TYRA Tyra Biosciences, Inc.
Tyra Biosciences, Inc. (TYRA) Institutional Ownership
What the institutions did with TYRA last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
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Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12.2M | 17.6% |
| FMR LLC | 8.9M | 12.9% |
| Jupiter Topco LLC | 4.4M | 6.3% |
| Alta Partners Management Company, L.P. | 3.8M | 5.5% |
| Nextech Invest, Ltd. | 3.6M | 5.1% |
| TCG Crossover Management, LLC | 3.2M | 4.7% |
| BlackRock, Inc. | 3.0M | 4.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.8M | 4.0% |
| STATE STREET CORP | 2.1M | 3.1% |
| Commodore Capital LP | 1.9M | 2.7% |
| Paradigm Biocapital Advisors LP | 1.8M | 2.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.5M | 2.2% |
| BVF INC/IL | 1.5M | 2.1% |
| 5AM Venture Management, LLC | 1.0M | 1.5% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.0M | 1.5% |
| Hood River Capital Management LLC | 1.0M | 1.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 970.7K | 1.4% |
| Caligan Partners LP | 807.0K | 1.2% |
| Canaan Partners XI LLC | 750.0K | 1.1% |
| Siren, L.L.C. | 725.0K | 1.0% |
| Sio Capital Management, LLC | 695.3K | 1.0% |
| STEMPOINT CAPITAL LP | 632.8K | 0.9% |
| MARSHALL WACE, LLP | 583.1K | 0.8% |
| GOLDMAN SACHS GROUP INC | 463.5K | 0.7% |
| JENNISON ASSOCIATES LLC | 451.0K | 0.6% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | Sold Out | 3.6M | 0 | -3.6M |
| PRICE T ROWE ASSOCIATES INC /MD/ | Increased | 986.1K | 2.8M | +1.8M |
| FMR LLC | Increased | 7.7M | 8.9M | +1.2M |
| Hood River Capital Management LLC | New | 0 | 1.0M | +1.0M |
| STATE STREET CORP | Increased | 1.2M | 2.1M | +924.3K |
| Logos Global Management LP | Sold Out | 850.0K | 0 | -850.0K |
| BlackRock, Inc. | Increased | 2.2M | 3.0M | +814.0K |
| BARCLAYS PLC | Reduced | 833.4K | 20.3K | -813.1K |
| Siren, L.L.C. | New | 0 | 725.0K | +725.0K |
| Commodore Capital LP | Reduced | 2.5M | 1.9M | -600.0K |
| Nextech Invest, Ltd. | Reduced | 4.1M | 3.6M | -502.3K |
| BVF INC/IL | Reduced | 2.0M | 1.5M | -500.0K |
| Caligan Partners LP | Reduced | 1.3M | 807.0K | -470.0K |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Increased | 549.0K | 1.0M | +468.0K |
| MARSHALL WACE, LLP | Increased | 197.7K | 583.1K | +385.4K |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 1.1M | 1.5M | +382.5K |
| Defilade Capital Management, L.P. | New | 0 | 376.9K | +376.9K |
| Balyasny Asset Management L.P. | Sold Out | 351.5K | 0 | -351.5K |
| TWO SIGMA INVESTMENTS, LP | Increased | 101.6K | 449.8K | +348.2K |
| Elmind Capital, LP | Reduced | 350.0K | 20.0K | -330.0K |
| Walleye Capital LLC | Increased | 18.7K | 347.9K | +329.2K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 658.5K | 970.7K | +312.3K |
| Qube Research & Technologies Ltd | New | 0 | 266.9K | +266.9K |
| CITADEL ADVISORS LLC | Increased | 15.4K | 278.3K | +262.9K |
| STEMPOINT CAPITAL LP | Increased | 386.4K | 632.8K | +246.4K |
| Paradigm Biocapital Advisors LP | Reduced | 2.1M | 1.8M | -226.4K |
| Seven Fleet Capital Management LP | Sold Out | 195.7K | 0 | -195.7K |
| JENNISON ASSOCIATES LLC | Reduced | 632.4K | 451.0K | -181.5K |
| MORGAN STANLEY | Increased | 120.5K | 300.3K | +179.8K |
| FRANKLIN RESOURCES INC | Increased | 13.0K | 192.3K | +179.4K |
| Sofinnova Investments, Inc. | Reduced | 204.0K | 32.3K | -171.7K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | 0 | 162.0K | +162.0K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 247.3K | 403.0K | +155.7K |
| BANK OF AMERICA CORP /DE/ | Increased | 209.9K | 349.7K | +139.8K |
| VICTORY CAPITAL MANAGEMENT INC | Increased | 15.2K | 152.6K | +137.4K |
| AMERIPRISE FINANCIAL INC | Reduced | 144.9K | 16.9K | -128.0K |
| DIMENSIONAL FUND ADVISORS LP | Increased | 91.8K | 217.1K | +125.3K |
| LORD, ABBETT & CO. LLC | New | 0 | 121.8K | +121.8K |
| Jump Financial, LLC | Increased | 41.4K | 157.0K | +115.6K |
| JPMORGAN CHASE & CO | Increased | 66.8K | 178.3K | +111.5K |
| ORBIMED ADVISORS LLC | New | 0 | 102.0K | +102.0K |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | 273.3K | 173.6K | -99.7K |
| NORTHERN TRUST CORP | Increased | 218.5K | 310.1K | +91.6K |
| Sio Capital Management, LLC | Increased | 605.4K | 695.3K | +89.9K |
| GOLDMAN SACHS GROUP INC | Reduced | 550.3K | 463.5K | -86.9K |
| Invesco Ltd. | Reduced | 109.1K | 24.9K | -84.2K |
| Schonfeld Strategic Advisors LLC | Sold Out | 79.6K | 0 | -79.6K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | 162.2K | 89.2K | -73.0K |
| Ensign Peak Advisors, Inc | Increased | 74.1K | 146.5K | +72.5K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Increased | 199.1K | 267.7K | +68.6K |
| UBS Group AG | Increased | 61.6K | 129.9K | +68.4K |
| Cinctive Capital Management LP | Reduced | 78.0K | 10.2K | -67.8K |
| Catalio Capital Management, LP | Sold Out | 67.3K | 0 | -67.3K |
| VANGUARD FIDUCIARY TRUST CO | Increased | 157.8K | 224.8K | +67.0K |
| SEI INVESTMENTS CO | New | 0 | 66.6K | +66.6K |
| RAYMOND JAMES FINANCIAL INC | Reduced | 247.1K | 180.9K | -66.2K |
| Affinity Asset Advisors, LLC | Reduced | 257.5K | 200.0K | -57.5K |
| CITIGROUP INC | Increased | 6.0K | 62.3K | +56.3K |
| Vestal Point Capital, LP | Sold Out | 54.0K | 0 | -54.0K |
| HighVista Strategies LLC | Increased | 131.3K | 184.8K | +53.5K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.