KYMR Kymera Therapeutics, Inc.

NASDAQ
$113.15

Kymera Therapeutics, Inc. (KYMR) Insider Activity

What the officers, directors and large holders did with their own shares. Only open-market purchases and sales count toward the totals — grants, option exercises and shares withheld for tax are compensation mechanics, not decisions, and they're listed separately below.

30D 90D 6M 1Y
Insider signal In line Selling ran in line with KYMR's own trailing one-year pace, with 59% of sale value under a prearranged plan.
Cluster activity 0 buyers in the last 30 days 0 buyers in the last 90 days 6 sellers in the last 90 days
Insiders buying
1
2 transactions
Insiders selling
11
279 transactions
Purchases
$172.5M
2,005,813 shares
Sales
$481.3M
4,737,436 shares
Net activity
-$308.8M
purchases less sales

How much of that selling was preplanned? 59% planned / 41% discretionary

10b5-1 plan sales $281.8M 233 transactions · 2,825,064 shares
Discretionary sales $199.5M 46 transactions · 1,912,372 shares

Largest single sale: $89.2M.

Where they traded

Buy Sell Dot area is proportional to transaction value.

Last open-market purchase: December 11, 2025 .

Recent open-market activity

Date Insider Role Action Shares Price Value Held after
Adams Brian 3 fills Chief Legal Officer Sell 6,371 $116.83 $744.3K 55,416 −10.3% of holding
Mainolfi Nello Chief Executive Officer Sell 10b5-1 50,000 $119.00 $6.0M 666,568 −7% of holding
Mainolfi Nello 5 fills Chief Executive Officer Sell 10b5-1 80,000 $115.29 $9.2M 744,685 −9.7% of holding
Goodman Noah Chief Business Officer Sell 10b5-1 3,389 $114.29 $387.3K 47,179 −6.7% of holding
Jacobs Bruce N. 8 fills Chief Financial Officer Sell 10b5-1 77,109 $114.96 $8.9M 320,492 −19.4% of holding
Booth Bruce 28 fills Director Sell 10b5-1 153,300 $108.05 $16.6M 2,446,453 −5.9% of holding
4 fills Sell 1,630,658 $106.50 $173.7M 1,960,881 −45.4% of holding
Booth Bruce 24 fills Director Sell 10b5-1 467,878 $110.29 $51.6M 2,834,055 −14.2% of holding
Booth Bruce 46 fills Director Sell 10b5-1 548,321 $118.76 $65.1M 3,333,349 −14.1% of holding
Goodman Noah 2 fills Chief Business Officer Sell 10b5-1 5,000 $114.00 $570.0K 52,695 −8.7% of holding
Booth Bruce 4 fills Director Sell 10b5-1 134,720 $100.51 $13.5M 3,357,833 −3.9% of holding
Booth Bruce 2 fills Director Sell 10b5-1 1,408 $99.98 $140.8K 3,461,521 −0% of holding
Booth Bruce 24 fills Director Sell 10b5-1 278,128 $99.12 $27.6M 3,691,811 −7% of holding
Goodman Noah Chief Business Officer Sell 10b5-1 2,500 $99.00 $247.5K 50,195 −4.7% of holding
Booth Bruce 6 fills Director Sell 10b5-1 115,056 $91.01 $10.5M 3,744,763 −3% of holding
Booth Bruce 3 fills Director Sell 10b5-1 116,812 $90.34 $10.6M 3,807,660 −3% of holding
Chadwick Jeremy G 2 fills Chief Operating Officer Sell 10b5-1 4,279 $81.58 $349.1K 44,618 −8.8% of holding
Chadwick Jeremy G 3 fills Chief Operating Officer Sell 10b5-1 8,851 $79.80 $706.3K 53,348 −14.2% of holding
Chadwick Jeremy G 2 fills Chief Operating Officer Sell 4,054 $78.42 $317.9K 57,472 −6.6% of holding
Ridloff Elena Director Sell 10b5-1 3,000 $87.00 $261.0K None left
Mainolfi Nello 3 fills Chief Executive Officer Sell 10b5-1 30,000 $81.18 $2.4M 679,190 −4.2% of holding
Booth Bruce 3 fills Director Sell 10b5-1 6,000 $89.96 $539.8K 3,899,829 −0.2% of holding
Chadwick Jeremy G Chief Operating Officer Sell 10b5-1 300 $90.00 $27.0K 61,202 −0.5% of holding
Booth Bruce 3 fills Director Sell 10b5-1 5,335 $90.04 $480.4K 3,899,917 −0.1% of holding
Chadwick Jeremy G Chief Operating Officer Sell 10b5-1 1,300 $90.00 $117.0K 61,202 −2.1% of holding
Chadwick Jeremy G Chief Operating Officer Sell 10b5-1 5,251 $90.00 $472.6K 61,202 −7.9% of holding
Booth Bruce Director Sell 10b5-1 4,159 $89.97 $374.2K None left
Goodman Noah Chief Business Officer Sell 10b5-1 1,347 $90.00 $121.2K 50,195 −2.6% of holding
Goodman Noah Chief Business Officer Sell 10b5-1 2,000 $87.35 $174.7K 51,542 −3.7% of holding
Goodman Noah 2 fills Chief Business Officer Sell 5,764 $86.85 $500.6K 58,712 −8.9% of holding
Goodman Noah Chief Business Officer Sell 10b5-1 2,500 $89.00 $222.5K 53,542 −4.5% of holding
Chadwick Jeremy G 2 fills Chief Operating Officer Sell 10b5-1 14,640 $85.46 $1.3M 62,302 −19% of holding
Ridloff Elena 2 fills Director Sell 10b5-1 4,600 $85.42 $392.9K 1,200 −79.3% of holding
Chadwick Jeremy G Chief Operating Officer Sell 10b5-1 7,600 $85.38 $648.9K 61,202 −11% of holding
Ridloff Elena Director Sell 10b5-1 7,400 $85.37 $631.7K None left
Chadwick Jeremy G Chief Operating Officer Sell 10b5-1 24,727 $80.26 $2.0M 61,202 −28.8% of holding
Chadwick Jeremy G 5 fills Chief Operating Officer Sell 10b5-1 91,250 $77.41 $7.1M 129,696 −41.3% of holding
Esposito Pamela 3 fills Director Sell 10b5-1 2,500 $79.15 $197.9K 1,800 −58.1% of holding
Chadwick Jeremy G 3 fills Chief Operating Officer Sell 10b5-1 25,758 $83.30 $2.1M 92,045 −21.9% of holding
Jacobs Bruce N. 4 fills Chief Financial Officer Sell 4,895 $85.30 $417.5K 236,991 −2% of holding
Gollob Jared 4 fills Chief Medical Officer Sell 4,895 $85.30 $417.5K 121,537 −3.9% of holding
Chadwick Jeremy G 4 fills Chief Operating Officer Sell 3,919 $85.30 $334.3K 77,335 −4.8% of holding
Booth Bruce 2 fills Director Sell 10b5-1 81,866 $90.13 $7.4M 3,902,667 −2.1% of holding
Jacobs Bruce N. 3 fills Chief Financial Officer Sell 7,576 $88.93 $673.7K 243,020 −3% of holding
Gollob Jared 3 fills Chief Medical Officer Sell 5,613 $88.93 $499.1K 126,132 −4.3% of holding
Chadwick Jeremy G 3 fills Chief Operating Officer Sell 2,039 $88.93 $181.3K 79,219 −2.5% of holding
Mainolfi Nello 5 fills Chief Executive Officer Sell 10b5-1 30,000 $90.26 $2.7M 676,431 −4.2% of holding
Esposito Pamela 2 fills Director Sell 10b5-1 2,500 $87.31 $218.3K 600 −80.6% of holding
Esposito Pamela 3 fills Director Sell 10b5-1 5,500 $67.91 $373.5K 5,100 −51.9% of holding
Mainolfi Nello 2 fills Chief Executive Officer Sell 10b5-1 30,000 $78.06 $2.3M 669,091 −4.3% of holding
Esposito Pamela 4 fills Director Sell 10b5-1 27,563 $82.16 $2.3M 13,058 −67.9% of holding
Booth Bruce 2 fills Director Sell 678 $91.04 $61.7K 3,974,481 −0% of holding
2 fills Buy 2,005,813 $86.00 $172.5M 7,955,916
Booth Bruce 2 fills Director Sell 6,101 $91.23 $556.6K 3,975,051 −0.2% of holding
Booth Bruce 10 fills Director Sell 229,809 $91.73 $21.1M 4,141,757 −5.3% of holding
Mainolfi Nello Chief Executive Officer Sell 10b5-1 100,000 $89.17 $8.9M 660,482 −13.1% of holding
Gollob Jared 6 fills Chief Medical Officer Sell 10b5-1 49,307 $88.67 $4.4M 145,540 −25.3% of holding
Albers Jeffrey W. 2 fills Director Sell 10b5-1 5,000 $89.76 $448.8K 2,252 −68.9% of holding
Mainolfi Nello 3 fills Chief Executive Officer Sell 10b5-1 30,000 $60.99 $1.8M 688,620 −4.2% of holding
Gollob Jared 4 fills Chief Medical Officer Sell 10b5-1 59,576 $61.42 $3.7M 140,304 −29.8% of holding
Albers Jeffrey W. Director Sell 10b5-1 5,000 $59.19 $295.9K None left
Gollob Jared Chief Medical Officer Sell 10b5-1 3,114 $60.00 $186.8K 118,359 −2.6% of holding
Jacobs Bruce N. Chief Financial Officer Sell 10b5-1 79,220 $50.00 $4.0M 227,409 −25.8% of holding
Mainolfi Nello Chief Executive Officer Sell 10b5-1 30,000 $49.00 $1.5M 660,482 −4.3% of holding

Form 4s are due within two business days of a transaction, so this is close to real time — unlike the quarterly 13F data on the Institutional tab. A single large sale often reflects a prearranged 10b5-1 plan rather than a fresh view, so read a pattern of sales rather than any one of them.