AMLX Amylyx Pharmaceuticals, Inc.

NASDAQ
$33.64

Amylyx Pharmaceuticals, Inc. (AMLX) Insider Activity

What the officers, directors and large holders did with their own shares. Only open-market purchases and sales count toward the totals — grants, option exercises and shares withheld for tax are compensation mechanics, not decisions, and they're listed separately below.

30D 90D 6M 1Y
Insider signal In line Selling ran in line with AMLX's own trailing one-year pace, with 5% of sale value under a prearranged plan.
Cluster activity 0 buyers in the last 30 days 0 buyers in the last 90 days 5 sellers in the last 90 days
Insiders buying
1
2 transactions
Insiders selling
5
37 transactions
Purchases
$152.2K
11,900 shares
Sales
$10.6M
635,528 shares
Net activity
-$10.5M
purchases less sales

How much of that selling was preplanned? 5% planned / 95% discretionary

10b5-1 plan sales $538.9K 2 transactions · 30,000 shares
Discretionary sales $10.1M 35 transactions · 605,528 shares

Largest single sale: $1.9M.

Where they traded

Buy Sell Dot area is proportional to transaction value.

Last open-market purchase: May 21, 2026 , by Firestone Karen .

Recent open-market activity

Date Insider Role Action Shares Price Value Held after
Cohen Joshua B 2 fills Co-Chief Executive Officer Sell 30,464 $32.19 $980.5K 3,614,042 −0.8% of holding
Klee Justin B. 2 fills Co-Chief Executive Officer Sell 30,464 $32.18 $980.3K 3,614,495 −0.8% of holding
FRATES JAMES M 2 fills Chief Financial Officer Sell 10,810 $32.36 $349.8K 234,667 −4.4% of holding
Bedrosian Camille L 2 fills Chief Medical Officer Sell 10,028 $32.40 $324.9K 280,145 −3.5% of holding
Mazzariello Gina 2 fills Chief Legal Officer Sell 9,536 $32.46 $309.5K 190,849 −4.8% of holding
Mazzariello Gina Chief Legal Officer Sell 10b5-1 15,000 $17.61 $264.1K 179,090 −7.7% of holding
Mazzariello Gina Chief Legal Officer Sell 10b5-1 15,000 $18.32 $274.7K 194,090 −7.2% of holding
Firestone Karen Director Buy 3,800 $13.51 $51.3K 66,900
Cohen Joshua B Co-Chief Executive Officer Sell 29,282 $14.48 $424.1K 3,334,683 −0.9% of holding
Klee Justin B. Co-Chief Executive Officer Sell 29,282 $14.47 $423.8K 3,334,616 −0.9% of holding
FRATES JAMES M Chief Financial Officer Sell 7,909 $14.52 $114.9K 165,638 −4.6% of holding
Mazzariello Gina Chief Legal Officer Sell 6,844 $14.52 $99.4K 134,430 −4.8% of holding
Bedrosian Camille L Chief Medical Officer Sell 6,461 $14.58 $94.2K 169,295 −3.7% of holding
Mazzariello Gina Chief Legal Officer Sell 3,419 $14.14 $48.4K 141,274 −2.4% of holding
Klee Justin B. Co-Chief Executive Officer Sell 15,500 $14.69 $227.6K 3,363,898 −0.5% of holding
Cohen Joshua B Co-Chief Executive Officer Sell 15,500 $14.68 $227.6K 3,363,965 −0.5% of holding
FRATES JAMES M Chief Financial Officer Sell 3,557 $14.65 $52.1K 173,547 −2% of holding
Mazzariello Gina Chief Legal Officer Sell 3,448 $14.65 $50.5K 144,693 −2.3% of holding
Klee Justin B. Co-Chief Executive Officer Sell 1,995 $13.89 $27.7K 3,379,398 −0.1% of holding
Cohen Joshua B Co-Chief Executive Officer Sell 1,974 $13.83 $27.3K 3,379,465 −0.1% of holding
Cohen Joshua B Co-Chief Executive Officer Sell 136,193 $13.59 $1.9M 3,378,621 −3.9% of holding
Klee Justin B. Co-Chief Executive Officer Sell 136,193 $13.58 $1.8M 3,378,546 −3.9% of holding
Cohen Joshua B Co-Chief Executive Officer Sell 7,715 $11.09 $85.6K 3,317,632 −0.2% of holding
Klee Justin B. Co-Chief Executive Officer Sell 7,715 $11.09 $85.6K 3,317,586 −0.2% of holding
FRATES JAMES M Chief Financial Officer Sell 3,326 $11.11 $37.0K 177,104 −1.8% of holding
Firestone Karen Director Buy 8,100 $12.45 $100.8K 63,100
Bedrosian Camille L Chief Medical Officer Sell 6,580 $14.35 $94.4K 175,756 −3.6% of holding
Klee Justin B. 2 fills Co-Chief Executive Officer Sell 29,975 $14.38 $431.0K 3,325,501 −0.9% of holding
Cohen Joshua B 2 fills Co-Chief Executive Officer Sell 29,933 $14.35 $429.5K 3,325,547 −0.9% of holding
Bedrosian Camille L Chief Medical Officer Sell 12,039 $14.58 $175.5K 182,336 −6.2% of holding
FRATES JAMES M Chief Financial Officer Sell 10,558 $14.65 $154.7K 280,430 −3.6% of holding
Mazzariello Gina Chief Legal Officer Sell 8,828 $14.58 $128.7K 148,141 −5.6% of holding

Form 4s are due within two business days of a transaction, so this is close to real time — unlike the quarterly 13F data on the Institutional tab. A single large sale often reflects a prearranged 10b5-1 plan rather than a fresh view, so read a pattern of sales rather than any one of them.