IONS Ionis Pharmaceuticals, Inc.

NASDAQ
$51.44

Ionis Pharmaceuticals, Inc. (IONS) Insider Activity

What the officers, directors and large holders did with their own shares. Only open-market purchases and sales count toward the totals — grants, option exercises and shares withheld for tax are compensation mechanics, not decisions, and they're listed separately below.

30D 90D 6M 1Y
Insider signal In line Selling ran in line with IONS's own trailing one-year pace, with 81% of sale value under a prearranged plan.
Cluster activity 0 buyers in the last 30 days 1 buyer in the last 90 days 9 sellers in the last 90 days
Insiders buying
1
2 transactions
Insiders selling
19
145 transactions
Purchases
$1.1M
20,000 shares
Sales
$155.3M
2,050,250 shares
Net activity
-$154.2M
purchases less sales

How much of that selling was preplanned? 81% planned / 19% discretionary

10b5-1 plan sales $125.8M 112 transactions · 1,675,604 shares
Discretionary sales $29.5M 33 transactions · 374,646 shares

Largest single sale: $14.9M.

Where they traded

Buy Sell Dot area is proportional to transaction value.

Last open-market purchase: July 31, 2026 , by Hayden Michael R .

Recent open-market activity

Date Insider Role Action Shares Price Value Held after
Hayden Michael R Director Buy 5,000 $51.60 $258.0K 24,000
Hayden Michael R Director Buy 15,000 $53.38 $800.7K 19,000
BENNETT C FRANK 2 fills EVP, Chief Scientific Officer Sell 10b5-1 20,536 $84.95 $1.7M 75,018 −21.5% of holding
Diaz Allene M. Director Sell 10b5-1 10,111 $85.42 $863.6K 3,811 −72.6% of holding
Kordasiewicz Holly B. EVP, Chief Development Officer Sell 10b5-1 362 $84.30 $30.5K 22,096 −1.6% of holding
KLEIN JOSEPH III 2 fills Director Sell 10b5-1 11,518 $79.04 $910.4K 22,433 −33.9% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 50,000 $80.59 $4.0M 245,571 −16.9% of holding
Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 10b5-1 26,000 $81.05 $2.1M 77,114 −25.2% of holding
Baroldi Joseph EVP, Chief Business Officer Sell 10b5-1 5,635 $80.16 $451.7K 4,669 −54.7% of holding
O'NEIL PATRICK R. EVP CLO & General Counsel Sell 10b5-1 3,069 $80.00 $245.5K 61,470 −4.8% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 21,072 $78.49 $1.7M 245,571 −7.9% of holding
Swayze Eric EVP Research Sell 10b5-1 10,602 $79.18 $839.5K 21,759 −32.8% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 14,565 $78.41 $1.1M 245,571 −5.6% of holding
BERTHELSEN SPENCER R Director Sell 10b5-1 8,000 $73.49 $587.9K 156,013 −4.9% of holding
Kordasiewicz Holly B. 2 fills EVP, Chief Development Officer Sell 10b5-1 60,846 $73.41 $4.5M 42,300 −59% of holding
BERTHELSEN SPENCER R Director Sell 10b5-1 8,000 $75.67 $605.4K 156,013 −4.9% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 3,220 $78.68 $253.3K 242,662 −1.3% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 1,316 $78.01 $102.7K 242,662 −0.5% of holding
LOSCALZO JOSEPH 2 fills Director Sell 10b5-1 77,289 $75.06 $5.8M 54,111 −58.8% of holding
KLEIN JOSEPH III 2 fills Director Sell 10b5-1 10,111 $73.51 $743.2K 12,445 −44.8% of holding
Baroldi Joseph EVP, Chief Business Officer Sell 10b5-1 1,626 $71.79 $116.7K 44,909 −3.5% of holding
Baroldi Joseph EVP, Chief Business Officer Sell 5,619 $74.56 $419.0K 46,535 −10.8% of holding
Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sell 4,902 $75.17 $368.5K 23,713 −17.1% of holding
Birchler Brian EVP, Corp and Development Ops Sell 973 $75.04 $73.0K 67,500 −1.4% of holding
PARSHALL B LYNNE 2 fills Director Sell 10b5-1 5,000 $76.27 $381.4K 51,878 −8.8% of holding
Devers Shannon L. EVP, Chief Human Resources Ofc Sell 10b5-1 6,193 $74.05 $458.6K 16,348 −27.5% of holding
KLEIN JOSEPH III 2 fills Director Sell 10b5-1 22,321 $75.55 $1.7M 13,230 −62.8% of holding
Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 10b5-1 5,812 $70.97 $412.5K 63,890 −8.3% of holding
HOUGEN ELIZABETH L EVP, Finance & CFO Sell 10b5-1 10,172 $73.21 $744.7K 82,660 −11% of holding
HOUGEN ELIZABETH L 2 fills EVP, Finance & CFO Sell 10b5-1 215,048 $72.40 $15.6M 102,272 −67.8% of holding
Jenne Kyle 2 fills EVP, Chf GL Pdt Str Ofcr Sell 10b5-1 37,277 $75.85 $2.8M 27,800 −57.3% of holding
Monia Brett P 2 fills Chief Executive Officer Sell 10b5-1 34,103 $75.92 $2.6M 260,253 −11.6% of holding
Monia Brett P 3 fills Chief Executive Officer Sell 10b5-1 126,670 $75.20 $9.5M 361,950 −25.9% of holding
O'NEIL PATRICK R. EVP CLO & General Counsel Sell 10b5-1 10,148 $75.25 $763.7K 62,211 −14% of holding
Baroldi Joseph 2 fills EVP, Chief Business Officer Sell 10b5-1 439 $80.00 $35.1K 4,347 −9.2% of holding
LOSCALZO JOSEPH Director Sell 10b5-1 200 $80.00 $16.0K 36,330 −0.5% of holding
BENNETT C FRANK 3 fills EVP, Chief Scientific Officer Sell 10b5-1 85,089 $79.23 $6.7M 94,043 −47.5% of holding
Diaz Allene M. 3 fills Director Sell 10b5-1 54,878 $79.35 $4.4M 19,424 −73.9% of holding
KLEIN JOSEPH III 3 fills Director Sell 10b5-1 21,332 $79.51 $1.7M 18,820 −53.1% of holding
Devers Shannon L. 3 fills EVP, Chief Human Resources Ofc Sell 10b5-1 20,106 $79.40 $1.6M 28,326 −41.5% of holding
Baroldi Joseph 3 fills EVP, Chief Business Officer Sell 10b5-1 6,220 $79.72 $495.9K 41,317 −13.1% of holding
LOSCALZO JOSEPH Director Sell 10b5-1 832 $80.33 $66.8K 36,330 −2.2% of holding
Swayze Eric 2 fills EVP Research Sell 10b5-1 15,642 $81.76 $1.3M 38,312 −29% of holding
PARSHALL B LYNNE Director Sell 10b5-1 5,000 $82.72 $413.6K 56,344 −8.2% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 29,430 $85.79 $2.5M 254,497 −10.4% of holding
BENNETT C FRANK 3 fills EVP, Chief Scientific Officer Sell 85,089 $82.93 $7.1M 80,293 −51.4% of holding
Monia Brett P Chief Executive Officer Sell 62,970 $82.72 $5.2M 283,927 −18.2% of holding
HOUGEN ELIZABETH L EVP, Finance & CFO Sell 6,988 $83.24 $581.7K 132,881 −5% of holding
O'NEIL PATRICK R. EVP CLO & General Counsel Sell 6,179 $83.53 $516.2K 71,983 −7.9% of holding
Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 6,179 $83.45 $515.6K 69,702 −8.1% of holding
Birchler Brian EVP, Corp and Development Ops Sell 6,179 $83.03 $513.0K 66,247 −8.5% of holding
Swayze Eric EVP Research Sell 6,179 $82.93 $512.4K 47,747 −11.5% of holding
BENNETT C FRANK EVP, Chief Scientific Officer Sell 5,885 $82.95 $488.1K 100,293 −5.5% of holding
Baroldi Joseph EVP, Chief Business Officer Sell 5,296 $82.96 $439.4K 45,413 −10.4% of holding
Devers Shannon L. EVP, Chief Human Resources Ofc Sell 10b5-1 3,977 $81.34 $323.5K 22,541 −15% of holding
Monia Brett P Chief Executive Officer Sell 44,034 $74.82 $3.3M 224,683 −16.4% of holding
HOUGEN ELIZABETH L EVP, Finance & CFO Sell 12,922 $75.22 $972.0K 126,307 −9.3% of holding
Swayze Eric 2 fills EVP Research Sell 9,933 $75.34 $748.4K 41,935 −19.2% of holding
Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 9,302 $75.59 $703.1K 63,890 −12.7% of holding
O'NEIL PATRICK R. EVP CLO & General Counsel Sell 9,191 $75.84 $697.0K 66,171 −12.2% of holding
BENNETT C FRANK EVP, Chief Scientific Officer Sell 8,977 $75.15 $674.6K 94,757 −8.7% of holding
Birchler Brian EVP, Corp and Development Ops Sell 8,480 $75.11 $636.9K 60,435 −12.3% of holding
Devers Shannon L. EVP, Chief Human Resources Ofc Sell 8,353 $75.95 $634.4K 26,518 −24% of holding
Baroldi Joseph 2 fills EVP, Chief Business Officer Sell 8,056 $75.75 $610.3K 40,431 −16.6% of holding
Kordasiewicz Holly B. EVP, Chief Development Officer Sell 4,141 $75.66 $313.3K 14,718 −22% of holding
Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sell 1,823 $75.96 $138.5K 16,389 −10% of holding
Devers Shannon L. 5 fills EVP, Chief Human Resources Ofc Sell 10b5-1 44,199 $85.08 $3.8M 17,494 −71.6% of holding
Swayze Eric 2 fills EVP Research Sell 10b5-1 23,463 $79.12 $1.9M 30,453 −43.5% of holding
WENDER JOSEPH H 2 fills Director Sell 10b5-1 28,000 $80.82 $2.3M 43,464 −39.2% of holding
Devers Shannon L. EVP, Chief Human Resources Ofc Sell 10b5-1 16,777 $80.91 $1.4M 17,494 −49% of holding
KLEIN JOSEPH III 3 fills Director Sell 10b5-1 12,000 $80.00 $960.0K None left
HERMAN JOAN E 2 fills Director Sell 44,000 $72.13 $3.2M 46,086 −48.8% of holding
Geary Richard S 2 fills EVP, Chief Development Officer Sell 10b5-1 33,038 $75.72 $2.5M 59,657 −35.6% of holding
Birchler Brian EVP, Corp and Development Ops Sell 10b5-1 8,000 $76.17 $609.4K 48,826 −14.1% of holding
Geary Richard S 2 fills EVP, Chief Development Officer Sell 10b5-1 1,601 $75.01 $120.1K 59,657 −2.6% of holding
Geary Richard S 2 fills EVP, Chief Development Officer Sell 1,680 $75.05 $126.1K 59,657 −2.7% of holding
Geary Richard S 2 fills EVP, Chief Development Officer Sell 10b5-1 1,680 $75.05 $126.1K 59,657 −2.7% of holding
Geary Richard S 3 fills EVP, Chief Development Officer Sell 10b5-1 89,249 $75.11 $6.7M 79,657 −52.8% of holding
LOSCALZO JOSEPH Director Sell 10b5-1 16,000 $75.10 $1.2M 36,330 −30.6% of holding
WENDER JOSEPH H Director Sell 10b5-1 11,200 $75.16 $841.8K 64,035 −14.9% of holding
WENDER JOSEPH H 3 fills Director Sell 10b5-1 16,800 $73.26 $1.2M 89,551 −15.8% of holding
Devers Shannon L. EVP, Chief Human Resources Ofc Sell 1,263 $73.62 $93.0K 17,494 −6.7% of holding
Swayze Eric EVP Research Sell 53 $73.62 $3.9K 256 −17.2% of holding
Birchler Brian EVP, Corp and Development Ops Sell 10b5-1 12,425 $72.23 $897.4K 56,826 −17.9% of holding
Devers Shannon L. EVP, Chief Human Resources Ofc Sell 10b5-1 6,000 $72.94 $437.7K 15,937 −27.4% of holding
PARSHALL B LYNNE Director Sell 10b5-1 5,000 $71.74 $358.7K 61,344 −7.5% of holding
Birchler Brian EVP, Corp and Development Ops Sell 10b5-1 11,475 $72.03 $826.6K 56,826 −16.8% of holding
O'NEIL PATRICK R. 2 fills EVP CLO & General Counsel Sell 10b5-1 13,441 $69.74 $937.3K 57,130 −19% of holding
Swayze Eric EVP Research Sell 10b5-1 6,849 $69.02 $472.7K 30,453 −18.4% of holding
Baroldi Joseph EVP, Chief Business Officer Sell 10b5-1 1,625 $69.37 $112.7K 30,301 −5.1% of holding
Monia Brett P Chief Executive Officer Sell 10b5-1 437 $69.26 $30.3K 179,572 −0.2% of holding
O'NEIL PATRICK R. 2 fills EVP CLO & General Counsel Sell 10b5-1 64,664 $67.69 $4.4M 57,130 −53.1% of holding
Baroldi Joseph EVP, Chief Business Officer Sell 10b5-1 15,000 $68.01 $1.0M 31,926 −32% of holding
Swayze Eric EVP Research Sell 10b5-1 12,972 $66.23 $859.1K 37,302 −25.8% of holding
WENDER JOSEPH H Director Sell 10b5-1 16,800 $65.50 $1.1M 92,035 −15.4% of holding
Swayze Eric EVP Research Sell 10b5-1 14,142 $66.09 $934.7K 37,302 −27.5% of holding
Geary Richard S EVP, Chief Development Officer Sell 10b5-1 57,900 $65.24 $3.8M 79,657 −42.1% of holding
HOUGEN ELIZABETH L EVP, Finance & CFO Sell 10b5-1 49,800 $65.26 $3.2M 110,500 −31.1% of holding
O'NEIL PATRICK R. EVP CLO & General Counsel Sell 10b5-1 14,827 $64.68 $959.0K 57,130 −20.6% of holding
O'NEIL PATRICK R. EVP CLO & General Counsel Sell 10b5-1 10,473 $64.54 $675.9K 57,130 −15.5% of holding

Form 4s are due within two business days of a transaction, so this is close to real time — unlike the quarterly 13F data on the Institutional tab. A single large sale often reflects a prearranged 10b5-1 plan rather than a fresh view, so read a pattern of sales rather than any one of them.