IONS Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. (IONS) Institutional Ownership
What the institutions did with IONS last quarter, from their 13F filings. Counting managers rather than shares is the point: a single index fund adding to a position tells you far less than four hundred separate managers all deciding to. Positions as reported for the quarter ended June 30, 2026.
Every manager below opens. Subscribers can see any firm's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
Sign in or subscribeOwnership map
Each block is one manager, sized by shares held and colored by how much they moved the position last quarter. Green added, red cut, grey stood pat.
Largest holders
| Manager | Shares | % of reported |
|---|---|---|
| FMR LLC | 24.6M | 13.7% |
| Capital World Investors | 21.7M | 12.1% |
| BlackRock, Inc. | 10.7M | 6.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7.9M | 4.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 7.7M | 4.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 7.2M | 4.0% |
| TWO SIGMA INVESTMENTS, LP | 6.3M | 3.5% |
| ROYAL BANK OF CANADA | 6.2M | 3.4% |
| STATE STREET CORP | 4.3M | 2.4% |
| T. Rowe Price Investment Management, Inc. | 4.0M | 2.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 3.6M | 2.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.2M | 1.8% |
| JPMORGAN CHASE & CO | 2.7M | 1.5% |
| Artisan Partners Limited Partnership | 2.6M | 1.5% |
| Tweedy, Browne Co LLC | 2.3M | 1.3% |
| Deep Track Capital, LP | 2.2M | 1.2% |
| GOLDMAN SACHS GROUP INC | 2.1M | 1.2% |
| BAKER BROS. ADVISORS LP | 2.0M | 1.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.0M | 1.1% |
| AMERICAN CENTURY COMPANIES INC | 1.9M | 1.1% |
| FRANKLIN RESOURCES INC | 1.6M | 0.9% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.6M | 0.9% |
| BARCLAYS PLC | 1.6M | 0.9% |
| Pictet Asset Management Holding SA | 1.6M | 0.9% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1.5M | 0.8% |
Largest changes
| Manager | Action | Previous | Current | Change |
|---|---|---|---|---|
| ROYAL BANK OF CANADA | Increased | 3.8M | 6.2M | +2.4M |
| T. Rowe Price Investment Management, Inc. | Reduced | 6.2M | 4.0M | -2.2M |
| BARCLAYS PLC | Increased | 289.9K | 1.6M | +1.3M |
| WELLINGTON MANAGEMENT GROUP LLP | Increased | 6.4M | 7.7M | +1.3M |
| Alyeska Investment Group, L.P. | Increased | 473.2K | 1.4M | +944.8K |
| Bellevue Group AG | Reduced | 1.8M | 972.3K | -846.4K |
| Capital International Investors | New | 0 | 823.8K | +823.8K |
| MILLENNIUM MANAGEMENT LLC | Reduced | 1.1M | 288.9K | -762.6K |
| CITADEL ADVISORS LLC | Reduced | 942.5K | 236.3K | -706.3K |
| Polar Capital Holdings Plc | Increased | 829.5K | 1.5M | +624.5K |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | Reduced | 1.4M | 787.3K | -616.8K |
| AMERIPRISE FINANCIAL INC | Reduced | 660.1K | 67.7K | -592.4K |
| Squarepoint Ops LLC | Reduced | 695.3K | 109.4K | -585.9K |
| Artisan Partners Limited Partnership | Increased | 2.1M | 2.6M | +581.7K |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | Increased | 785.3K | 1.3M | +515.1K |
| Capital World Investors | Increased | 21.2M | 21.7M | +482.9K |
| Davern Capital Partners, LP | Increased | 386.9K | 798.7K | +411.8K |
| GOLDMAN SACHS GROUP INC | Increased | 1.7M | 2.1M | +410.1K |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | 4.0M | 3.6M | -400.3K |
| TWO SIGMA INVESTMENTS, LP | Increased | 5.9M | 6.3M | +394.7K |
| Freestone Grove Partners LP | New | 0 | 340.0K | +340.0K |
| STATE STREET CORP | Increased | 4.0M | 4.3M | +339.3K |
| TimesSquare Capital Management, LLC | Increased | 275.7K | 614.1K | +338.4K |
| JANE STREET GROUP, LLC | Increased | 191.8K | 503.6K | +311.8K |
| JPMORGAN CHASE & CO | Increased | 2.4M | 2.7M | +308.2K |
| Qube Research & Technologies Ltd | Increased | 42.9K | 334.0K | +291.1K |
| NOMURA HOLDINGS INC | Increased | 114.1K | 402.2K | +288.1K |
| AMERICAN CENTURY COMPANIES INC | Increased | 1.7M | 1.9M | +283.3K |
| Carmignac Gestion | Increased | 53.0K | 321.0K | +268.0K |
| BlackRock, Inc. | Increased | 10.4M | 10.7M | +262.2K |
| MORGAN STANLEY | Increased | 1.0M | 1.3M | +254.9K |
| RENAISSANCE TECHNOLOGIES LLC | Increased | 305.5K | 559.4K | +253.9K |
| Deep Track Capital, LP | Increased | 2.0M | 2.2M | +250.0K |
| Zurich Insurance Group Ltd/FI | Sold Out | 239.6K | 0 | -239.6K |
| Life Cycle Investment Partners Ltd | New | 0 | 219.9K | +219.9K |
| J. Goldman & Co LP | Reduced | 235.3K | 40.4K | -194.9K |
| Eagle Health Investments LP | New | 0 | 194.6K | +194.6K |
| ExodusPoint Capital Management, LP | Reduced | 227.1K | 35.6K | -191.4K |
| NEUBERGER BERMAN GROUP LLC | Increased | 443.3K | 633.5K | +190.3K |
| Connor, Clark & Lunn Investment Management Ltd. | Reduced | 874.1K | 684.2K | -189.9K |
| TD Asset Management Inc | Reduced | 530.0K | 340.5K | -189.4K |
| CAPITAL FUND MANAGEMENT S.A. | Increased | 142.2K | 329.6K | +187.4K |
| UBS Group AG | Reduced | 808.4K | 624.9K | -183.6K |
| DIMENSIONAL FUND ADVISORS LP | Reduced | 267.2K | 84.7K | -182.5K |
| Trexquant Investment LP | Reduced | 213.6K | 31.5K | -182.1K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduced | 907.5K | 734.2K | -173.3K |
| Handelsbanken Fonder AB | Increased | 213.9K | 383.2K | +169.3K |
| Aberdeen Group plc | Increased | 113.8K | 277.4K | +163.6K |
| Pictet Asset Management Holding SA | Increased | 1.4M | 1.6M | +162.0K |
| PRICE T ROWE ASSOCIATES INC /MD/ | Increased | 3.0M | 3.2M | +159.2K |
| Invesco Ltd. | Reduced | 1.3M | 1.1M | -156.7K |
| Hudson Bay Capital Management LP | Reduced | 295.1K | 145.0K | -150.1K |
| NEW YORK STATE COMMON RETIREMENT FUND | Increased | 350.4K | 500.1K | +149.6K |
| D. E. Shaw & Co., Inc. | Reduced | 429.6K | 297.0K | -132.6K |
| Ikarian Capital, LLC | Sold Out | 127.0K | 0 | -127.0K |
| Integral Health Asset Management, LLC | Sold Out | 125.0K | 0 | -125.0K |
| Empowered Funds, LLC | Increased | 103.1K | 223.1K | +120.0K |
| Engineers Gate Manager LP | Reduced | 133.8K | 14.8K | -119.0K |
| Polymer Capital Management (HK) LTD | Increased | 61.2K | 177.9K | +116.7K |
| GROUPAMA ASSET MANAGMENT | Increased | 824.5K | 937.1K | +112.5K |
13F filings are due 45 days after quarter end and cover long positions in U.S.-listed equities only, so this is a lagged and partial picture: shorts, bonds and foreign listings never appear. Options positions are excluded here rather than folded into the share counts. Political ownership is coming.