IONS Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. (IONS) Hedge Fund Activity
This view isolates hedge funds from the broader institutional ownership shown on the Institutional tab. A pension fund tracking an index may have no view on a stock; when a hedge fund builds or exits a position, that decision can carry information. This page measures those changes. Positions as of June 30, 2026.
Based on quarterly 13F long-equity filings. Changes compare reported quarter-end positions; filings can be reported up to 45 days later and do not represent a fund's complete exposure.
Most significant moves
Ranked by conviction, not size — how much of the fund's own book the position represents, how far it moved, and what kind of fund made it.
| Fund | Action | Shares changed | Change | Est. value | Portfolio wt. | Score |
|---|---|---|---|---|---|---|
| Integral Health Asset Management Growth Healthcare | Sold Out | -125.0K | -100.0% | $9.9M | 0.0% | 60 |
| Farallon Capital Management Event Value | Sold Out | -4.8K | -100.0% | $380.6K | 0.0% | 60 |
| Alyeska Investment Group, L.P. | Increased | +944.8K | +199.7% | $74.9M | 0.3% | 58 |
| Tudor Investment Corporation Macro | Sold Out | -48.2K | -100.0% | $3.8M | 0.0% | 56 |
| Qube Research & Technologies Ltd Quant | Increased | +291.1K | +679.2% | $23.1M | 0.0% | 53 |
| RENAISSANCE TECHNOLOGIES LLC Quant | Increased | +253.9K | +83.1% | $20.1M | 0.1% | 52 |
| Readystate Asset Management Long/Short | Sold Out | -20.4K | -100.0% | $1.6M | 0.0% | 52 |
| CITADEL ADVISORS LLC Quant | Reduced | -706.3K | -74.9% | $56.0M | 0.0% | 52 |
| Winton Group Quant Macro | Sold Out | -106.5K | -100.0% | $8.4M | 0.0% | 52 |
| Capital Fund Management Quant Macro | Increased | +187.4K | +131.8% | $14.9M | 0.2% | 52 |
Most significant buyers
By move score, not size.
- Alyeska Investment Group, L.P.
- Qube Research & Technologies Ltd
- RENAISSANCE TECHNOLOGIES LLC
- Capital Fund Management
- ADAGE CAPITAL PARTNERS GP, L.L.C.
Most significant sellers
By move score, not size.
- Integral Health Asset Management
- Farallon Capital Management
- Tudor Investment Corporation
- Readystate Asset Management
- CITADEL ADVISORS LLC
Hedge fund positions
| Fund | Tier | Shares | Previous | Change | Change % | Portfolio wt. | Action | Score |
|---|---|---|---|---|---|---|---|---|
| Integral Health Asset Management | 2 | 0 | 125.0K | -125.0K | -100.0% | 0.0% | Sold Out | 60 |
| Farallon Capital Management | 1 | 0 | 4.8K | -4.8K | -100.0% | 0.0% | Sold Out | 60 |
| Alyeska Investment Group, L.P. | 2 | 1.4M | 473.2K | +944.8K | +199.7% | 0.3% | Increased | 58 |
| Tudor Investment Corporation | 2 | 0 | 48.2K | -48.2K | -100.0% | 0.0% | Sold Out | 56 |
| Qube Research & Technologies Ltd | 2 | 334.0K | 42.9K | +291.1K | +679.2% | 0.0% | Increased | 53 |
| RENAISSANCE TECHNOLOGIES LLC | 1 | 559.4K | 305.5K | +253.9K | +83.1% | 0.1% | Increased | 52 |
| Readystate Asset Management | 3 | 0 | 20.4K | -20.4K | -100.0% | 0.0% | Sold Out | 52 |
| CITADEL ADVISORS LLC | 1 | 236.3K | 942.5K | -706.3K | -74.9% | 0.0% | Reduced | 52 |
| Winton Group | 4 | 0 | 106.5K | -106.5K | -100.0% | 0.0% | Sold Out | 52 |
| Capital Fund Management | 3 | 329.6K | 142.2K | +187.4K | +131.8% | 0.2% | Increased | 52 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2 | 150.0K | 50.0K | +100.0K | +200.0% | 0.0% | Increased | 52 |
| Graham Capital Management | 3 | 16.7K | 0 | +16.7K | — | 0.1% | New | 51 |
| Deep Track Capital | 1 | 2.2M | 2.0M | +250.0K | +12.8% | 2.6% | Increased | 51 |
| Lighthouse Investment Partners | 3 | 0 | 5.0K | -5.0K | -100.0% | 0.0% | Sold Out | 51 |
| Y-Intercept | 4 | 67.4K | 0 | +67.4K | — | 0.1% | New | 51 |
| MILLENNIUM MANAGEMENT LLC | 2 | 288.9K | 1.1M | -762.6K | -72.5% | 0.0% | Reduced | 51 |
| MARSHALL WACE, LLP | 2 | 8.5K | 96.0K | -87.5K | -91.1% | 0.0% | Reduced | 50 |
| Squarepoint Ops LLC | 2 | 109.4K | 695.3K | -585.9K | -84.3% | 0.0% | Reduced | 49 |
| LMR Partners | 3 | 30.8K | 15.0K | +15.8K | +105.3% | 0.0% | Increased | 49 |
| J. Goldman & Co. | 3 | 40.4K | 235.3K | -194.9K | -82.8% | 0.1% | Reduced | 48 |
| Walleye Capital | 3 | 2 | 65.9K | -65.9K | -100.0% | 0.0% | Reduced | 47 |
| ExodusPoint Capital Management | 3 | 35.6K | 227.1K | -191.4K | -84.3% | 0.0% | Reduced | 47 |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 2 | 49.0K | 27.9K | +21.1K | +75.4% | 0.0% | Increased | 46 |
| Trexquant Investment | 3 | 31.5K | 213.6K | -182.1K | -85.2% | 0.0% | Reduced | 46 |
| Quantbot Technologies | 4 | 4.8K | 0 | +4.8K | — | 0.0% | New | 45 |
| Voleon Capital Management | 3 | 2.9K | 23.0K | -20.2K | -87.6% | 0.0% | Reduced | 44 |
| Caption Management | 3 | 1.8K | 15.6K | -13.8K | -88.7% | 0.0% | Reduced | 44 |
| Engineers Gate | 4 | 14.8K | 133.8K | -119.0K | -88.9% | 0.0% | Reduced | 42 |
| Boothbay Fund Management | 4 | 11.8K | 76.6K | -64.8K | -84.6% | 0.0% | Reduced | 41 |
| Hudson Bay Capital Management | 3 | 145.0K | 295.1K | -150.1K | -50.9% | 0.1% | Reduced | 40 |
| D. E. Shaw & Co., Inc. | 1 | 297.0K | 429.6K | -132.6K | -30.9% | 0.0% | Reduced | 39 |
| Aquatic Capital Management | 4 | 42.6K | 147.4K | -104.8K | -71.1% | 0.1% | Reduced | 38 |
| Perceptive Advisors | 1 | 566.0K | 504.0K | +62.0K | +12.3% | 0.7% | Increased | 38 |
| TWO SIGMA INVESTMENTS, LP | 2 | 6.3M | 5.9M | +394.7K | +6.7% | 0.4% | Increased | 33 |
| Man Group | 3 | 12.4K | 24.0K | -11.7K | -48.5% | 0.0% | Reduced | 33 |
| CenterBook Partners | 4 | 89.3K | 150.9K | -61.6K | -40.8% | 0.3% | Reduced | 33 |
| Braidwell | 2 | 116.8K | 130.9K | -14.1K | -10.8% | 0.4% | Reduced | 32 |
| Gotham Asset Management, LLC | 2 | 121.3K | 99.0K | +22.3K | +22.5% | 0.0% | Increased | 31 |
| Jain Global | 3 | 32.9K | 26.3K | +6.6K | +25.3% | 0.0% | Increased | 27 |
| ADAR1 Capital Management | 3 | 166.3K | 160.3K | +5.9K | +3.7% | 0.7% | Increased | 27 |
| Voloridge Investment Management | 2 | 655.5K | 672.9K | -17.4K | -2.6% | 0.2% | Reduced | 26 |
| AQR Capital Management | 3 | 22.1K | 28.8K | -6.7K | -23.4% | 0.0% | Reduced | 25 |
| Wolverine Asset Management | 2 | 22.3K | 22.8K | -475 | -2.1% | 0.1% | Reduced | 24 |
| Edgestream Partners | 4 | 56.7K | 68.4K | -11.7K | -17.0% | 0.1% | Reduced | 23 |
| Baker Bros. Advisors | 1 | 2.0M | 2.0M | 0 | +0.0% | 0.8% | Unchanged | 29 |
| Deerfield Management | 1 | 2.0M | 2.0M | 0 | +0.0% | 2.0% | Unchanged | 35 |
| Suvretta Capital Management | 2 | 10.8K | 10.8K | 0 | +0.0% | 0.0% | Unchanged | 21 |
Every fund above opens. Subscribers can see any manager's whole portfolio — every position, its weight, and what they bought, trimmed and exited last quarter.
Sign in or subscribeHedge funds are identified from their 13F filings, which are due 45 days after quarter end and cover long U.S.-listed equity positions only. A fund's short book never appears, so a reduced position can mean a changed view or a changed hedge — the filing doesn't say which.