TSHA Taysha Gene Therapies, Inc.
Taysha Gene Therapies, Inc. (TSHA) Institutional Ownership
What the institutions did with TSHA last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| Avoro Capital Advisors LLC | 23.9M | 8.0% |
| RA CAPITAL MANAGEMENT, L.P. | 23.6M | 7.9% |
| GOLDMAN SACHS GROUP INC | 22.7M | 7.6% |
| BlackRock, Inc. | 20.7M | 6.9% |
| Vestal Point Capital, LP | 19.4M | 6.5% |
| MORGAN STANLEY | 16.5M | 5.5% |
| RTW INVESTMENTS, LP | 13.6M | 4.5% |
| FMR LLC | 13.3M | 4.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 12.5M | 4.2% |
| STATE STREET CORP | 11.4M | 3.8% |
| Siren, L.L.C. | 9.8M | 3.3% |
| Octagon Capital Advisors LP | 9.7M | 3.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 6.6M | 2.2% |
| Polar Capital Holdings Plc | 5.1M | 1.7% |
| MPM BIOIMPACT LLC | 4.5M | 1.5% |
| D. E. Shaw & Co., Inc. | 4.4M | 1.5% |
| BAKER BROS. ADVISORS LP | 4.0M | 1.3% |
| WELLINGTON MANAGEMENT GROUP LLP | 4.0M | 1.3% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 3.9M | 1.3% |
| Casdin Capital, LLC | 3.3M | 1.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3.1M | 1.0% |
| ADAR1 Capital Management, LLC | 3.0M | 1.0% |
| Pictet Asset Management Holding SA | 2.8M | 0.9% |
| Aberdeen Group plc | 2.3M | 0.8% |
| FARALLON CAPITAL MANAGEMENT LLC | 2.3M | 0.8% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| MPM BIOIMPACT LLC | New | 0 | 4.5M | +4.5M |
| WELLINGTON MANAGEMENT GROUP LLP | Increased | 626.4K | 4.0M | +3.3M |
| Pictet Asset Management Holding SA | Increased | 19.3K | 2.8M | +2.8M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Sold Out | 2.7M | 0 | -2.7M |
| BlackRock, Inc. | Increased | 18.4M | 20.7M | +2.3M |
| FARALLON CAPITAL MANAGEMENT LLC | New | 0 | 2.3M | +2.3M |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 10.2M | 12.5M | +2.2M |
| Avoro Capital Advisors LLC | Increased | 21.7M | 23.9M | +2.2M |
| ORBIMED ADVISORS LLC | New | 0 | 2.0M | +2.0M |
| SG Americas Securities, LLC | Reduced | 2.2M | 202.3K | -2.0M |
| HEIGHTS CAPITAL MANAGEMENT, INC | New | 0 | 1.5M | +1.5M |
| MORGAN STANLEY | Reduced | 18.0M | 16.5M | -1.5M |
| Vestal Point Capital, LP | Increased | 18.0M | 19.4M | +1.4M |
| Aberdeen Group plc | Increased | 1.0M | 2.3M | +1.3M |
| BARCLAYS PLC | Reduced | 2.8M | 1.6M | -1.2M |
| MILLENNIUM MANAGEMENT LLC | Reduced | 3.3M | 2.1M | -1.2M |
| CITADEL ADVISORS LLC | Increased | 411.1K | 1.5M | +1.1M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 2.0M | 3.1M | +1.1M |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 5.5M | 6.6M | +1.0M |
| Siren, L.L.C. | Increased | 8.8M | 9.8M | +1.0M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Increased | 2.9M | 3.9M | +1.0M |
| FMR LLC | Reduced | 14.3M | 13.3M | -984.8K |
| Seven Fleet Capital Management LP | Increased | 625.7K | 1.5M | +878.7K |
| Octagon Capital Advisors LP | Increased | 8.9M | 9.7M | +833.3K |
| FIRST TRUST ADVISORS LP | New | 0 | 791.2K | +791.2K |
| Affinity Asset Advisors, LLC | Increased | 1.0M | 1.8M | +750.0K |
| AFFINITY WEALTH MANAGEMENT LLC | New | 0 | 576.8K | +576.8K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | 0 | 553.0K | +553.0K |
| Polar Capital Holdings Plc | Reduced | 5.7M | 5.1M | -537.2K |
| DIADEMA PARTNERS LP | New | 0 | 522.6K | +522.6K |
| BNP PARIBAS FINANCIAL MARKETS | Increased | 120.2K | 640.0K | +519.8K |
| Holocene Advisors, LP | New | 0 | 510.0K | +510.0K |
| TWO SIGMA INVESTMENTS, LP | Reduced | 742.1K | 234.7K | -507.4K |
| Ghisallo Capital Management LLC | New | 0 | 505.0K | +505.0K |
| Burkehill Global Management, LP | New | 0 | 500.0K | +500.0K |
| Point72 Asset Management, L.P. | Sold Out | 461.9K | 0 | -461.9K |
| Granahan Investment Management, LLC | Increased | 883.2K | 1.3M | +421.9K |
| RENAISSANCE TECHNOLOGIES LLC | Sold Out | 413.2K | 0 | -413.2K |
| NORTHERN TRUST CORP | Increased | 1.8M | 2.2M | +411.9K |
| PANAGORA ASSET MANAGEMENT INC | Increased | 182.2K | 590.4K | +408.2K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Increased | 1.8M | 2.2M | +392.1K |
| Trexquant Investment LP | New | 0 | 379.6K | +379.6K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 1.5M | 1.9M | +366.0K |
| GOLDMAN SACHS GROUP INC | Increased | 22.4M | 22.7M | +343.5K |
| BANK OF AMERICA CORP /DE/ | Reduced | 1.7M | 1.4M | -304.2K |
| Qube Research & Technologies Ltd | New | 0 | 259.6K | +259.6K |
| SUPERSTRING CAPITAL MANAGEMENT LP | Sold Out | 258.3K | 0 | -258.3K |
| SPHERA FUNDS MANAGEMENT LTD. | New | 0 | 250.0K | +250.0K |
| CITIGROUP INC | Increased | 57.1K | 306.9K | +249.8K |
| JANE STREET GROUP, LLC | New | 0 | 228.4K | +228.4K |
| STATE STREET CORP | Increased | 11.2M | 11.4M | +212.8K |
| Monashee Investment Management LLC | New | 0 | 200.0K | +200.0K |
| POLEN CAPITAL MANAGEMENT LLC | Increased | 319.7K | 489.2K | +169.5K |
| Squarepoint Ops LLC | Increased | 410.3K | 569.3K | +159.0K |
| Jefferies Financial Group Inc. | Reduced | 479.0K | 328.8K | -150.2K |
| WELLS FARGO & COMPANY/MN | Increased | 183.3K | 333.3K | +150.0K |
| Rafferty Asset Management, LLC | Reduced | 299.9K | 154.7K | -145.2K |
| RAYMOND JAMES FINANCIAL INC | Increased | 22.0K | 166.0K | +144.0K |
| TUDOR INVESTMENT CORP ET AL | Sold Out | 143.6K | 0 | -143.6K |
| Persistent Asset Partners Ltd | New | 0 | 133.4K | +133.4K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.