
Affinity Asset Advisors 2 1.3M 1.3M 0 +0.0% 5.7% Unchanged 44

Every fund above opens. Subscribers can see any manager's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.

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Hedge funds are identified from their 13F filings, which are due 45 days after quarter end and cover long U.S.-listed equity positions only. A fund's short book never appears, so a reduced position can mean a changed view or a changed hedge — the filing doesn't say which.