AMLX Amylyx Pharmaceuticals, Inc.

NASDAQ
$27.62

Amylyx Pharmaceuticals, Inc. (AMLX) Insider Activity

What the officers, directors and large holders did with their own shares. Only open-market purchases and sales count toward the totals — grants, option exercises and shares withheld for tax are compensation mechanics, not decisions, and they're listed separately below.

30D 90D 6M 1Y
Insider signal In line Selling ran in line with AMLX's own trailing one-year pace, with 32% of sale value under a prearranged plan.
Cluster activity 0 buyers in the last 30 days 0 buyers in the last 90 days 6 sellers in the last 90 days
Insiders buying
1
1 transaction
Insiders selling
6
13 transactions
Purchases
$51.3K
3,800 shares
Sales
$4.3M
151,302 shares
Net activity
-$4.3M
purchases less sales

How much of that selling was preplanned? 32% planned / 68% discretionary

10b5-1 plan sales $1.4M 3 transactions · 60,000 shares
Discretionary sales $2.9M 10 transactions · 91,302 shares

Largest single sale: $950.0K.

Where they traded

Buy Sell Dot area is proportional to transaction value.

Last open-market purchase: May 21, 2026 , by Firestone Karen .

Recent open-market activity

Date Insider Role Action Shares Price Value Held after
MILNE GEORGE M JR Director Sell 10b5-1 30,000 $27.70 $830.9K 782,881 −3.7% of holding
Cohen Joshua B 2 fills Co-Chief Executive Officer Sell 30,464 $32.19 $980.5K 3,614,042 −0.8% of holding
Klee Justin B. 2 fills Co-Chief Executive Officer Sell 30,464 $32.18 $980.3K 3,614,495 −0.8% of holding
FRATES JAMES M 2 fills Chief Financial Officer Sell 10,810 $32.36 $349.8K 234,667 −4.4% of holding
Bedrosian Camille L 2 fills Chief Medical Officer Sell 10,028 $32.40 $324.9K 280,145 −3.5% of holding
Mazzariello Gina 2 fills Chief Legal Officer Sell 9,536 $32.46 $309.5K 190,849 −4.8% of holding
Mazzariello Gina Chief Legal Officer Sell 10b5-1 15,000 $17.61 $264.1K 179,090 −7.7% of holding
Mazzariello Gina Chief Legal Officer Sell 10b5-1 15,000 $18.32 $274.7K 194,090 −7.2% of holding
Firestone Karen Director Buy 3,800 $13.51 $51.3K 66,900

Form 4s are due within two business days of a transaction, so this is close to real time — unlike the quarterly 13F data on the Institutional tab. A single large sale often reflects a prearranged 10b5-1 plan rather than a fresh view, so read a pattern of sales rather than any one of them.